Refined structure (7DB6) of Gi1 - MT1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 219 from structure (61.9%), 135 from model (38.1%)
Residue sidechains - 219 from structure (61.9%), 135 from model (38.1%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 275 from structure (84.6%), 50 from model (15.4%)
Residue sidechains - 275 from structure (84.6%), 50 from model (15.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 Q - AF2 AF2
N-term 3 G - AF2 AF2
N-term 4 N - AF2 AF2
N-term 5 G - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 A - AF2 AF2
N-term 8 L - AF2 AF2
N-term 9 P - AF2 AF2
N-term 10 N - AF2 AF2
N-term 11 A - AF2 AF2
N-term 12 S - AF2 AF2
N-term 13 Q - AF2 AF2
N-term 14 P - AF2 AF2
N-term 15 V - AF2 AF2
N-term 16 L - AF2 AF2
N-term 17 R - AF2 AF2
N-term 18 G - AF2 AF2
N-term 19 D - AF2 AF2
N-term 20 G - AF2 AF2
N-term 21 A - AF2 AF2
N-term 22 R - AF2 AF2
TM1 23 P 1.28x28 Structure Structure
TM1 24 S 1.29x29 Structure Structure
TM1 25 W 1.30x30 Structure Structure
TM1 26 L 1.31x31 Structure Structure
TM1 27 A 1.32x32 Structure Structure
TM1 28 S 1.33x33 Structure Structure
TM1 29 A 1.34x34 Structure Structure
TM1 30 L 1.35x35 Structure Structure
TM1 31 A 1.36x36 Structure Structure
TM1 32 C 1.37x37 Structure Structure
TM1 33 V 1.38x38 Structure Structure
TM1 34 L 1.39x39 Structure Structure
TM1 35 I 1.40x40 Structure Structure
TM1 36 F 1.41x41 Structure Structure
TM1 37 T 1.42x42 Structure Structure
TM1 38 I 1.43x43 Structure Structure
TM1 39 V 1.44x44 Structure Structure
TM1 40 V 1.45x45 Structure Structure
TM1 41 D 1.46x46 Structure Structure
TM1 42 I 1.47x47 Structure Structure
TM1 43 L 1.48x48 Structure Structure
TM1 44 G 1.49x49 Structure Structure
TM1 45 N 1.50x50 Structure Structure
TM1 46 L 1.51x51 Structure Structure
TM1 47 L 1.52x52 Structure Structure
TM1 48 V 1.53x53 Structure Structure
TM1 49 I 1.54x54 Structure Structure
TM1 50 L 1.55x55 Structure Structure
TM1 51 S 1.56x56 Structure Structure
TM1 52 V 1.57x57 Structure Structure
TM1 53 Y 1.58x58 Structure Structure
TM1 54 R 1.59x59 Structure Structure
TM1 55 N 1.60x60 Structure Structure
ICL1 56 K 12.48x48 Structure Structure
ICL1 57 K 12.49x49 Structure Structure
ICL1 58 L 12.50x50 Structure Structure
ICL1 59 R 12.51x51 Structure Structure
TM2 60 N 2.37x37 Structure Structure
TM2 61 A 2.38x38 Structure Structure
TM2 62 G 2.39x39 Structure Structure
TM2 63 N 2.40x40 Structure Structure
TM2 64 I 2.41x41 Structure Structure
TM2 65 F 2.42x42 Structure Structure
TM2 66 V 2.43x43 Structure Structure
TM2 67 V 2.44x44 Structure Structure
TM2 68 S 2.45x45 Structure Structure
TM2 69 L 2.46x46 Structure Structure
TM2 70 A 2.47x47 Structure Structure
TM2 71 V 2.48x48 Structure Structure
TM2 72 A 2.49x49 Structure Structure
TM2 73 D 2.50x50 Structure Structure
TM2 74 L 2.51x51 Structure Structure
TM2 75 V 2.52x52 Structure Structure
TM2 76 V 2.53x53 Structure Structure
TM2 77 A 2.54x54 Structure Structure
TM2 78 I 2.55x55 Structure Structure
TM2 79 Y 2.56x551 Structure Structure
TM2 80 P 2.57x56 Structure Structure
TM2 81 Y 2.58x57 Structure Structure
TM2 82 P 2.59x58 Structure Structure
TM2 83 L 2.60x59 Structure Structure
TM2 84 V 2.61x60 Structure Structure
TM2 85 L 2.62x61 Structure Structure
TM2 86 M 2.63x62 Structure Structure
TM2 87 S 2.64x63 Structure Structure
TM2 88 I 2.65x64 Structure Structure
TM2 89 F 2.66x65 Structure Structure
TM2 90 N 2.67x66 Structure Structure
TM2 91 N 2.68x67 Structure Structure
ECL1 92 G 23.49x49 Structure Structure
ECL1 93 W 23.50x50 Structure Structure
ECL1 94 N 23.51x51 Structure Structure
ECL1 95 L 23.52x52 Structure Structure
TM3 96 G 3.21x21 Structure Structure
TM3 97 Y 3.22x22 Structure Structure
TM3 98 L 3.23x23 Structure Structure
TM3 99 H 3.24x24 Structure Structure
TM3 100 C 3.25x25 Structure Structure
TM3 101 Q 3.26x26 Structure Structure
TM3 102 V 3.27x27 Structure Structure
TM3 103 S 3.28x28 Structure Structure
TM3 104 G 3.29x29 Structure Structure
TM3 105 F 3.30x30 Structure Structure
TM3 106 L 3.31x31 Structure Structure
TM3 107 M 3.32x32 Structure Structure
TM3 108 G 3.33x33 Structure Structure
TM3 109 L 3.34x34 Structure Structure
TM3 110 S 3.35x35 Structure Structure
TM3 111 V 3.36x36 Structure Structure
TM3 112 I 3.37x37 Structure Structure
TM3 113 G 3.38x38 Structure Structure
TM3 114 S 3.39x39 Structure Structure
TM3 115 I 3.40x40 Structure Structure
TM3 116 F 3.41x41 Structure Structure
TM3 117 N 3.42x42 Structure Structure
TM3 118 I 3.43x43 Structure Structure
TM3 119 T 3.44x44 Structure Structure
TM3 120 G 3.45x45 Structure Structure
TM3 121 I 3.46x46 Structure Structure
TM3 122 A 3.47x47 Structure Structure
TM3 123 I 3.48x48 Structure Structure
TM3 124 N 3.49x49 Structure Structure
TM3 125 R 3.50x50 Structure Structure
TM3 126 Y 3.51x51 Structure Structure
TM3 127 C 3.52x52 Structure Structure
TM3 128 Y 3.53x53 Structure Structure
TM3 129 I 3.54x54 Structure Structure
TM3 130 C 3.55x55 Structure Structure
TM3 131 H 3.56x56 Structure Structure
ICL2 132 S 34.50x50 Structure Structure
ICL2 133 L 34.51x51 Structure Structure
ICL2 134 K 34.52x52 Structure Structure
ICL2 135 Y 34.53x53 Structure Structure
ICL2 136 D 34.54x54 Structure Structure
ICL2 137 K 34.55x55 Structure Structure
ICL2 138 L 34.56x56 Structure Structure
ICL2 139 Y 34.57x57 Structure Structure
TM4 140 S 4.38x38 Structure Structure
TM4 141 S 4.39x39 Structure Structure
TM4 142 K 4.40x40 Structure Structure
TM4 143 N 4.41x41 Structure Structure
TM4 144 S 4.42x42 Structure Structure
TM4 145 L 4.43x43 Structure Structure
TM4 146 C 4.44x44 Structure Structure
TM4 147 Y 4.45x45 Structure Structure
TM4 148 V 4.46x46 Structure Structure
TM4 149 L 4.47x47 Structure Structure
TM4 150 L 4.48x48 Structure Structure
TM4 151 I 4.49x49 Structure Structure
TM4 152 W 4.50x50 Structure Structure
TM4 153 L 4.51x51 Structure Structure
TM4 154 L 4.52x52 Structure Structure
TM4 155 T 4.53x53 Structure Structure
TM4 156 L 4.54x54 Structure Structure
TM4 157 A 4.55x55 Structure Structure
TM4 158 A 4.56x56 Structure Structure
TM4 159 V 4.57x57 Structure Structure
TM4 160 L 4.58x59 Structure Structure
TM4 161 P 4.59x60 Structure Structure
TM4 162 N 4.60x61 Structure Structure
TM4 163 L 4.61x62 Structure Structure
TM4 164 R 4.62x63 Structure Structure
TM4 165 A 4.63x64 Structure Structure
TM4 166 G 4.64x65 Structure Structure
ECL2 167 T - Structure Structure
ECL2 168 L - Structure Structure
ECL2 169 Q - Structure Structure
ECL2 170 Y - Structure Structure
ECL2 171 D - Structure Structure
ECL2 172 P - Structure Structure
ECL2 173 R - Structure Structure
ECL2 174 I - Structure Structure
ECL2 175 Y - Structure Structure
ECL2 176 S - Structure Structure
ECL2 177 C 45.50x50 Structure Structure
ECL2 178 T 45.51x51 Structure Structure
ECL2 179 F 45.52x52 Structure Structure
ECL2 180 A - Structure Structure
ECL2 181 Q - Structure Structure
ECL2 182 S - Structure Structure
ECL2 183 V - Structure Structure
TM5 184 S 5.35x36 Structure Structure
TM5 185 S 5.36x37 Structure Structure
TM5 186 A 5.37x38 Structure Structure
TM5 187 Y 5.38x39 Structure Structure
TM5 188 T 5.39x40 Structure Structure
TM5 189 I 5.40x41 Structure Structure
TM5 190 A 5.41x42 Structure Structure
TM5 191 V 5.42x43 Structure Structure
TM5 192 V 5.43x44 Structure Structure
TM5 193 V 5.44x45 Structure Structure
TM5 194 F 5.45x46 Structure Structure
TM5 195 H 5.46x461 Structure Structure
TM5 196 F 5.47x47 Structure Structure
TM5 197 L 5.48x48 Structure Structure
TM5 198 V 5.49x49 Structure Structure
TM5 199 P 5.50x50 Structure Structure
TM5 200 M 5.51x51 Structure Structure
TM5 201 I 5.52x52 Structure Structure
TM5 202 I 5.53x53 Structure Structure
TM5 203 V 5.54x54 Structure Structure
TM5 204 I 5.55x55 Structure Structure
TM5 205 F 5.56x56 Structure Structure
TM5 206 C 5.57x57 Structure Structure
TM5 207 Y 5.58x58 Structure Structure
TM5 208 L 5.59x59 Structure Structure
TM5 209 R 5.60x60 Structure Structure
TM5 210 I 5.61x61 Structure Structure
TM5 211 W 5.62x62 Structure Structure
TM5 212 I 5.63x63 Structure Structure
TM5 213 L 5.64x64 Structure Structure
TM5 214 V 5.65x65 Structure Structure
TM5 215 L 5.66x66 Structure Structure
TM5 216 Q 5.67x67 Structure Structure
TM5 217 V 5.68x68 Structure Structure
TM5 218 R 5.69x69 Structure Structure
TM5 219 Q 5.70x70 Structure Structure
TM5 220 R 5.71x71 Structure Structure
TM5 221 V 5.72x72 Structure Structure
ICL3 222 K - AF2 AF2
ICL3 223 P - AF2 AF2
ICL3 224 D - AF2 AF2
ICL3 225 R - AF2 AF2
ICL3 226 K - AF2 AF2
TM6 227 P 6.24x24 AF2 AF2
TM6 228 K 6.25x25 AF2 AF2
TM6 229 L 6.26x26 AF2 AF2
TM6 230 K 6.27x27 AF2 AF2
TM6 231 P 6.28x28 Structure Structure
TM6 232 Q 6.29x29 Structure Structure
TM6 233 D 6.30x30 Structure Structure
TM6 234 F 6.31x31 Structure Structure
TM6 235 R 6.32x32 Structure Structure
TM6 236 N 6.33x33 Structure Structure
TM6 237 F 6.34x34 Structure Structure
TM6 238 V 6.35x35 Structure Structure
TM6 239 T 6.36x36 Structure Structure
TM6 240 M 6.37x37 Structure Structure
TM6 241 F 6.38x38 Structure Structure
TM6 242 V 6.39x39 Structure Structure
TM6 243 V 6.40x40 Structure Structure
TM6 244 F 6.41x41 Structure Structure
TM6 245 V 6.42x42 Structure Structure
TM6 246 L 6.43x43 Structure Structure
TM6 247 F 6.44x44 Structure Structure
TM6 248 A 6.45x45 Structure Structure
TM6 249 I 6.46x46 Structure Structure
TM6 250 C 6.47x47 Structure Structure
TM6 251 W 6.48x48 Structure Structure
TM6 252 A 6.49x49 Structure Structure
TM6 253 P 6.50x50 Structure Structure
TM6 254 L 6.51x51 Structure Structure
TM6 255 N 6.52x52 Structure Structure
TM6 256 F 6.53x53 Structure Structure
TM6 257 I 6.54x54 Structure Structure
TM6 258 G 6.55x55 Structure Structure
TM6 259 L 6.56x56 Structure Structure
TM6 260 A 6.57x57 Structure Structure
TM6 261 V 6.58x58 Structure Structure
TM6 262 A 6.59x59 Structure Structure
TM6 263 S 6.60x60 Structure Structure
TM6 264 D 6.61x61 Structure Structure
ECL3 265 P - Structure Structure
ECL3 266 A - Structure Structure
ECL3 267 S - Structure Structure
ECL3 268 M - Structure Structure
ECL3 269 V - Structure Structure
ECL3 270 P - Structure Structure
ECL3 271 R - Structure Structure
ECL3 272 I - Structure Structure
TM7 273 P 7.31x30 Structure Structure
TM7 274 E 7.32x31 Structure Structure
TM7 275 W 7.33x32 Structure Structure
TM7 276 L 7.34x33 Structure Structure
TM7 277 F 7.35x34 Structure Structure
TM7 278 V 7.36x35 Structure Structure
TM7 279 A 7.37x36 Structure Structure
TM7 280 S 7.38x37 Structure Structure
TM7 281 Y 7.39x38 Structure Structure
TM7 282 Y 7.40x39 Structure Structure
TM7 283 M 7.41x40 Structure Structure
TM7 284 A 7.42x41 Structure Structure
TM7 285 Y 7.43x42 Structure Structure
TM7 286 F 7.44x43 Structure Structure
TM7 287 N 7.45x45 Structure Structure
TM7 288 S 7.46x46 Structure Structure
TM7 289 C 7.47x47 Structure Structure
TM7 290 L 7.48x48 Structure Structure
TM7 291 N 7.49x49 Structure Structure
TM7 292 A 7.50x50 Structure Structure
TM7 293 I 7.51x51 Structure Structure
TM7 294 I 7.52x52 Structure Structure
TM7 295 Y 7.53x53 Structure Structure
TM7 296 G 7.54x54 Structure Structure
TM7 297 L 7.55x55 Structure Structure
TM7 298 L 7.56x56 Structure Structure
H8 299 N 8.47x47 Structure Structure
H8 300 Q 8.48x48 Structure Structure
H8 301 N 8.49x49 Structure Structure
H8 302 F 8.50x50 Structure Structure
H8 303 R 8.51x51 Structure Structure
H8 304 K 8.52x52 Structure Structure
H8 305 E 8.53x53 Structure Structure
H8 306 Y 8.54x54 Structure Structure
H8 307 R 8.55x55 AF2 AF2
H8 308 R 8.56x56 AF2 AF2
H8 309 I 8.57x57 AF2 AF2
H8 310 I 8.58x58 AF2 AF2
H8 311 V 8.59x59 AF2 AF2
H8 312 S 8.60x60 AF2 AF2
H8 313 L 8.61x61 AF2 AF2
H8 314 C 8.62x62 AF2 AF2
H8 315 T 8.63x63 AF2 AF2
C-term 316 A - AF2 AF2
C-term 317 R - AF2 AF2
C-term 318 V - AF2 AF2
C-term 319 F - AF2 AF2
C-term 320 F - AF2 AF2
C-term 321 V - AF2 AF2
C-term 322 D - AF2 AF2
C-term 323 S - AF2 AF2
C-term 324 S - AF2 AF2
C-term 325 N - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 Y 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 W 211 5x62 G.H5 F 354 G.H5.26
Van-der-waals TM5 W 211 5x62 G.H5 F 354 G.H5.26
Hydrophobic H8 N 299 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 299 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 Y 128 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 128 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 210 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 221 5x72 G.H5 A 338 G.H5.10
Hydrophobic TM3 I 129 3x54 G.H5 C 351 G.H5.23
Ionic ICL2 D 136 34x54 G.hns1 R 32 G.hns1.03
Polar ICL2 D 136 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 136 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 129 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 129 3x54 G.H5 N 347 G.H5.19
Polar TM3 R 125 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 125 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 N 236 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 N 236 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 235 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM5 V 214 5x65 G.H5 I 344 G.H5.16
Van-der-waals ICL2 Y 135 34x53 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 V 221 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM3 I 129 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 129 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 I 210 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM5 I 210 5x61 G.H5 F 354 G.H5.26
Hydrophobic TM5 L 213 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 221 5x72 G.H5 D 341 G.H5.13
Hydrophobic H8 Q 300 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 Q 300 8x48 G.H5 G 352 G.H5.24
Polar H8 Q 300 8x48 G.H5 K 349 G.H5.21
Van-der-waals H8 Q 300 8x48 G.H5 K 349 G.H5.21
Polar ICL2 S 132 34x50 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 S 132 34x50 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 S 132 34x50 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 V 221 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 V 221 5x72 G.S6 Y 320 G.S6.02
Polar TM6 T 239 6x36 G.H5 F 354 G.H5.26
Hydrophobic TM6 T 239 6x36 G.H5 F 354 G.H5.26
Van-der-waals TM6 T 239 6x36 G.H5 F 354 G.H5.26
Hydrophobic TM5 Y 207 5x58 G.H5 L 353 G.H5.25
Van-der-waals TM5 Y 207 5x58 G.H5 L 353 G.H5.25
Polar ICL2 S 132 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 D 136 34x54 G.HN E 28 G.HN.52
Polar TM6 R 235 6x32 G.H5 L 353 G.H5.25
Ionic TM5 R 220 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 220 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 V 214 5x65 G.H5 F 354 G.H5.26
Polar TM3 Y 128 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 Y 128 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 125 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 217 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 214 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 214 5x65 G.H5 L 348 G.H5.20
Polar TM6 T 239 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 239 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 129 3x54 G.H5 I 344 G.H5.16