PDB
7W0O
Resolution
3.8 Å
Released
July 27, 2022
Receptor
apelin
Class
A
Species
Homo sapiens
Ligand
Elabela/Toddler-32 (Human)
Function
Agonist
Reference
10.1038/S41594-022-00797-5

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Ligand Amino Acid Generic Number Segment Interaction Type
Elabela/Toddler-32 (Human) W85 2.60x60 TM2 aromatic (face-to-edge)
Elabela/Toddler-32 (Human) I109 3.32x32 TM3 hydrophobic
Elabela/Toddler-32 (Human) R168 ECL2 polar (charge-assisted hydrogen bond)
Elabela/Toddler-32 (Human) Q180 ECL2 Van der Waals
Elabela/Toddler-32 (Human) C181 45.50x50 ECL2 Van der Waals
Elabela/Toddler-32 (Human) C181 45.50x50 ECL2 polar (hydrogen bond with backbone)
Elabela/Toddler-32 (Human) Y182 45.51x51 ECL2 hydrophobic
Elabela/Toddler-32 (Human) Y182 45.51x51 ECL2 Van der Waals
Elabela/Toddler-32 (Human) M183 45.52x52 ECL2 polar (hydrogen bond with backbone)
Elabela/Toddler-32 (Human) M183 45.52x52 ECL2 Van der Waals
Elabela/Toddler-32 (Human) Y264 6.51x51 TM6 polar (hydrogen bond)
Elabela/Toddler-32 (Human) Y264 6.51x51 TM6 polar (hydrogen bond)
Elabela/Toddler-32 (Human) M288 7.32x31 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
Helix box plot — Download: PNG | SVG G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7

GPCRdb(A)
GPCRdb(A)
apelin receptor
TM2
2x60 2.60x60 W85
TM3
3x32 3.32x32 I109
ECL2
45x50 45.50x50 C181
45x51 45.51x51 Y182
45x52 45.52x52 M183
TM6
6x51 6.51x51 Y264
TM7
7x31 7.32x31 M288