OR5V1 - Gs

GPCR CLASS (FAMILY)

Class O2 (Olfactory/extra-nasal 2)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.7 Å

REFERENCE

PUBLICATION DATE

Jan. 21, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

PL45 - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic ICL2 P 129 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 129 - G.H5 I 350 G.H5.15
Hydrophobic ICL2 P 129 - G.H5 R 347 G.H5.12
Hydrophobic ICL3 I 228 - G.H5 L 355 G.H5.20
Van-der-waals ICL3 I 228 - G.H5 L 355 G.H5.20
Polar ICL2 C 127 - G.H5 Q 351 G.H5.16
Hydrophobic TM6 A 237 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 A 237 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM6 C 241 6x37 G.H5 L 360 G.H5.25
Hydrophobic TM3 A 125 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 A 125 3x53 G.H5 Y 358 G.H5.23
Polar ICL2 Y 132 - G.H5 Y 358 G.H5.23
Van-der-waals ICL2 Y 132 - G.H5 Y 358 G.H5.23
Hydrophobic TM3 I 126 3x54 G.H5 L 360 G.H5.25
Hydrophobic TM3 I 126 3x54 G.H5 H 354 G.H5.19
Van-der-waals TM3 I 126 3x54 G.H5 H 354 G.H5.19
Hydrophobic TM3 I 126 3x54 G.H5 Y 358 G.H5.23
Polar TM3 A 125 3x53 G.H5 H 354 G.H5.19
Van-der-waals TM3 A 125 3x53 G.H5 H 354 G.H5.19
Hydrophobic TM5 T 224 5x64 G.H5 Q 351 G.H5.16
Hydrophobic ICL2 P 129 - G.H5 H 354 G.H5.19
Van-der-waals ICL2 P 129 - G.H5 H 354 G.H5.19
Hydrophobic ICL2 L 130 - G.H5 R 347 G.H5.12
Hydrophobic ICL2 Y 132 - G.H5 H 354 G.H5.19
Van-der-waals ICL2 Y 132 - G.H5 H 354 G.H5.19
Hydrophobic TM5 I 225 5x65 G.H5 L 355 G.H5.20
Hydrophobic TM3 I 126 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 I 126 3x54 G.H5 L 355 G.H5.20
Polar TM6 T 240 6x36 G.H5 E 359 G.H5.24
Hydrophobic ICL2 P 129 - G.H5 Q 351 G.H5.16
Van-der-waals ICL2 P 129 - G.H5 Q 351 G.H5.16
Ionic TM6 K 236 6x32 G.H5 E 359 G.H5.24
Polar TM6 K 236 6x32 G.H5 E 359 G.H5.24
Van-der-waals TM6 K 236 6x32 G.H5 E 359 G.H5.24
Hydrophobic ICL2 L 130 - G.S3 V 194 G.S3.01
Van-der-waals ICL2 L 130 - G.S3 V 194 G.S3.01
Hydrophobic TM5 I 221 5x61 G.H5 L 360 G.H5.25
Aromatic TM3 R 122 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 122 3x50 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 L 130 - G.H5 I 350 G.H5.15
Hydrophobic ICL2 L 130 - G.H5 F 343 G.H5.08
Van-der-waals ICL2 L 130 - G.H5 F 343 G.H5.08