Structure information

mGlu4 receptor

PROTEIN CLASS

Class C (Glutamate)

PDB CODE

8JD6

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

S

REFERENCE

10.1038/S41422-023-00830-2

PUBLICATION DATE

June 21, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
VU0364770 W587 N-term hydrophobic
VU0364770 L590 1.42x42 TM1 hydrophobic
VU0364770 I804 6.56x56 TM6 hydrophobic
VU0364770 V824 7.34x35 TM7 hydrophobic
VU0364770 S825 7.35x36 TM7 Van der Waals
VU0364770 S825 7.35x36 TM7 polar (hydrogen bond)
VU0364770 L828 7.38x39 TM7 Van der Waals
VU0364770 L828 7.38x39 TM7 hydrophobic

Ligands

VU0364770

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Residue Diagrams

L T A A I G V V A L F L P L V A W P 1 Y V L L A G I F L C Y A T T F L M I 2 T L L A A Y S I S M G L G L F I R R L S 3 Q L A I T F S L I S L Q L L G I C V W F 4 A Y V T C T V M L L M S Y G L L C I L S 5 G F T M Y T T C I V W L A F I P I F F G 6 G L S V S A S L S V S V T L T T T Q I Y 7
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ICL1 T N D P I V K A S ICL1ECL1 A E P ECL1ICL2 V S A P R F I ICL2ECL2 P S H S V V D F Q D Q R T L D P R F A R G V L K C D I ECL2ICL3 R G V P E T F N E ICL3ECL3 A D ECL3N-term M P G K R G L G W W W A R L P L C L L L S L Y G P W M P S S L G K P K G H P H M N S I R I D G D I T L G G L F P V H G R G S E G K P C G E L K K E K G I H R L E A M L F A L D R I N N D P D L L P N I T L G A R I L D T C S R D T H A L E Q S L T F V Q A L I E K D G T E V R C G S G G P P I I T K P E R V V G V I G A S G S S V S I M V A N I L R L F K I P Q I S Y A S T A P D L S D N S R Y D F F S R V V P S D T Y Q A Q A M V D I V R A L K W N Y V S T V A S E G S Y G E S G V E A F I Q K S R E D G G V C I A Q S V K I P R E P K A G E F D K I I R R L L E T S N A R A V I I F A N E D D I R R V L E A A R R A N Q T G H F F W M G S D S W G S K I A P V L H L E E V A E G A V T I L P K R M S V R G F D R Y F S S R T L D N N R R N I W F A E F W E D N F H C K L S R H A L K K G S H V K K C T N R E R I G Q D S A Y E Q E G K V Q F V I D A V Y A M G H A L H A M H R D L C P G R V G L C P R M D P V D G T Q L L K Y I R N V N F S G I A G N P V T F N E N G D A P G R Y D I Y Q Y Q L R N D S A E Y K V I G S W T D H L H L R I E R M H W P G S G Q Q L P R S I C S L P C Q P G E R K K T V K G M P C C W H C E P C T G Y Q Y Q V D R Y T C K T C P Y D M R P T E N R T G C R P I P I I K L E W G S N-termC-term K A V V T A A T M S N K F T Q K G N F R P N G E A K S E L C E N L E A P A L A T K Q T Y V T Y T N H A I C-term P W A V L P L F L A V V G I A A T L F V V I T F V R Y G R E L S Y V L L A G I F L C Y A T T F L M I D L G T C S L R R I F L G L G M S I S Y A A L L T K T N R I Y R I F E Q G K R S S P A S Q L A I T F S L I S L Q L L G I C V W F V V D S D L S L I C L L G Y S M L L M V T C T V Y A I K T A K P I G F T M Y T T C I V W L A F I P I F F G T S Q S K L Y I Q T T T L T V S V S L S A S V S L G M L Y M P K V Y I I L F H P E Q R K R N V P K S L
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Residue Table


GPCRdb(A)
GPCRdb(C)
mGlu4 receptor
TM1
1x38 1.42x42 L590
TM6
6x54 6.56x56 I804
TM7
7x40 7.34x35 V824
7x41 7.35x36 S825
7x44 7.38x39 L828