TRH1 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

Aug. 31, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

taltirelin - Agonist pubchem gtoplig chembl_ligand

ENDOGENOUS LIGANDS

TRH



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 P 130 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 130 - G.H5 I 235 G.H5.15
Hydrophobic ICL2 I 131 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 I 131 - G.H5 F 228 G.H5.08
Hydrophobic TM3 R 123 3x50 G.H5 L 245 G.H5.25
Van-der-waals TM3 R 123 3x50 G.H5 L 245 G.H5.25
Hydrophobic TM2 T 60 2x39 G.H5 Y 243 G.H5.23
Polar ICL2 F 135 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 135 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 F 135 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 V 264 6x33 G.H5 L 240 G.H5.20
Hydrophobic TM3 A 126 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 A 126 3x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 I 131 - G.H5 I 235 G.H5.15
Hydrophobic TM3 I 127 3x54 G.H5 L 240 G.H5.20
Van-der-waals TM3 I 127 3x54 G.H5 L 240 G.H5.20
Hydrophobic TM6 L 268 6x37 G.H5 L 245 G.H5.25
Polar ICL4 Q 325 - G.H5 L 245 G.H5.25
Hydrophobic ICL4 Q 325 - G.H5 L 245 G.H5.25
Van-der-waals ICL4 Q 325 - G.H5 L 245 G.H5.25
Hydrophobic ICL2 P 130 - G.H5 L 236 G.H5.16
Hydrophobic TM5 I 214 5x61 G.H5 L 245 G.H5.25
Hydrophobic ICL4 Q 325 - G.H5 R 241 G.H5.21
Hydrophobic ICL2 F 135 - G.S1 L 34 G.S1.02
Polar TM3 A 126 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM3 A 126 3x53 G.H5 N 239 G.H5.19
Van-der-waals TM3 A 126 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM3 F 119 3x46 G.H5 Y 243 G.H5.23
Polar ICL2 F 135 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 F 135 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 F 135 - G.hns1 R 31 G.hns1.02
Hydrophobic TM5 L 218 5x65 G.H5 L 240 G.H5.20
Hydrophobic H8 K 326 8x49 G.H5 R 241 G.H5.21
Van-der-waals H8 K 326 8x49 G.H5 R 241 G.H5.21
Polar TM3 E 122 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM3 E 122 3x49 G.H5 Y 243 G.H5.23
Van-der-waals TM3 E 122 3x49 G.H5 Y 243 G.H5.23
Polar TM2 T 58 2x37 G.H5 E 242 G.H5.22
Hydrophobic TM5 I 217 5x64 G.H5 L 236 G.H5.16
Polar ICL4 S 324 - G.H5 N 244 G.H5.24
Hydrophobic ICL4 S 324 - G.H5 N 244 G.H5.24
Van-der-waals ICL4 S 324 - G.H5 N 244 G.H5.24
Polar H8 K 326 8x49 G.H5 E 242 G.H5.22
Hydrophobic H8 K 326 8x49 G.H5 E 242 G.H5.22
Van-der-waals H8 K 326 8x49 G.H5 E 242 G.H5.22
Hydrophobic TM2 T 60 2x39 G.H5 E 242 G.H5.22
Van-der-waals TM2 T 60 2x39 G.H5 E 242 G.H5.22
Hydrophobic TM3 I 127 3x54 G.H5 N 239 G.H5.19
Van-der-waals TM3 I 127 3x54 G.H5 N 239 G.H5.19
Hydrophobic ICL2 I 131 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 I 131 - G.S1 L 34 G.S1.02
Polar TM7 Y 320 7x53 G.H5 N 244 G.H5.24
Hydrophobic ICL2 Q 134 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 Q 134 - G.S1 L 34 G.S1.02
Hydrophobic TM3 I 127 3x54 G.H5 L 236 G.H5.16
Van-der-waals TM3 I 127 3x54 G.H5 L 236 G.H5.16
Hydrophobic H8 F 327 8x50 G.H5 N 244 G.H5.24
Van-der-waals H8 F 327 8x50 G.H5 N 244 G.H5.24
Hydrophobic TM3 I 127 3x54 G.H5 L 245 G.H5.25
Van-der-waals TM3 I 127 3x54 G.H5 L 245 G.H5.25
Polar ICL2 C 137 - G.H5 Y 243 G.H5.23
Hydrophobic ICL2 C 137 - G.H5 Y 243 G.H5.23
Van-der-waals ICL2 C 137 - G.H5 Y 243 G.H5.23
Polar TM3 R 123 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 Y 243 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 I 131 - G.S3 V 79 G.S3.01
Van-der-waals ICL2 P 130 - G.H5 N 239 G.H5.19
Hydrophobic ICL2 I 131 - G.H5 K 232 G.H5.12
Polar TM2 T 60 2x39 G.H5 N 244 G.H5.24
Van-der-waals TM2 T 60 2x39 G.H5 N 244 G.H5.24
Hydrophobic TM6 V 264 6x33 G.H5 L 245 G.H5.25
Polar H8 K 326 8x49 G.H5 N 244 G.H5.24