PDB
7X1T
Resolution
3.3 Å
Released
Aug. 31, 2022
Receptor
TRH1
Class
A
Species
Homo sapiens
Ligand
Function
taltirelin
Agonist
Reference
10.1038/S41422-022-00646-6

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Ligand Amino Acid Generic Number Segment Interaction Type
taltirelin A78 2.57x56 TM2 hydrophobic
taltirelin T102 3.29x29 TM3 Van der Waals
taltirelin Q105 3.32x32 TM3 hydrophobic
taltirelin Y106 3.33x33 TM3 aromatic (edge-to-face)
taltirelin Y106 3.33x33 TM3 polar (hydrogen bond)
taltirelin I109 3.36x36 TM3 hydrophobic
taltirelin L164 ECL2 Van der Waals
taltirelin C179 45.50x50 ECL2 Van der Waals
taltirelin Y181 45.52x52 ECL2 aromatic (edge-to-face)
taltirelin R185 5.32x32 TM5 polar (hydrogen bond)
taltirelin Y282 6.51x51 TM6 polar (hydrogen bond)
taltirelin V286 6.55x55 TM6 hydrophobic
taltirelin N289 6.58x58 TM6 polar (hydrogen bond)
taltirelin L302 7.35x34 TM7 Van der Waals
taltirelin R306 7.39x38 TM7 Van der Waals
taltirelin Y310 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 K H M R ICL1ECL1 G S W V Y ECL1ICL2 P I K A Q F L C ICL2ECL2 D L N I S T Y K D A I V I S C G Y K ECL2ICL3 N S K T W K N D S T H Q N T N L N V N T S N R C F ICL3ECL3 S S P F Q ECL3N-term M E N E T V S E L N Q T Q L Q P R A V V A N-termC-term C K Q K P T E K P A N Y S V A L N Y S V I K E S D H F S T E L D D I T V T D T Y L S A T K V S F D D T C L A S E V S F S Q S C-term L E Y Q V V T I L L V L I I C G L G I V G N I M V V L V V M R T T P T N C Y L V S L A V A D L M V L V A A G L P N I T D S I Y G Y V G C L C I T Y L Q Y L G I N A S S C S I T A F T I E R Y I A I C H T F S R A K K I I I F V W A F T S L Y C M L W F F L L I S R N Y Y S P I Y L M D F G V F Y V V P M I L A T V L Y G F I A R I L F L N P I P S D P K E N S T V S S R K Q V T K M L A V V V I L F A L L W M P Y R T L V V V N S F L E N W F L L F C R I C I Y L N S A I N P V I Y N L M S Q K F R K F R A A L C N
Helix box plot — Download: PNG | SVG I N G V I G L G C I I L V L L I T V V Q 1 V S L A V A D L M V L A V A G L P N I T D 2 A T I S C S S A N I G L Y Q L Y T I C L 3 A K K I I I F V W A F T S L Y C M L W F 4 Y L V T A L I M P V V Y F V G F D M L Y 5 A V V V I L F A L L W M P Y R T L V V V 6 V P N I A S N L Y I C I R C F L L F W 7

GPCRdb(A)
GPCRdb(A)
TRH1 receptor
TM2
2x56 2.57x56 A78
TM3
3x29 3.29x29 T102
3x32 3.32x32 Q105
3x33 3.33x33 Y106
3x36 3.36x36 I109
ECL2
45x50 45.50x50 C179
45x52 45.52x52 Y181
TM5
5x32 5.32x32 R185
TM6
6x51 6.51x51 Y282
6x55 6.55x55 V286
6x58 6.58x58 N289
TM7
7x34 7.35x34 L302
7x38 7.39x38 R306
7x42 7.43x42 Y310