mGlu4 receptor - Gi3

GPCR CLASS (FAMILY)

Class C (Glutamate)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

S

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

June 21, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

VU0364770 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

L-glutamic acid, L-serine-O-phosphate



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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