Refined structure (7EW1) of Gi1 - S1P5 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 227 from structure (64.1%), 127 from model (35.9%)
Residue sidechains - 227 from structure (64.1%), 127 from model (35.9%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 Structure Structure
G.H1 57 H G.H1.12 Structure Structure
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure Structure
G.s4h3 237 D G.s4h3.11 Structure Structure
G.s4h3 238 E G.s4h3.12 Structure Structure
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 269 from structure (81.0%), 63 from model (19.0%)
Residue sidechains - 268 from structure (80.7%), 64 from model (19.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 S - AF2 AF2
N-term 4 G - AF2 AF2
N-term 5 L - AF2 AF2
N-term 6 L - AF2 AF2
N-term 7 R - AF2 AF2
N-term 8 P - AF2 AF2
N-term 9 A - AF2 AF2
N-term 10 P - AF2 AF2
N-term 11 V - AF2 AF2
N-term 12 S - AF2 AF2
N-term 13 E - AF2 AF2
N-term 14 V - Structure Structure
N-term 15 I - Structure Structure
N-term 16 V - Structure Structure
N-term 17 L - Structure Structure
N-term 18 H - Structure Structure
N-term 19 Y - Structure Structure
N-term 20 N - Structure Structure
N-term 21 Y - Structure Structure
N-term 22 T - Structure Structure
N-term 23 G - Structure Structure
N-term 24 K - Structure Structure
N-term 25 L - Structure Structure
N-term 26 R - Structure Structure
N-term 27 G - Structure Structure
N-term 28 A - AF2 AF2
N-term 29 R - AF2 AF2
N-term 30 Y - AF2 AF2
N-term 31 Q - AF2 AF2
N-term 32 P - AF2 AF2
N-term 33 G - AF2 AF2
N-term 34 A - AF2 AF2
N-term 35 G - AF2 AF2
N-term 36 L - AF2 AF2
TM1 37 R 1.33x33 Structure Structure
TM1 38 A 1.34x34 Structure Structure
TM1 39 D 1.35x35 Structure Structure
TM1 40 A 1.36x36 Structure Structure
TM1 41 V 1.37x37 Structure Structure
TM1 42 V 1.38x38 Structure Structure
TM1 43 C 1.39x39 Structure Structure
TM1 44 L 1.40x40 Structure Structure
TM1 45 A 1.41x41 Structure Structure
TM1 46 V 1.42x42 Structure Structure
TM1 47 C 1.43x43 Structure Structure
TM1 48 A 1.44x44 Structure Structure
TM1 49 F 1.45x45 Structure Structure
TM1 50 I 1.46x46 Structure Structure
TM1 51 V 1.47x47 Structure Structure
TM1 52 L 1.48x48 Structure Structure
TM1 53 E 1.49x49 Structure Structure
TM1 54 N 1.50x50 Structure Structure
TM1 55 L 1.51x51 Structure Structure
TM1 56 A 1.52x52 Structure Structure
TM1 57 V 1.53x53 Structure Structure
TM1 58 L 1.54x54 Structure Structure
TM1 59 L 1.55x55 Structure Structure
TM1 60 V 1.56x56 Structure Structure
TM1 61 L 1.57x57 Structure Structure
TM1 62 G 1.58x58 Structure Structure
TM1 63 R 1.59x59 Structure Structure
TM1 64 H 1.60x60 AF2 AF2
ICL1 65 P 12.48x48 AF2 AF2
ICL1 66 R 12.49x49 AF2 AF2
ICL1 67 F 12.50x50 AF2 AF2
ICL1 68 H 12.51x51 Structure Structure
TM2 69 A 2.37x37 Structure Structure
TM2 70 P 2.38x38 Structure Structure
TM2 71 M 2.39x39 Structure Structure
TM2 72 F 2.40x40 Structure Structure
TM2 73 L 2.41x41 Structure Structure
TM2 74 L 2.42x42 Structure Structure
TM2 75 L 2.43x43 Structure Structure
TM2 76 G 2.44x44 Structure Structure
TM2 77 S 2.45x45 Structure Structure
TM2 78 L 2.46x46 Structure Structure
TM2 79 T 2.47x47 Structure Structure
TM2 80 L 2.48x48 Structure Structure
TM2 81 S 2.49x49 Structure Structure
TM2 82 D 2.50x50 Structure Structure
TM2 83 L 2.51x51 Structure Structure
TM2 84 L 2.52x52 Structure Structure
TM2 85 A 2.53x53 Structure Structure
TM2 86 G 2.54x54 Structure Structure
TM2 87 A 2.55x55 Structure Structure
TM2 88 A 2.56x56 Structure Structure
TM2 89 Y 2.57x57 Structure Structure
TM2 90 A 2.58x58 Structure Structure
TM2 91 A 2.59x59 Structure Structure
TM2 92 N 2.60x60 Structure Structure
TM2 93 I 2.61x61 Structure Structure
TM2 94 L 2.62x62 Structure Structure
TM2 95 L 2.63x63 Structure Structure
TM2 96 S 2.64x64 Structure Structure
ECL1 97 G 23.47x47 Structure Structure
ECL1 98 P 23.48x48 Structure Structure
ECL1 99 L 23.49x49 Structure Structure
ECL1 100 T 23.50x50 Structure Structure
ECL1 101 L 23.51x501 Structure Structure
ECL1 102 K 23.52x51 Structure Structure
ECL1 103 L 23.53x52 Structure Structure
TM3 104 S 3.21x21 Structure Structure
TM3 105 P 3.22x22 Structure Structure
TM3 106 A 3.23x23 Structure Structure
TM3 107 L 3.24x24 Structure Structure
TM3 108 W 3.25x25 Structure Structure
TM3 109 F 3.26x26 Structure Structure
TM3 110 A 3.27x27 Structure Structure
TM3 111 R 3.28x28 Structure Structure
TM3 112 E 3.29x29 Structure Structure
TM3 113 G 3.30x30 Structure Structure
TM3 114 G 3.31x31 Structure Structure
TM3 115 V 3.32x32 Structure Structure
TM3 116 F 3.33x33 Structure Structure
TM3 117 V 3.34x34 Structure Structure
TM3 118 A 3.35x35 Structure Structure
TM3 119 L 3.36x36 Structure Structure
TM3 120 T 3.37x37 Structure Structure
TM3 121 A 3.38x38 Structure Structure
TM3 122 S 3.39x39 Structure Structure
TM3 123 V 3.40x40 Structure Structure
TM3 124 L 3.41x41 Structure Structure
TM3 125 S 3.42x42 Structure Structure
TM3 126 L 3.43x43 Structure Structure
TM3 127 L 3.44x44 Structure Structure
TM3 128 A 3.45x45 Structure Structure
TM3 129 I 3.46x46 Structure Structure
TM3 130 A 3.47x47 Structure Structure
TM3 131 L 3.48x48 Structure Structure
TM3 132 E 3.49x49 Structure Structure
TM3 133 R 3.50x50 Structure Structure
TM3 134 S 3.51x51 Structure Structure
TM3 135 L 3.52x52 Structure Structure
TM3 136 T 3.53x53 Structure Structure
TM3 137 M 3.54x54 Structure Structure
TM3 138 A 3.55x55 Structure Structure
TM3 139 R 3.56x56 Structure Structure
ICL2 140 R 34.50x50 Structure Structure
ICL2 141 G 34.51x51 Structure Structure
ICL2 142 P 34.52x52 Structure Structure
ICL2 143 A 34.53x53 Structure Structure
ICL2 144 P 34.54x54 Structure Structure
ICL2 145 V 34.55x55 Structure Structure
ICL2 146 S 34.56x56 Structure Structure
TM4 147 S 4.38x38 Structure Structure
TM4 148 R 4.39x39 Structure Structure
TM4 149 G 4.40x40 Structure Structure
TM4 150 R 4.41x41 Structure Structure
TM4 151 T 4.42x42 Structure Structure
TM4 152 L 4.43x43 Structure Structure
TM4 153 A 4.44x44 Structure Structure
TM4 154 M 4.45x45 Structure Structure
TM4 155 A 4.46x46 Structure Structure
TM4 156 A 4.47x47 Structure Structure
TM4 157 A 4.48x48 Structure Structure
TM4 158 A 4.49x49 Structure Structure
TM4 159 W 4.50x50 Structure Structure
TM4 160 G 4.51x51 Structure Structure
TM4 161 V 4.52x52 Structure Structure
TM4 162 S 4.53x53 Structure Structure
TM4 163 L 4.54x54 Structure Structure
TM4 164 L 4.55x55 Structure Structure
TM4 165 L 4.56x56 Structure Structure
TM4 166 G 4.57x57 Structure Structure
TM4 167 L 4.58x58 Structure Structure
TM4 168 L 4.59x59 Structure Structure
TM4 169 P 4.60x60 Structure Structure
TM4 170 A 4.61x61 Structure Structure
TM4 171 L 4.62x62 Structure Structure
TM4 172 G 4.63x63 Structure Structure
ECL2 173 W - Structure Structure
ECL2 174 N - Structure Structure
ECL2 175 C - Structure Structure
ECL2 176 L - Structure Structure
ECL2 177 G - Structure Structure
ECL2 178 R - Structure AF2
ECL2 179 L - Structure Structure
ECL2 180 D - Structure Structure
ECL2 181 A - Structure Structure
ECL2 182 C - Structure Structure
ECL2 183 S - Structure Structure
ECL2 184 T - Structure Structure
ECL2 185 V - Structure Structure
ECL2 186 L - Structure Structure
ECL2 187 P - Structure Structure
ECL2 188 L - Structure Structure
ECL2 189 Y - Structure Structure
TM5 190 A 5.36x36 Structure Structure
TM5 191 K 5.37x37 Structure Structure
TM5 192 A 5.38x38 Structure Structure
TM5 193 Y 5.39x39 Structure Structure
TM5 194 V 5.40x40 Structure Structure
TM5 195 L 5.41x41 Structure Structure
TM5 196 F 5.42x42 Structure Structure
TM5 197 C 5.43x43 Structure Structure
TM5 198 V 5.44x44 Structure Structure
TM5 199 L 5.45x45 Structure Structure
TM5 200 A 5.46x46 Structure Structure
TM5 201 F 5.47x47 Structure Structure
TM5 202 V 5.48x48 Structure Structure
TM5 203 G 5.49x49 Structure Structure
TM5 204 I 5.50x50 Structure Structure
TM5 205 L 5.51x51 Structure Structure
TM5 206 A 5.52x52 Structure Structure
TM5 207 A 5.53x53 Structure Structure
TM5 208 I 5.54x54 Structure Structure
TM5 209 C 5.55x55 Structure Structure
TM5 210 A 5.56x56 Structure Structure
TM5 211 L 5.57x57 Structure Structure
TM5 212 Y 5.58x58 Structure Structure
TM5 213 A 5.59x59 Structure Structure
TM5 214 R 5.60x60 Structure Structure
TM5 215 I 5.61x61 Structure Structure
TM5 216 Y 5.62x62 Structure Structure
TM5 217 C 5.63x63 Structure Structure
TM5 218 Q 5.64x64 Structure Structure
TM5 219 V 5.65x65 Structure Structure
TM5 220 R 5.66x66 Structure Structure
TM5 221 A 5.67x67 Structure Structure
TM5 222 N 5.68x68 Structure Structure
TM5 223 A 5.69x69 Structure Structure
TM5 224 R 5.70x70 Structure Structure
TM5 225 R 5.71x71 Structure Structure
TM5 226 L 5.72x72 Structure Structure
TM5 227 P 5.73x73 AF2 AF2
TM5 228 A 5.74x74 AF2 AF2
TM5 229 R 5.75x75 AF2 AF2
TM5 230 P 5.76x76 AF2 AF2
TM5 231 G 5.77x77 AF2 AF2
TM5 232 T 5.78x78 AF2 AF2
TM5 233 A 5.79x79 AF2 AF2
TM5 234 G 5.80x80 AF2 AF2
ICL3 235 T - AF2 AF2
ICL3 236 T - AF2 AF2
ICL3 237 S - AF2 AF2
ICL3 238 T - AF2 AF2
TM6 239 R 6.23x23 AF2 AF2
TM6 240 A 6.24x24 AF2 AF2
TM6 241 R 6.25x25 AF2 AF2
TM6 242 R 6.26x26 Structure Structure
TM6 243 K 6.27x27 Structure Structure
TM6 244 P 6.28x28 Structure Structure
TM6 245 R 6.29x29 Structure Structure
TM6 246 S 6.30x30 Structure Structure
TM6 247 L 6.31x31 Structure Structure
TM6 248 A 6.32x32 Structure Structure
TM6 249 L 6.33x33 Structure Structure
TM6 250 L 6.34x34 Structure Structure
TM6 251 R 6.35x35 Structure Structure
TM6 252 T 6.36x36 Structure Structure
TM6 253 L 6.37x37 Structure Structure
TM6 254 S 6.38x38 Structure Structure
TM6 255 V 6.39x39 Structure Structure
TM6 256 V 6.40x40 Structure Structure
TM6 257 L 6.41x41 Structure Structure
TM6 258 L 6.42x42 Structure Structure
TM6 259 A 6.43x43 Structure Structure
TM6 260 F 6.44x44 Structure Structure
TM6 261 V 6.45x45 Structure Structure
TM6 262 A 6.46x46 Structure Structure
TM6 263 C 6.47x47 Structure Structure
TM6 264 W 6.48x48 Structure Structure
TM6 265 G 6.49x49 Structure Structure
TM6 266 P 6.50x50 Structure Structure
TM6 267 L 6.51x51 Structure Structure
TM6 268 F 6.52x52 Structure Structure
TM6 269 L 6.53x53 Structure Structure
TM6 270 L 6.54x54 Structure Structure
TM6 271 L 6.55x55 Structure Structure
TM6 272 L 6.56x56 Structure Structure
TM6 273 L 6.57x57 Structure Structure
TM6 274 D 6.58x58 Structure Structure
TM6 275 V 6.59x59 Structure Structure
TM6 276 A 6.60x60 Structure Structure
TM6 277 C 6.61x61 Structure Structure
ECL3 278 P - Structure Structure
ECL3 279 A - Structure Structure
ECL3 280 R - Structure Structure
ECL3 281 T - Structure Structure
ECL3 282 C - Structure Structure
TM7 283 P 7.30x29 Structure Structure
TM7 284 V 7.31x30 Structure Structure
TM7 285 L 7.32x31 Structure Structure
TM7 286 L 7.33x32 Structure Structure
TM7 287 Q 7.34x33 Structure Structure
TM7 288 A 7.35x34 Structure Structure
TM7 289 D 7.36x35 Structure Structure
TM7 290 P 7.37x36 Structure Structure
TM7 291 F 7.38x37 Structure Structure
TM7 292 L 7.39x38 Structure Structure
TM7 293 G 7.40x39 Structure Structure
TM7 294 L 7.41x40 Structure Structure
TM7 295 A 7.42x41 Structure Structure
TM7 296 M 7.43x42 Structure Structure
TM7 297 A 7.44x43 Structure Structure
TM7 298 N 7.45x45 Structure Structure
TM7 299 S 7.46x46 Structure Structure
TM7 300 L 7.47x47 Structure Structure
TM7 301 L 7.48x48 Structure Structure
TM7 302 N 7.49x49 Structure Structure
TM7 303 P 7.50x50 Structure Structure
TM7 304 I 7.51x51 Structure Structure
TM7 305 I 7.52x52 Structure Structure
TM7 306 Y 7.53x53 Structure Structure
TM7 307 T 7.54x54 Structure Structure
TM7 308 L 7.55x55 Structure Structure
TM7 309 T 7.56x56 Structure Structure
H8 310 N 8.47x47 Structure Structure
H8 311 R 8.48x48 AF2 AF2
H8 312 D 8.49x49 AF2 AF2
H8 313 L 8.50x50 AF2 AF2
H8 314 R 8.51x51 AF2 AF2
H8 315 H 8.52x52 AF2 AF2
H8 316 A 8.53x53 AF2 AF2
H8 317 L 8.54x54 AF2 AF2
H8 318 L 8.55x55 AF2 AF2
H8 319 R 8.56x56 AF2 AF2
H8 320 L 8.57x57 AF2 AF2
H8 321 V 8.58x58 AF2 AF2
H8 322 C 8.59x59 AF2 AF2
C-term 323 C - AF2 AF2
C-term 324 G - AF2 AF2
C-term 325 R - AF2 AF2
C-term 326 H - AF2 AF2
C-term 327 S - AF2 AF2
C-term 328 C - AF2 AF2
C-term 329 G - AF2 AF2
C-term 330 R - AF2 AF2
C-term 331 D - AF2 AF2
C-term 332 P - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 M 137 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 M 137 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 140 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 R 140 34x50 G.H5 I 343 G.H5.15
Polar TM6 R 242 6x26 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM6 R 242 6x26 G.h4s6 K 317 G.h4s6.11
Van-der-waals TM6 R 242 6x26 G.h4s6 K 317 G.h4s6.11
Polar TM3 T 136 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 T 136 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 G 234 5x80 H.HD A 138 H.HD.05
Ionic TM6 R 239 6x23 G.H4 E 308 G.H4.16
Polar TM6 R 239 6x23 G.H4 E 308 G.H4.16
Hydrophobic TM6 R 239 6x23 G.H4 E 308 G.H4.16
Van-der-waals TM6 R 239 6x23 G.H4 E 308 G.H4.16
Ionic TM3 R 139 3x56 G.H5 D 350 G.H5.22
Polar TM3 R 139 3x56 G.H5 D 350 G.H5.22
Van-der-waals TM3 R 139 3x56 G.H5 D 350 G.H5.22
Hydrophobic TM5 L 226 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 L 226 5x72 G.H5 D 341 G.H5.13
Polar TM5 P 227 5x73 G.H5 D 337 G.H5.09
Hydrophobic TM5 P 227 5x73 G.H5 D 337 G.H5.09
Van-der-waals TM5 P 227 5x73 G.H5 D 337 G.H5.09
Polar TM3 R 139 3x56 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 139 3x56 G.H5 N 347 G.H5.19
Polar TM7 T 309 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 T 309 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 T 309 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM3 M 137 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM6 R 245 6x29 G.H5 F 354 G.H5.26
Polar ICL3 T 238 - H.HD R 144 H.HD.11
Hydrophobic ICL3 T 238 - H.HD R 144 H.HD.11
Van-der-waals ICL3 T 238 - H.HD R 144 H.HD.11
Hydrophobic TM3 T 136 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 T 136 3x53 G.H5 C 351 G.H5.23
Polar ICL3 S 237 - H.HD E 145 H.HD.12
Hydrophobic ICL3 S 237 - H.HD E 145 H.HD.12
Van-der-waals ICL3 S 237 - H.HD E 145 H.HD.12
Hydrophobic TM6 L 249 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 253 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 253 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 142 34x52 G.S1 E 33 G.S1.01
Van-der-waals ICL2 P 142 34x52 G.S1 E 33 G.S1.01
Ionic TM6 R 242 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 242 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 242 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 242 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 P 230 5x76 G.S6 F 323 G.S6.05
Hydrophobic TM5 A 233 5x79 H.HD N 141 H.HD.08
Van-der-waals TM5 A 233 5x79 H.HD N 141 H.HD.08
Hydrophobic TM6 R 239 6x23 H.HD R 144 H.HD.11
Van-der-waals TM6 R 239 6x23 H.HD R 144 H.HD.11
Polar TM6 T 252 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 252 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 252 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 245 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 245 6x29 G.H5 K 345 G.H5.17
Polar ICL3 S 237 - H.HD R 144 H.HD.11
Hydrophobic ICL3 S 237 - H.HD R 144 H.HD.11
Van-der-waals ICL3 S 237 - H.HD R 144 H.HD.11
Hydrophobic TM3 R 133 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM2 M 71 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 M 71 2x39 G.H5 C 351 G.H5.23
Aromatic TM5 R 229 5x75 G.S6 Y 320 G.S6.02
Hydrophobic TM5 R 229 5x75 G.S6 Y 320 G.S6.02
Van-der-waals TM5 R 229 5x75 G.S6 Y 320 G.S6.02
Hydrophobic TM5 L 226 5x72 G.H5 T 340 G.H5.12
Hydrophobic ICL2 P 142 34x52 G.S1 V 34 G.S1.02
Van-der-waals ICL2 P 142 34x52 G.S1 V 34 G.S1.02
Ionic ICL2 R 140 34x50 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 140 34x50 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 R 229 5x75 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 R 229 5x75 G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL2 P 142 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 N 222 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 N 222 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 T 232 5x78 H.HD F 140 H.HD.07
Polar TM5 T 232 5x78 H.HD N 141 H.HD.08
Hydrophobic TM5 T 232 5x78 H.HD N 141 H.HD.08
Van-der-waals TM5 T 232 5x78 H.HD N 141 H.HD.08
Hydrophobic TM6 L 249 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 249 6x33 G.H5 L 353 G.H5.25
Polar TM5 T 232 5x78 H.HD S 143 H.HD.10
Hydrophobic TM5 T 232 5x78 H.HD S 143 H.HD.10
Van-der-waals TM5 T 232 5x78 H.HD S 143 H.HD.10
Polar TM3 M 137 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 M 137 3x54 G.H5 N 347 G.H5.19
Polar ICL3 T 235 - H.HD R 142 H.HD.09
Hydrophobic ICL3 T 235 - H.HD R 142 H.HD.09
Van-der-waals ICL3 T 235 - H.HD R 142 H.HD.09
Polar ICL3 T 235 - H.HD A 138 H.HD.05
Hydrophobic ICL3 T 235 - H.HD A 138 H.HD.05
Van-der-waals ICL3 T 235 - H.HD A 138 H.HD.05
Hydrophobic TM6 R 245 6x29 G.H5 L 348 G.H5.20
Van-der-waals TM6 R 245 6x29 G.H5 L 348 G.H5.20
Ionic TM6 R 245 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 242 6x26 G.h4s6 T 316 G.h4s6.10
Hydrophobic TM6 R 242 6x26 G.h4s6 T 316 G.h4s6.10
Van-der-waals TM6 R 242 6x26 G.h4s6 T 316 G.h4s6.10
Polar TM3 R 133 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 C 351 G.H5.23
Polar TM5 R 229 5x75 G.S6 I 319 G.S6.01
Hydrophobic TM5 R 229 5x75 G.S6 I 319 G.S6.01
Van-der-waals TM5 R 229 5x75 G.S6 I 319 G.S6.01
Ionic TM6 R 245 6x29 G.H5 D 341 G.H5.13
Polar TM6 R 245 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 245 6x29 G.H5 D 341 G.H5.13
Hydrophobic TM5 L 226 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 L 226 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM7 T 309 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM5 G 234 5x80 H.HD N 141 H.HD.08
Van-der-waals TM5 G 234 5x80 H.HD N 141 H.HD.08
Polar TM6 R 242 6x26 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 R 140 34x50 G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 142 34x52 G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 142 34x52 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 142 34x52 G.hns1 R 32 G.hns1.03
Polar ICL3 T 235 - H.HD N 141 H.HD.08
Hydrophobic ICL3 T 235 - H.HD N 141 H.HD.08