CCR7 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Nov. 26, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

CCL19 - Agonist

PHYSIOLOGICAL LIGANDS

CCL21 (Human), CCL19 (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic TM6 A 261 6x33 G.H5 L 348 G.H5.20
Polar H8 K 332 8x49 G.H5 G 352 G.H5.24
Hydrophobic H8 K 332 8x49 G.H5 G 352 G.H5.24
Van-der-waals H8 K 332 8x49 G.H5 G 352 G.H5.24
Hydrophobic TM4 A 169 4x36 G.HN E 28 G.HN.52
Van-der-waals TM4 A 169 4x36 G.HN E 28 G.HN.52
Hydrophobic ICL2 H 165 - G.H5 I 343 G.H5.15
Hydrophobic TM6 I 265 6x37 G.H5 L 353 G.H5.25
Polar ICL2 H 165 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 165 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 158 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 158 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 250 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 250 5x65 G.H5 L 348 G.H5.20
Hydrophobic H8 V 331 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 V 331 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 158 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM6 K 260 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 260 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM5 T 249 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL3 N 255 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 N 255 - G.H5 I 344 G.H5.16
Hydrophobic TM2 T 93 2x39 G.H5 C 351 G.H5.23
Polar TM3 R 154 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 154 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 154 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 H 165 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 H 165 - G.S1 V 34 G.S1.02
Hydrophobic ICL4 I 329 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 I 329 - G.H5 G 352 G.H5.24
Hydrophobic ICL3 R 258 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 R 258 - G.H5 K 345 G.H5.17
Polar ICL2 R 166 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 166 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 166 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 A 161 - G.H5 N 347 G.H5.19
Polar ICL2 R 166 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 166 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 R 258 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 R 258 - G.H5 L 348 G.H5.20
Polar TM6 A 261 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 261 6x33 G.H5 L 353 G.H5.25
Polar ICL4 G 330 - G.H5 G 352 G.H5.24
Hydrophobic ICL4 G 330 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 G 330 - G.H5 G 352 G.H5.24
Hydrophobic ICL2 A 161 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 161 - G.H5 I 344 G.H5.16
Polar TM3 A 157 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 157 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 157 3x53 G.H5 N 347 G.H5.19
Polar ICL2 H 165 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 H 165 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 H 165 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL3 F 256 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 R 154 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 154 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 161 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 161 - G.H5 I 343 G.H5.15
Polar H8 K 332 8x49 G.H5 K 349 G.H5.21
Hydrophobic H8 K 332 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 K 332 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM3 I 158 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 158 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 A 157 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 157 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL3 N 255 - G.H5 K 345 G.H5.17
Polar ICL3 R 258 - G.H5 F 354 G.H5.26
Aromatic ICL3 R 258 - G.H5 F 354 G.H5.26
Hydrophobic ICL3 R 258 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 R 258 - G.H5 F 354 G.H5.26
Hydrophobic ICL3 E 257 - G.h4s6 T 316 G.h4s6.10
Polar ICL3 N 255 - G.H5 D 341 G.H5.13
Hydrophobic TM6 V 264 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 158 3x54 G.H5 I 344 G.H5.16