NTS1 receptor - G11

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.9 Å

REFERENCE

PUBLICATION DATE

March 25, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

NTS8–13 - Agonist pubchem

PHYSIOLOGICAL LIGANDS

large neuromedin N (Mouse), neurotensin (Human), neuromedin N (Human), large neuromedin N (Human), large neuromedin N (Rat), large neurotensin (Human), neuromedin N (Mouse)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic TM7 L 363 7x52 G.H5 L 358 G.H5.25
Van-der-waals TM7 L 363 7x52 G.H5 L 358 G.H5.25
Hydrophobic ICL2 F 174 34x51 G.S3 I 199 G.S3.01
Hydrophobic TM3 A 169 3x53 G.H5 E 355 G.H5.22
Hydrophobic ICL2 F 174 34x51 G.s2s3 E 197 G.s2s3.01
Van-der-waals ICL2 F 174 34x51 G.s2s3 E 197 G.s2s3.01
Hydrophobic ICL2 T 178 34x55 G.hns1 R 38 G.hns1.03
Polar H8 S 368 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 S 368 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 S 368 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM7 V 367 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 V 367 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM7 V 367 7x56 G.H5 L 358 G.H5.25
Van-der-waals TM7 V 367 7x56 G.H5 L 358 G.H5.25
Hydrophobic TM6 V 304 6x36 G.H5 L 358 G.H5.25
Van-der-waals TM6 V 304 6x36 G.H5 L 358 G.H5.25
Polar TM6 G 301 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM6 G 301 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 G 301 6x33 G.H5 V 359 G.H5.26