UT receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Dec. 3, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

P5U - Agonist

PHYSIOLOGICAL LIGANDS

urotensin II-related peptide (Human), urotensin-II (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Van-der-waals TM2 S 85 2x38 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 L 156 34x51 G.H5 K 232 G.H5.12
Van-der-waals ICL2 L 156 34x51 G.H5 K 232 G.H5.12
Hydrophobic ICL3 Q 242 - G.H5 L 236 G.H5.16
Polar ICL3 Q 242 - G.H5 D 233 G.H5.13
Hydrophobic ICL3 Q 242 - G.H5 D 233 G.H5.13
Van-der-waals ICL3 Q 242 - G.H5 D 233 G.H5.13
Polar TM2 A 84 2x37 G.H5 E 242 G.H5.22
Hydrophobic TM2 A 84 2x37 G.H5 E 242 G.H5.22
Van-der-waals TM2 A 84 2x37 G.H5 E 242 G.H5.22
Hydrophobic TM5 Y 238 5x65 G.H5 L 240 G.H5.20
Van-der-waals TM5 Y 238 5x65 G.H5 L 240 G.H5.20
Polar TM3 R 148 3x50 G.H5 N 244 G.H5.24
Van-der-waals TM3 R 148 3x50 G.H5 N 244 G.H5.24
Hydrophobic ICL2 Q 160 34x55 G.S3 V 79 G.S3.01
Van-der-waals ICL2 Q 160 34x55 G.S3 V 79 G.S3.01
Polar ICL2 T 158 34x53 G.H5 N 239 G.H5.19
Van-der-waals TM7 Y 315 7x53 G.H5 N 244 G.H5.24
Polar TM2 S 85 2x38 G.H5 E 242 G.H5.22
Hydrophobic TM2 S 85 2x38 G.H5 E 242 G.H5.22
Van-der-waals TM2 S 85 2x38 G.H5 E 242 G.H5.22
Hydrophobic ICL2 V 159 34x54 G.H5 I 235 G.H5.15
Van-der-waals ICL2 V 159 34x54 G.H5 I 235 G.H5.15
Hydrophobic TM5 L 234 5x61 G.H5 L 245 G.H5.25
Polar ICL3 Q 242 - G.H5 Q 237 G.H5.17
Hydrophobic ICL3 Q 242 - G.H5 Q 237 G.H5.17
Van-der-waals ICL3 Q 242 - G.H5 Q 237 G.H5.17
Hydrophobic H8 T 319 8x47 G.H5 N 244 G.H5.24
Van-der-waals H8 T 319 8x47 G.H5 N 244 G.H5.24
Hydrophobic ICL2 P 155 34x50 G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 155 34x50 G.H5 I 235 G.H5.15
Hydrophobic H8 R 320 8x48 G.h4s6 R 208 G.h4s6.12
Van-der-waals H8 R 320 8x48 G.h4s6 R 208 G.h4s6.12
Hydrophobic TM3 V 152 3x54 G.H5 L 240 G.H5.20
Polar H8 N 321 8x49 G.H5 R 241 G.H5.21
Hydrophobic ICL2 L 156 34x51 G.H5 F 228 G.H5.08
Van-der-waals ICL2 L 156 34x51 G.H5 F 228 G.H5.08
Hydrophobic TM3 V 152 3x54 G.H5 L 245 G.H5.25
Polar ICL2 P 155 34x50 G.H5 N 239 G.H5.19
Van-der-waals ICL2 P 155 34x50 G.H5 N 239 G.H5.19
Polar TM3 A 151 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM3 A 151 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM2 M 86 2x39 G.H5 Y 243 G.H5.23
Van-der-waals TM2 M 86 2x39 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 V 159 34x54 G.H5 N 239 G.H5.19
Van-der-waals ICL2 V 159 34x54 G.H5 N 239 G.H5.19
Polar TM4 R 166 4x42 G.H5 Y 243 G.H5.23
Van-der-waals TM4 R 166 4x42 G.H5 Y 243 G.H5.23
Polar TM3 R 148 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 148 3x50 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 P 155 34x50 G.H5 K 232 G.H5.12
Hydrophobic TM3 A 151 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 A 151 3x53 G.H5 Y 243 G.H5.23
Hydrophobic TM6 R 258 6x35 G.H5 V 246 G.H5.26
Van-der-waals TM6 R 258 6x35 G.H5 V 246 G.H5.26
Hydrophobic TM3 R 148 3x50 G.H5 L 245 G.H5.25
Hydrophobic ICL2 P 155 34x50 G.H5 L 236 G.H5.16
Hydrophobic ICL2 L 156 34x51 G.H5 I 235 G.H5.15
Van-der-waals ICL2 L 156 34x51 G.H5 I 235 G.H5.15
Hydrophobic TM3 E 147 3x49 G.H5 Y 243 G.H5.23
Polar ICL2 Q 160 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 160 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 160 34x55 G.hns1 R 32 G.hns1.03