Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

5VAI

SPECIES

Oryctolagus cuniculus

RESOLUTION

4.100

PREFERRED CHAIN

R

PUBLICATION DATE

May 24, 2017

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL410972 L32 N-term polar (hydrogen bond with backbone)
CHEMBL410972 W39 N-term aromatic (face-to-edge)
CHEMBL410972 Y69 N-term hydrophobic
CHEMBL410972 W91 N-term hydrophobic
CHEMBL410972 E128 N-term polar (charge-charge)
CHEMBL410972 E138 1.33x33 TM1 polar (charge-assisted hydrogen bond)
CHEMBL410972 L142 1.37x37 TM1 hydrophobic
CHEMBL410972 K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
CHEMBL410972 L201 2.71x71 TM2 hydrophobic
CHEMBL410972 M204 2.74x74 TM2 polar (charge-assisted hydrogen bond)
CHEMBL410972 H212 ECL1 aromatic (edge-to-face)
CHEMBL410972 M233 3.36x36 TM3 hydrophobic
CHEMBL410972 W297 45.51x51 ECL2 polar (hydrogen bond with backbone)
CHEMBL410972 T298 45.52x52 ECL2 polar (hydrogen bond)
CHEMBL410972 T298 45.52x52 ECL2 polar (hydrogen bond)
CHEMBL410972 R299 ECL2 polar (charge-assisted hydrogen bond)
CHEMBL410972 R299 ECL2 polar (hydrogen bond with backbone)
CHEMBL410972 R299 ECL2 polar (charge-assisted hydrogen bond)
CHEMBL410972 W306 5.36x37 TM5 polar (hydrogen bond)
CHEMBL410972 F385 7.40x39 TM7 hydrophobic
CHEMBL410972 L388 7.43x42 TM7 hydrophobic

Ligands

CHEMBL410972

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L S L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F K L Y L S G I W G V P L L F V I P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F 6 I A V M L G Q F S T F S L E T F L K V 7
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ICL1 R H L H ICL1ECL1 H Q W D G L L S Y Q D S ECL1ICL2 A V F ICL2ECL2 D E G C W T R N S ECL2ICL3 N L M C K T D I ICL3ECL3 V M D E H A R G T ECL3N-term M A G A P S P L R L A L L L L G A V G R A G P R P Q G A T V S L S E T V Q K W R E Y R R Q C Q H F L T E A P P L A T G L F C N R T F D D Y A C W P D G A P G S F V N V S C P W Y L P W A S N V L Q G H V Y R F C T T E G H W L H K D N S S L P W R D L S E C E E S R R G E K S S N-termC-term S M K P L K C P T S S L S S G A T G G S S V Y A A T S Q A C S C-term P E E Q L L S L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q L G C R L V F L L M Q Y C V A A N Y Y W L L V E G A Y L Y T L L A F S E Q R I F K L Y L S I G W G V P L L F V I P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F I R V I C I V V S K L K A K C R L A K S T L T L I P L L G T H E V I F A F L R F V K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L V Q R V Q M E S W E R E H L R D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x29 1.33x33 E138
1x33 1.37x37 L142
TM2
2x60 2.67x67 K197
2x64 2.71x71 L201
2x67 2.74x74 M204
TM3
3x32 3.36x36 M233
ECL2
45x51 45.51x51 W297
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
TM7
7x35 7.40x39 F385
7x38 7.43x42 L388