Refined structure (8VHF) of Gs - GPR119

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-12-20

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 237 from structure (60.2%), 157 from model (39.8%)
Residue sidechains - 227 from structure (57.6%), 167 from model (42.4%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 Structure Structure
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure Structure
G.s1h1 50 E G.s1h1.04 Structure Structure
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure AF2
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure Structure
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 Structure Structure
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 Structure Structure
G.s4h3 259 E G.s4h3.10 Structure AF2
G.s4h3 260 D G.s4h3.11 Structure AF2
G.s4h3 261 N G.s4h3.12 Structure Structure
G.s4h3 262 Q G.s4h3.13 Structure Structure
G.s4h3 263 T G.s4h3.14 Structure Structure
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure AF2
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure AF2
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure AF2
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure AF2
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure AF2
G.h3s5 285 I G.h3s5.03 Structure AF2
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure Structure
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 295 from structure (96.7%), 10 from model (3.3%)
Residue sidechains - 295 from structure (96.7%), 10 from model (3.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
TM1 1 M 1.29x29 AF2 AF2
TM1 2 E 1.30x30 AF2 AF2
TM1 3 S 1.31x31 AF2 AF2
TM1 4 S 1.32x32 AF2 AF2
TM1 5 F 1.33x33 AF2 AF2
TM1 6 S 1.34x34 Structure Structure
TM1 7 F 1.35x35 Structure Structure
TM1 8 G 1.36x36 Structure Structure
TM1 9 V 1.37x37 Structure Structure
TM1 10 I 1.38x38 Structure Structure
TM1 11 L 1.39x39 Structure Structure
TM1 12 A 1.40x40 Structure Structure
TM1 13 V 1.41x41 Structure Structure
TM1 14 L 1.42x42 Structure Structure
TM1 15 A 1.43x43 Structure Structure
TM1 16 S 1.44x44 Structure Structure
TM1 17 L 1.45x45 Structure Structure
TM1 18 I 1.46x46 Structure Structure
TM1 19 I 1.47x47 Structure Structure
TM1 20 A 1.48x48 Structure Structure
TM1 21 T 1.49x49 Structure Structure
TM1 22 N 1.50x50 Structure Structure
TM1 23 T 1.51x51 Structure Structure
TM1 24 L 1.52x52 Structure Structure
TM1 25 V 1.53x53 Structure Structure
TM1 26 A 1.54x54 Structure Structure
TM1 27 V 1.55x55 Structure Structure
TM1 28 A 1.56x56 Structure Structure
TM1 29 V 1.57x57 Structure Structure
TM1 30 L 1.58x58 Structure Structure
TM1 31 L 1.59x59 Structure Structure
TM1 32 L 1.60x60 Structure Structure
ICL1 33 I - Structure Structure
ICL1 34 H - Structure Structure
ICL1 35 K - Structure Structure
ICL1 36 N - Structure Structure
ICL1 37 D - Structure Structure
TM2 38 G 2.37x37 Structure Structure
TM2 39 V 2.38x38 Structure Structure
TM2 40 S 2.39x39 Structure Structure
TM2 41 L 2.40x40 Structure Structure
TM2 42 C 2.41x41 Structure Structure
TM2 43 F 2.42x42 Structure Structure
TM2 44 T 2.43x43 Structure Structure
TM2 45 L 2.44x44 Structure Structure
TM2 46 N 2.45x45 Structure Structure
TM2 47 L 2.46x46 Structure Structure
TM2 48 A 2.47x47 Structure Structure
TM2 49 V 2.48x48 Structure Structure
TM2 50 A 2.49x49 Structure Structure
TM2 51 D 2.50x50 Structure Structure
TM2 52 T 2.51x51 Structure Structure
TM2 53 L 2.52x52 Structure Structure
TM2 54 I 2.53x53 Structure Structure
TM2 55 G 2.54x54 Structure Structure
TM2 56 V 2.55x55 Structure Structure
TM2 57 A 2.56x56 Structure Structure
TM2 58 I 2.57x57 Structure Structure
TM2 59 S 2.58x58 Structure Structure
TM2 60 G 2.59x59 Structure Structure
TM2 61 L 2.60x60 Structure Structure
TM2 62 L 2.61x61 Structure Structure
TM2 63 T 2.62x62 Structure Structure
TM2 64 D 2.63x63 Structure Structure
TM2 65 Q 2.64x64 Structure Structure
TM2 66 L 2.65x65 Structure Structure
TM2 67 S 2.66x66 Structure Structure
ECL1 68 S - Structure Structure
ECL1 69 P - Structure Structure
ECL1 70 S - Structure Structure
TM3 71 R 3.18x18 Structure Structure
TM3 72 P 3.19x19 Structure Structure
TM3 73 T 3.20x20 Structure Structure
TM3 74 Q 3.21x21 Structure Structure
TM3 75 K 3.22x22 Structure Structure
TM3 76 T 3.23x23 Structure Structure
TM3 77 L 3.24x24 Structure Structure
TM3 78 C 3.25x25 Structure Structure
TM3 79 S 3.26x26 Structure Structure
TM3 80 L 3.27x27 Structure Structure
TM3 81 R 3.28x28 Structure Structure
TM3 82 M 3.29x29 Structure Structure
TM3 83 A 3.30x30 Structure Structure
TM3 84 F 3.31x31 Structure Structure
TM3 85 V 3.32x32 Structure Structure
TM3 86 T 3.33x33 Structure Structure
TM3 87 S 3.34x34 Structure Structure
TM3 88 S 3.35x35 Structure Structure
TM3 89 A 3.36x36 Structure Structure
TM3 90 A 3.37x37 Structure Structure
TM3 91 A 3.38x38 Structure Structure
TM3 92 S 3.39x39 Structure Structure
TM3 93 V 3.40x40 Structure Structure
TM3 94 L 3.41x41 Structure Structure
TM3 95 T 3.42x42 Structure Structure
TM3 96 V 3.43x43 Structure Structure
TM3 97 M 3.44x44 Structure Structure
TM3 98 L 3.45x45 Structure Structure
TM3 99 I 3.46x46 Structure Structure
TM3 100 T 3.47x47 Structure Structure
TM3 101 F 3.48x48 Structure Structure
TM3 102 D 3.49x49 Structure Structure
TM3 103 R 3.50x50 Structure Structure
TM3 104 Y 3.51x51 Structure Structure
TM3 105 L 3.52x52 Structure Structure
TM3 106 A 3.53x53 Structure Structure
TM3 107 I 3.54x54 Structure Structure
TM3 108 K 3.55x55 Structure Structure
TM3 109 Q 3.56x56 Structure Structure
ICL2 110 P 34.50x50 Structure Structure
ICL2 111 F 34.51x51 Structure Structure
ICL2 112 R 34.52x52 Structure Structure
ICL2 113 Y 34.53x53 Structure Structure
ICL2 114 L 34.54x54 Structure Structure
ICL2 115 K 34.55x55 Structure Structure
ICL2 116 I 34.56x56 Structure Structure
ICL2 117 M 34.57x57 Structure Structure
TM4 118 S 4.38x38 Structure Structure
TM4 119 G 4.39x39 Structure Structure
TM4 120 F 4.40x40 Structure Structure
TM4 121 V 4.41x41 Structure Structure
TM4 122 A 4.42x42 Structure Structure
TM4 123 G 4.43x43 Structure Structure
TM4 124 A 4.44x44 Structure Structure
TM4 125 C 4.45x45 Structure Structure
TM4 126 I 4.46x46 Structure Structure
TM4 127 A 4.47x47 Structure Structure
TM4 128 G 4.48x48 Structure Structure
TM4 129 L 4.49x49 Structure Structure
TM4 130 W 4.50x50 Structure Structure
TM4 131 L 4.51x51 Structure Structure
TM4 132 V 4.52x52 Structure Structure
TM4 133 S 4.53x53 Structure Structure
TM4 134 Y 4.54x54 Structure Structure
TM4 135 L 4.55x55 Structure Structure
TM4 136 I 4.56x56 Structure Structure
TM4 137 G 4.57x57 Structure Structure
TM4 138 F 4.58x58 Structure Structure
TM4 139 L 4.59x59 Structure Structure
TM4 140 P 4.60x60 Structure Structure
TM4 141 L 4.61x61 Structure Structure
TM4 142 G 4.62x62 Structure Structure
TM4 143 I 4.63x63 Structure Structure
ECL2 144 P - Structure Structure
ECL2 145 M - Structure Structure
ECL2 146 F - Structure Structure
ECL2 147 Q - Structure Structure
ECL2 148 Q - Structure Structure
ECL2 149 T - Structure Structure
ECL2 150 A - Structure Structure
ECL2 151 Y - Structure Structure
ECL2 152 K - Structure Structure
ECL2 153 G - Structure Structure
ECL2 154 Q - Structure Structure
ECL2 155 C 45.50x50 Structure Structure
ECL2 156 S 45.51x51 Structure Structure
ECL2 157 F 45.52x52 Structure Structure
ECL2 158 F - Structure Structure
ECL2 159 A - Structure Structure
ECL2 160 V - Structure Structure
TM5 161 F 5.35x36 Structure Structure
TM5 162 H 5.36x37 Structure Structure
TM5 163 P 5.37x38 Structure Structure
TM5 164 H 5.38x39 Structure Structure
TM5 165 F 5.39x40 Structure Structure
TM5 166 V 5.40x41 Structure Structure
TM5 167 L 5.41x42 Structure Structure
TM5 168 T 5.42x43 Structure Structure
TM5 169 L 5.43x44 Structure Structure
TM5 170 S 5.44x45 Structure Structure
TM5 171 C 5.45x46 Structure Structure
TM5 172 V 5.46x461 Structure Structure
TM5 173 G 5.47x47 Structure Structure
TM5 174 F 5.48x48 Structure Structure
TM5 175 F 5.49x49 Structure Structure
TM5 176 P 5.50x50 Structure Structure
TM5 177 A 5.51x51 Structure Structure
TM5 178 M 5.52x52 Structure Structure
TM5 179 L 5.53x53 Structure Structure
TM5 180 L 5.54x54 Structure Structure
TM5 181 F 5.55x55 Structure Structure
TM5 182 V 5.56x56 Structure Structure
TM5 183 F 5.57x57 Structure Structure
TM5 184 F 5.58x58 Structure Structure
TM5 185 Y 5.59x59 Structure Structure
TM5 186 C 5.60x60 Structure Structure
TM5 187 D 5.61x61 Structure Structure
TM5 188 M 5.62x62 Structure Structure
TM5 189 L 5.63x63 Structure Structure
TM5 190 K 5.64x64 Structure Structure
TM5 191 I 5.65x65 Structure Structure
TM5 192 A 5.66x66 Structure Structure
TM5 193 S 5.67x67 Structure Structure
TM5 194 M 5.68x68 Structure Structure
TM5 195 H 5.69x69 Structure Structure
TM5 196 S 5.70x70 Structure Structure
TM5 197 Q 5.71x71 Structure Structure
TM5 198 Q 5.72x72 Structure Structure
TM5 199 I 5.73x73 Structure Structure
TM5 200 R 5.74x74 Structure Structure
TM5 201 K 5.75x75 Structure Structure
TM5 202 M 5.76x76 Structure Structure
TM5 203 E 5.77x77 Structure Structure
TM5 204 H 5.78x78 Structure Structure
TM5 205 A 5.79x79 Structure Structure
TM5 206 G 5.80x80 Structure Structure
ICL3 207 A - Structure Structure
ICL3 208 M - Structure Structure
ICL3 209 A - Structure Structure
ICL3 210 G - Structure Structure
ICL3 211 G - Structure Structure
ICL3 212 Y - Structure Structure
TM6 213 R 6.23x23 Structure Structure
TM6 214 S 6.24x24 Structure Structure
TM6 215 P 6.25x25 Structure Structure
TM6 216 R 6.26x26 Structure Structure
TM6 217 T 6.27x27 Structure Structure
TM6 218 P 6.28x28 Structure Structure
TM6 219 S 6.29x29 Structure Structure
TM6 220 D 6.30x30 Structure Structure
TM6 221 F 6.31x31 Structure Structure
TM6 222 K 6.32x32 Structure Structure
TM6 223 A 6.33x33 Structure Structure
TM6 224 L 6.34x34 Structure Structure
TM6 225 R 6.35x35 Structure Structure
TM6 226 T 6.36x36 Structure Structure
TM6 227 V 6.37x37 Structure Structure
TM6 228 S 6.38x38 Structure Structure
TM6 229 V 6.39x39 Structure Structure
TM6 230 L 6.40x40 Structure Structure
TM6 231 I 6.41x41 Structure Structure
TM6 232 G 6.42x42 Structure Structure
TM6 233 S 6.43x43 Structure Structure
TM6 234 F 6.44x44 Structure Structure
TM6 235 A 6.45x45 Structure Structure
TM6 236 L 6.46x46 Structure Structure
TM6 237 S 6.47x47 Structure Structure
TM6 238 W 6.48x48 Structure Structure
TM6 239 T 6.49x49 Structure Structure
TM6 240 P 6.50x50 Structure Structure
TM6 241 F 6.51x51 Structure Structure
TM6 242 L 6.52x52 Structure Structure
TM6 243 I 6.53x53 Structure Structure
TM6 244 T 6.54x54 Structure Structure
TM6 245 G 6.55x55 Structure Structure
TM6 246 I 6.56x56 Structure Structure
TM6 247 V 6.57x57 Structure Structure
TM6 248 Q 6.58x58 Structure Structure
TM6 249 V 6.59x59 Structure Structure
TM6 250 A 6.60x60 Structure Structure
TM6 251 C 6.61x61 Structure Structure
ECL3 252 Q - Structure Structure
ECL3 253 E - Structure Structure
ECL3 254 C - Structure Structure
ECL3 255 H - Structure Structure
ECL3 256 L - Structure Structure
TM7 257 Y 7.31x30 Structure Structure
TM7 258 L 7.32x31 Structure Structure
TM7 259 V 7.33x32 Structure Structure
TM7 260 L 7.34x33 Structure Structure
TM7 261 E 7.35x34 Structure Structure
TM7 262 R 7.36x35 Structure Structure
TM7 263 Y 7.37x36 Structure Structure
TM7 264 L 7.38x37 Structure Structure
TM7 265 W 7.39x38 Structure Structure
TM7 266 L 7.40x39 Structure Structure
TM7 267 L 7.41x40 Structure Structure
TM7 268 G 7.42x41 Structure Structure
TM7 269 V 7.43x42 Structure Structure
TM7 270 G 7.44x43 Structure Structure
TM7 271 N 7.45x45 Structure Structure
TM7 272 S 7.46x46 Structure Structure
TM7 273 L 7.47x47 Structure Structure
TM7 274 L 7.48x48 Structure Structure
TM7 275 N 7.49x49 Structure Structure
TM7 276 P 7.50x50 Structure Structure
TM7 277 L 7.51x51 Structure Structure
TM7 278 I 7.52x52 Structure Structure
TM7 279 Y 7.53x53 Structure Structure
TM7 280 A 7.54x54 Structure Structure
TM7 281 Y 7.55x55 Structure Structure
TM7 282 W 7.56x56 Structure Structure
H8 283 Q 8.47x47 Structure Structure
H8 284 K 8.48x48 Structure Structure
H8 285 E 8.49x49 Structure Structure
H8 286 V 8.50x50 Structure Structure
H8 287 R 8.51x51 Structure Structure
H8 288 L 8.52x52 Structure Structure
H8 289 Q 8.53x53 Structure Structure
H8 290 L 8.54x54 Structure Structure
H8 291 Y 8.55x55 Structure Structure
H8 292 H 8.56x56 Structure Structure
H8 293 M 8.57x57 Structure Structure
H8 294 A 8.58x58 Structure Structure
H8 295 L 8.59x59 Structure Structure
C-term 296 G - Structure Structure
C-term 297 V - Structure Structure
C-term 298 K - Structure Structure
C-term 299 K - Structure Structure
C-term 300 V - Structure Structure
C-term 301 L - AF2 AF2
C-term 302 T - AF2 AF2
C-term 303 S - AF2 AF2
C-term 304 F - AF2 AF2
C-term 305 L - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM5 G 206 5x80 G.H4 L 346 G.H4.16
Hydrophobic TM5 A 192 5x66 G.H5 L 388 G.H5.20
Ionic TM5 H 204 5x78 G.hgh4 E 322 G.hgh4.12
Polar TM5 H 204 5x78 G.hgh4 E 322 G.hgh4.12
Ionic ICL1 D 37 - G.HN K 34 G.HN.51
Hydrophobic TM5 A 205 5x79 G.H4 D 343 G.H4.13
Van-der-waals TM5 A 205 5x79 G.H4 D 343 G.H4.13
Ionic TM6 K 222 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 222 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 222 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 222 6x32 G.H5 E 392 G.H5.24
Polar ICL2 M 117 34x57 G.hns1 R 38 G.hns1.02
Polar TM6 T 226 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 226 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 226 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 111 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 111 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM5 E 203 5x77 G.h4s6 T 350 G.h4s6.03
Polar TM6 A 223 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 223 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 223 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 111 34x51 G.H5 C 379 G.H5.11
Van-der-waals ICL2 F 111 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 M 202 5x76 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 K 222 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 222 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 110 34x50 G.H5 Q 384 G.H5.16
Aromatic TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Polar ICL2 K 115 34x55 G.HN Q 35 G.HN.52
Polar TM5 H 195 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 195 5x69 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 195 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 M 202 5x76 G.S6 P 361 G.S6.03
Hydrophobic ICL2 P 110 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM5 M 188 5x62 G.H5 L 393 G.H5.25
Hydrophobic TM7 W 282 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 107 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 107 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 107 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 S 196 5x70 G.H5 L 394 G.H5.26
Hydrophobic ICL3 A 209 - G.H4 R 347 G.H4.17
Hydrophobic ICL3 A 209 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 A 209 - G.H4 D 343 G.H4.13
Hydrophobic TM5 I 199 5x73 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 199 5x73 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 P 110 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 110 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM6 V 227 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM5 H 195 5x69 G.H5 D 381 G.H5.13
Hydrophobic ICL2 L 114 34x54 G.S1 H 41 G.S1.02
Hydrophobic TM5 M 202 5x76 G.H4 L 346 G.H4.16
Van-der-waals TM5 M 202 5x76 G.H4 L 346 G.H4.16
Hydrophobic TM3 I 107 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 107 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 111 34x51 G.S3 F 219 G.S3.03
Van-der-waals ICL2 F 111 34x51 G.S3 F 219 G.S3.03
Hydrophobic ICL3 A 209 - G.hgh4 Y 318 G.hgh4.08
Van-der-waals ICL3 A 209 - G.hgh4 Y 318 G.hgh4.08
Hydrophobic TM5 H 195 5x69 G.H5 L 388 G.H5.20
Hydrophobic TM5 M 202 5x76 G.S6 C 359 G.S6.01
Van-der-waals TM5 M 202 5x76 G.S6 C 359 G.S6.01
Polar TM4 S 118 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM4 S 118 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 S 118 4x38 G.HN Q 35 G.HN.52
Hydrophobic ICL2 F 111 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 111 34x51 G.H5 I 383 G.H5.15
Polar H8 Q 283 8x47 G.H5 Q 390 G.H5.22
Hydrophobic H8 Q 283 8x47 G.H5 Q 390 G.H5.22
Van-der-waals H8 Q 283 8x47 G.H5 Q 390 G.H5.22
Hydrophobic TM5 H 195 5x69 G.H5 L 394 G.H5.26
Hydrophobic ICL2 F 111 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 111 34x51 G.S3 V 217 G.S3.01
Polar TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM5 I 199 5x73 G.H5 L 394 G.H5.26
Polar TM3 A 106 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 106 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 106 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL3 G 210 - G.H4 R 347 G.H4.17
Van-der-waals ICL3 G 210 - G.H4 R 347 G.H4.17
Hydrophobic ICL2 K 115 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM6 T 226 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 191 5x65 G.H5 L 388 G.H5.20
Polar TM3 K 108 3x55 G.H5 Q 384 G.H5.16
Aromatic ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 I 199 5x73 G.H5 R 385 G.H5.17
Polar ICL2 L 114 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 F 111 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 111 34x51 G.H5 F 376 G.H5.08