PDB
9JFK
Resolution
3.2 Å
Released
Dec. 3, 2025
Receptor
UT
Class
A
Species
Homo sapiens
Ligand
P5U
Function
Agonist
Reference
10.1016/J.JBC.2025.110794

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Ligand Amino Acid Generic Number Segment Interaction Type
P5U Y100 2.53x53 TM2 polar (hydrogen bond)
P5U I107 2.60x60 TM2 Van der Waals
P5U I107 2.60x60 TM2 hydrophobic
P5U L126 3.28x28 TM3 hydrophobic
P5U L126 3.28x28 TM3 Van der Waals
P5U F127 3.29x29 TM3 Van der Waals
P5U F127 3.29x29 TM3 hydrophobic
P5U D130 3.32x32 TM3 polar (charge-assisted hydrogen bond)
P5U F131 3.33x33 TM3 Van der Waals
P5U F131 3.33x33 TM3 hydrophobic
P5U L198 ECL2 hydrophobic
P5U L198 ECL2 Van der Waals
P5U C199 45.50x50 ECL2 Van der Waals
P5U L200 45.51x51 ECL2 Van der Waals
P5U L200 45.51x51 ECL2 hydrophobic
P5U P201 45.52x52 ECL2 hydrophobic
P5U P201 45.52x52 ECL2 Van der Waals
P5U L212 5.39x40 TM5 Van der Waals
P5U L212 5.39x40 TM5 hydrophobic
P5U W277 6.54x54 TM6 aromatic (face-to-edge)
P5U W277 6.54x54 TM6 Van der Waals
P5U L280 6.57x57 TM6 hydrophobic
P5U L280 6.57x57 TM6 Van der Waals
P5U Y283 6.60x60 TM6 polar (hydrogen bond)
P5U R294 7.32x31 TM7 polar (charge-assisted hydrogen bond)
P5U N297 7.35x34 TM7 polar (hydrogen bond)
P5U N297 7.35x34 TM7 polar (hydrogen bond)
P5U Y298 7.36x35 TM7 Van der Waals
P5U T301 7.39x38 TM7 Van der Waals
P5U Y305 7.43x42 TM7 polar (hydrogen bond)

P5U

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Snake plot — Download: PNG | SVG
ICL1 L R A V ICL1ECL1 K E W H F ECL1ICL2 P L D T V Q R ICL2ECL2 R L V R R G P K S L C L P A ECL2ICL3 R A S ICL3ECL3 Q ECL3N-term M A L T P E S P S S F P G L A A T G S S V P E P P G G P N A T L N S S W A S P T E P N-termC-term P G S G G G R G P V P S L Q P R A R F Q R C S G R S L S S C S P Q P T D S L V L A P A A P A R P A P E G P R A P A C-term S S L E D L V A T G T I G T L L S A M G V V G V V G N A Y T L V V T C R S A S M Y V Y V V N L A L A D L L Y L L S I P F I V A T Y V T G D V G C R V L F G L D F L T M H A S I F T L T V M S S E R Y A A V L R P K G Y R K L L A L G T W L L A L L L T L P V M L A M W G P R A H R A Y L T L L F A T S I A G P G L L I G L L Y A R L A R A Y R R S Q F K R A R R P G A R A L R L V L G I V L L F W A C F L P F W L W Q L L A Q Y H A P L A P R T A R I V N Y L T T C L T Y G N S C A N P F L Y T L L T R N L R G Y R D H R V R G
Helix box plot — Download: PNG | SVG A N G V V G V V G M A S L L T G I T G T 1 V N L A L A D L L Y L L S I P F I V A T 2 V T L T F I S A H M T L F D L G F L V R 3 R K L L A L G T W L L A L L L T L P V 4 Y L L G I L L G P G A I S T A F L L T L Y 5 L G I V L L F W A C F L P F W L W Q L L 6 F P N A C S N G Y T L C T T L Y N V I 7

GPCRdb(A)
GPCRdb(A)
UT receptor
TM2
2x53 2.53x53 Y100
2x60 2.60x60 I107
TM3
3x28 3.28x28 L126
3x29 3.29x29 F127
3x32 3.32x32 D130
3x33 3.33x33 F131
ECL2
45x50 45.50x50 C199
45x51 45.51x51 L200
45x52 45.52x52 P201
TM5
5x40 5.39x40 L212
TM6
6x54 6.54x54 W277
6x57 6.57x57 L280
6x60 6.60x60 Y283
TM7
7x31 7.32x31 R294
7x34 7.35x34 N297
7x35 7.36x35 Y298
7x38 7.39x38 T301
7x42 7.43x42 Y305