CCK1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7EZK

RESOLUTION

3.1 Å

REFERENCE

10.1038/S41589-021-00841-3

PUBLICATION DATE

Aug. 25, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

78 interactions (Click to see)

LIGANDS

CCK-8 - Agonist pubchem gtoplig chembl_ligand drug_central drugbank

PHYSIOLOGICAL LIGANDS

CCK-8, desulfated cholecystokinin-8, CCK-39, CCK-58, CCK-33, CCK-4, gastrin-17



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 143 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 355 G.H5.20
Aromatic TM3 R 139 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 P 146 34x50 G.H5 I 350 G.H5.15
Hydrophobic TM6 A 307 6x29 G.H5 E 359 G.H5.24
Van-der-waals TM6 A 307 6x29 G.H5 E 359 G.H5.24
Hydrophobic ICL2 V 151 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic TM6 M 314 6x36 G.H5 L 360 G.H5.25
Van-der-waals TM6 M 314 6x36 G.H5 L 360 G.H5.25
Hydrophobic ICL2 L 147 34x51 G.S3 F 196 G.S3.03
Polar TM4 T 154 4x38 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 L 147 34x51 G.H5 F 343 G.H5.08
Van-der-waals ICL2 L 147 34x51 G.H5 F 343 G.H5.08
Hydrophobic ICL2 P 146 34x50 G.H5 Q 351 G.H5.16
Hydrophobic TM5 L 236 5x65 G.H5 L 355 G.H5.20
Hydrophobic ICL2 V 151 34x55 G.hns1 A 32 G.hns1.03
Van-der-waals ICL2 V 151 34x55 G.hns1 A 32 G.hns1.03
Hydrophobic ICL2 P 146 34x50 G.H5 R 347 G.H5.12
Polar TM3 I 143 3x54 G.H5 Q 351 G.H5.16
Hydrophobic TM3 I 143 3x54 G.H5 Q 351 G.H5.16
Van-der-waals TM3 I 143 3x54 G.H5 Q 351 G.H5.16
Polar ICL2 L 147 34x51 G.S1 H 34 G.S1.02
Hydrophobic ICL2 L 147 34x51 G.S1 H 34 G.S1.02
Van-der-waals ICL2 L 147 34x51 G.S1 H 34 G.S1.02
Polar H8 K 375 8x48 G.H5 E 359 G.H5.24
Polar TM3 A 142 3x53 G.H5 H 354 G.H5.19
Hydrophobic TM3 A 142 3x53 G.H5 H 354 G.H5.19
Van-der-waals TM3 A 142 3x53 G.H5 H 354 G.H5.19
Polar TM6 N 304 6x26 G.H5 R 352 G.H5.17
Ionic TM5 E 235 5x64 G.H5 R 347 G.H5.12
Polar TM5 E 235 5x64 G.H5 R 347 G.H5.12
Hydrophobic TM5 E 235 5x64 G.H5 R 347 G.H5.12
Van-der-waals TM5 E 235 5x64 G.H5 R 347 G.H5.12
Hydrophobic TM3 I 143 3x54 G.H5 Y 358 G.H5.23
Polar TM2 T 76 2x39 G.H5 Y 358 G.H5.23
Hydrophobic TM2 T 76 2x39 G.H5 Y 358 G.H5.23
Aromatic ICL2 R 150 34x54 G.S1 H 34 G.S1.02
Hydrophobic ICL2 R 150 34x54 G.S1 H 34 G.S1.02
Hydrophobic H8 K 375 8x48 G.H5 L 361 G.H5.26
Van-der-waals H8 K 375 8x48 G.H5 L 361 G.H5.26
Polar TM5 E 235 5x64 G.H5 Q 351 G.H5.16
Van-der-waals TM5 E 235 5x64 G.H5 Q 351 G.H5.16
Hydrophobic ICL2 L 147 34x51 G.H5 I 350 G.H5.15
Hydrophobic ICL2 L 147 34x51 G.H5 C 346 G.H5.11
Polar TM7 M 373 7x56 G.H5 L 361 G.H5.26
Van-der-waals TM7 M 373 7x56 G.H5 L 361 G.H5.26
Polar TM2 T 76 2x39 G.H5 Q 357 G.H5.22
Hydrophobic ICL2 L 147 34x51 G.S3 V 194 G.S3.01
Polar ICL2 V 151 34x55 G.HN Q 28 G.HN.52
Hydrophobic ICL2 V 151 34x55 G.HN Q 28 G.HN.52
Hydrophobic TM6 V 311 6x33 G.H5 Y 358 G.H5.23
Hydrophobic TM3 A 142 3x53 G.H5 Y 358 G.H5.23
Polar TM3 C 144 3x55 G.H5 R 347 G.H5.12
Hydrophobic ICL2 L 147 34x51 G.H5 R 347 G.H5.12
Polar H8 N 374 8x47 G.H5 Q 357 G.H5.22
Polar H8 R 376 8x49 G.H5 R 356 G.H5.21
Hydrophobic H8 R 376 8x49 G.H5 R 356 G.H5.21
Van-der-waals H8 R 376 8x49 G.H5 R 356 G.H5.21
Hydrophobic TM6 V 311 6x33 G.H5 E 359 G.H5.24
Polar ICL2 R 150 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 R 150 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 150 34x54 G.hns1 R 31 G.hns1.02
Polar TM6 R 310 6x32 G.H5 L 360 G.H5.25
Hydrophobic TM6 R 310 6x32 G.H5 L 360 G.H5.25
Van-der-waals TM6 R 310 6x32 G.H5 L 360 G.H5.25
Hydrophobic TM3 I 143 3x54 G.H5 H 354 G.H5.19
Hydrophobic TM7 M 373 7x56 G.H5 L 360 G.H5.25
Van-der-waals TM7 M 373 7x56 G.H5 L 360 G.H5.25
Hydrophobic TM6 K 308 6x30 G.H5 L 355 G.H5.20
Hydrophobic TM6 V 311 6x33 G.H5 L 355 G.H5.20
Hydrophobic ICL2 Q 148 34x52 G.S3 V 194 G.S3.01
Polar TM6 N 304 6x26 G.H5 E 359 G.H5.24