GLP-1 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Oryctolagus cuniculus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

5VAI

RESOLUTION

4.1 Å

REFERENCE

10.1038/NATURE22394

PUBLICATION DATE

May 24, 2017

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

90 interactions (Click to see)

LIGANDS

CHEMBL410972 - Agonist chembl_ligand pubchem pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 359 6x48 G.H5 Y 391 G.H5.23
Van-der-waals TM6 L 359 6x48 G.H5 Y 391 G.H5.23
Polar TM3 A 256 3x59 G.H5 R 380 G.H5.12
Hydrophobic TM3 A 256 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 A 256 3x59 G.H5 R 380 G.H5.12
Hydrophobic TM6 T 353 6x42 G.H5 L 393 G.H5.25
Polar TM4 Q 263 4x40 G.HN Q 31 G.HN.48
Hydrophobic TM4 Q 263 4x40 G.HN Q 31 G.HN.48
Van-der-waals TM4 Q 263 4x40 G.HN Q 31 G.HN.48
Hydrophobic ICL3 L 339 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 L 339 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM7 L 401 7x56 G.H5 E 392 G.H5.24
Polar TM6 S 352 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 352 6x41 G.H5 L 393 G.H5.25
Polar H8 N 406 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 N 406 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 406 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM6 L 356 6x45 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 176 2x46 G.H5 Y 391 G.H5.23
Polar ICL3 K 342 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 K 342 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM3 L 251 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 251 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM7 V 405 7x60 G.H5 E 392 G.H5.24
Hydrophobic ICL3 N 338 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 N 338 - G.S6 Y 360 G.S6.02
Hydrophobic TM5 V 331 5x61 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 331 5x61 G.H5 L 388 G.H5.20
Polar TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM4 E 262 4x39 G.HN Q 35 G.HN.52
Van-der-waals TM4 Q 263 4x40 G.HN Q 35 G.HN.52
Polar TM6 S 352 6x41 G.H5 E 392 G.H5.24
Hydrophobic TM6 L 356 6x45 G.H5 L 393 G.H5.25
Polar TM5 K 334 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 334 5x64 G.H5 R 385 G.H5.17
Polar H8 E 408 8x49 G.H5 Q 390 G.H5.22
Hydrophobic H8 E 408 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 E 408 8x49 G.H5 Q 390 G.H5.22
Polar TM2 R 176 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 176 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 176 2x46 G.H5 Q 390 G.H5.22
Polar TM4 S 261 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM4 S 261 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 S 261 4x38 G.HN Q 35 G.HN.52
Polar TM2 H 180 2x50 G.H5 Y 391 G.H5.23
Hydrophobic TM2 H 180 2x50 G.H5 Y 391 G.H5.23
Van-der-waals TM2 H 180 2x50 G.H5 Y 391 G.H5.23
Ionic TM5 K 334 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 334 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 334 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 334 5x64 G.H5 D 381 G.H5.13
Hydrophobic ICL3 L 339 - G.H5 L 394 G.H5.26
Hydrophobic TM7 Y 402 7x57 G.H5 E 392 G.H5.24
Van-der-waals TM7 Y 402 7x57 G.H5 E 392 G.H5.24
Polar H8 N 407 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 254 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 254 3x57 G.H5 H 387 G.H5.19