S1P3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7EW2

RESOLUTION

3.1 Å

REFERENCE

10.1038/S41422-021-00567-W

PUBLICATION DATE

Sept. 29, 2021

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

(S)-FTY720-phosphate - Agonist pubchem gtoplig chembl_ligand

ENDOGENOUS LIGANDS

sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate, sphingosine 1-phosphate



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 145 - G.S1 E 33 G.S1.01
Polar ICL2 Y 146 - G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 P 145 - G.H5 I 343 G.H5.15
Hydrophobic TM3 M 140 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 M 140 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 A 240 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 240 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 136 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 M 140 3x54 G.H5 C 351 G.H5.23
Polar TM2 N 72 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 72 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 145 - G.S1 V 34 G.S1.02
Polar TM6 N 231 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 N 231 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 N 231 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 R 144 - G.hns1 R 32 G.hns1.03
Polar ICL2 K 142 - G.H5 N 347 G.H5.19
Hydrophobic TM5 I 218 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 218 5x61 G.H5 L 353 G.H5.25
Polar H8 S 302 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 302 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 302 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 V 222 5x65 G.H5 I 344 G.H5.16
Ionic TM6 R 237 6x29 G.H5 D 341 G.H5.13
Polar TM6 R 237 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 237 6x29 G.H5 D 341 G.H5.13
Hydrophobic ICL2 M 143 - G.H5 T 340 G.H5.12
Polar TM3 R 136 3x50 G.H5 G 352 G.H5.24
Polar TM6 N 233 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 T 244 6x36 G.H5 L 353 G.H5.25
Polar ICL2 Y 146 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 Y 146 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 Y 146 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 Y 146 - G.S1 K 35 G.S1.03
Hydrophobic ICL3 V 229 - G.H5 D 337 G.H5.09
Hydrophobic ICL2 M 143 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 M 143 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 M 143 - G.H5 I 344 G.H5.16
Hydrophobic TM6 N 233 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 V 222 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 222 5x65 G.H5 L 348 G.H5.20
Polar TM6 N 234 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 N 234 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 N 234 6x26 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 145 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 T 139 3x53 G.H5 C 351 G.H5.23
Polar TM6 N 234 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 N 234 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 N 234 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 237 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 237 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM5 K 228 5x71 G.H5 D 337 G.H5.09
Polar ICL2 Y 146 - G.h2s4 G 217 G.h2s4.03
Van-der-waals ICL2 Y 146 - G.h2s4 G 217 G.h2s4.03
Hydrophobic TM5 I 218 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM5 S 225 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 S 225 5x68 G.H5 I 344 G.H5.16
Van-der-waals ICL2 D 147 - G.H5 D 350 G.H5.22
Hydrophobic TM6 L 241 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM2 M 74 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 M 74 2x39 G.H5 C 351 G.H5.23
Polar TM6 N 233 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 N 233 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 L 241 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 241 6x33 G.H5 L 353 G.H5.25
Ionic TM6 R 237 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 237 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM3 R 136 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 D 147 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL3 V 229 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 V 229 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 Y 146 - G.S1 E 33 G.S1.01
Van-der-waals ICL2 Y 146 - G.S1 E 33 G.S1.01
Hydrophobic TM6 R 237 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM3 M 140 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 M 140 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 M 140 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL3 V 229 - G.S6 Y 320 G.S6.02