Refined structure (8W8Q) of Gs - GPR101

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-07-12

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 232 from structure (58.9%), 162 from model (41.1%)
Residue sidechains - 216 from structure (54.8%), 178 from model (45.2%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 Structure Structure
G.HN 10 E G.HN.27 Structure Structure
G.HN 11 D G.HN.28 Structure Structure
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure Structure
G.s1h1 50 E G.s1h1.04 Structure AF2
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure AF2
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure AF2
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure AF2
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure AF2
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure Structure
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 AF2 AF2
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure AF2
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure AF2
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure AF2
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure AF2
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure AF2
G.h3s5 285 I G.h3s5.03 Structure AF2
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure Structure
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure AF2
G.HG 310 D G.HG.17 Structure AF2
G.hgh4 311 Y G.hgh4.01 Structure AF2
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure AF2
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 285 from structure (84.1%), 54 from model (15.9%)
Residue sidechains - 283 from structure (83.5%), 56 from model (16.5%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 T - AF2 AF2
N-term 3 S - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 C - AF2 AF2
N-term 6 T - AF2 AF2
N-term 7 N - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 T - AF2 AF2
N-term 10 R - AF2 AF2
N-term 11 E - AF2 AF2
N-term 12 S - AF2 AF2
N-term 13 N - AF2 AF2
N-term 14 S - AF2 AF2
N-term 15 S - AF2 AF2
N-term 16 H - AF2 AF2
N-term 17 T - AF2 AF2
N-term 18 C - AF2 AF2
N-term 19 M - AF2 AF2
N-term 20 P - AF2 AF2
N-term 21 L - AF2 AF2
N-term 22 S - AF2 AF2
N-term 23 K - AF2 AF2
N-term 24 M - AF2 AF2
N-term 25 P - AF2 AF2
N-term 26 I - AF2 AF2
TM1 27 S 1.28x28 Structure Structure
TM1 28 L 1.29x29 Structure Structure
TM1 29 A 1.30x30 Structure Structure
TM1 30 H 1.31x31 Structure Structure
TM1 31 G 1.32x32 Structure Structure
TM1 32 I 1.33x33 Structure Structure
TM1 33 I 1.34x34 Structure Structure
TM1 34 R 1.35x35 Structure Structure
TM1 35 S 1.36x36 Structure Structure
TM1 36 T 1.37x37 Structure Structure
TM1 37 V 1.38x38 Structure Structure
TM1 38 L 1.39x39 Structure Structure
TM1 39 V 1.40x40 Structure Structure
TM1 40 I 1.41x41 Structure Structure
TM1 41 F 1.42x42 Structure Structure
TM1 42 L 1.43x43 Structure Structure
TM1 43 A 1.44x44 Structure Structure
TM1 44 A 1.45x45 Structure Structure
TM1 45 S 1.46x46 Structure Structure
TM1 46 F 1.47x47 Structure Structure
TM1 47 V 1.48x48 Structure Structure
TM1 48 G 1.49x49 Structure Structure
TM1 49 N 1.50x50 Structure Structure
TM1 50 I 1.51x51 Structure Structure
TM1 51 V 1.52x52 Structure Structure
TM1 52 L 1.53x53 Structure Structure
TM1 53 A 1.54x54 Structure Structure
TM1 54 L 1.55x55 Structure Structure
TM1 55 V 1.56x56 Structure Structure
TM1 56 L 1.57x57 Structure Structure
TM1 57 Q 1.58x58 Structure Structure
TM1 58 R 1.59x59 Structure Structure
TM1 59 K 1.60x60 Structure Structure
ICL1 60 P 12.48x48 Structure Structure
ICL1 61 Q 12.49x49 Structure Structure
ICL1 62 L 12.50x50 Structure Structure
ICL1 63 L 12.51x51 Structure Structure
TM2 64 Q 2.37x37 Structure Structure
TM2 65 V 2.38x38 Structure Structure
TM2 66 T 2.39x39 Structure Structure
TM2 67 N 2.40x40 Structure Structure
TM2 68 R 2.41x41 Structure Structure
TM2 69 F 2.42x42 Structure Structure
TM2 70 I 2.43x43 Structure Structure
TM2 71 F 2.44x44 Structure Structure
TM2 72 N 2.45x45 Structure Structure
TM2 73 L 2.46x46 Structure Structure
TM2 74 L 2.47x47 Structure Structure
TM2 75 V 2.48x48 Structure Structure
TM2 76 T 2.49x49 Structure Structure
TM2 77 D 2.50x50 Structure Structure
TM2 78 L 2.51x51 Structure Structure
TM2 79 L 2.52x52 Structure Structure
TM2 80 Q 2.53x53 Structure Structure
TM2 81 I 2.54x54 Structure Structure
TM2 82 S 2.55x55 Structure Structure
TM2 83 L 2.56x551 Structure Structure
TM2 84 V 2.57x56 Structure Structure
TM2 85 A 2.58x57 Structure Structure
TM2 86 P 2.59x58 Structure Structure
TM2 87 W 2.60x59 Structure Structure
TM2 88 V 2.61x60 Structure Structure
TM2 89 V 2.62x61 Structure Structure
TM2 90 A 2.63x62 Structure Structure
TM2 91 T 2.64x63 Structure Structure
TM2 92 S 2.65x64 Structure Structure
TM2 93 V 2.66x65 Structure Structure
TM2 94 P 2.67x66 Structure Structure
ECL1 95 L - Structure Structure
ECL1 96 F 23.49x49 Structure Structure
ECL1 97 W 23.50x50 Structure Structure
ECL1 98 P 23.51x51 Structure Structure
ECL1 99 L 23.52x52 Structure Structure
TM3 100 N 3.21x21 Structure Structure
TM3 101 S 3.22x22 Structure Structure
TM3 102 H 3.23x23 Structure Structure
TM3 103 F 3.24x24 Structure Structure
TM3 104 C 3.25x25 Structure Structure
TM3 105 T 3.26x26 Structure Structure
TM3 106 A 3.27x27 Structure Structure
TM3 107 L 3.28x28 Structure Structure
TM3 108 V 3.29x29 Structure Structure
TM3 109 S 3.30x30 Structure Structure
TM3 110 L 3.31x31 Structure Structure
TM3 111 T 3.32x32 Structure Structure
TM3 112 H 3.33x33 Structure Structure
TM3 113 L 3.34x34 Structure Structure
TM3 114 F 3.35x35 Structure Structure
TM3 115 A 3.36x36 Structure Structure
TM3 116 F 3.37x37 Structure Structure
TM3 117 A 3.38x38 Structure Structure
TM3 118 S 3.39x39 Structure Structure
TM3 119 V 3.40x40 Structure Structure
TM3 120 N 3.41x41 Structure Structure
TM3 121 T 3.42x42 Structure Structure
TM3 122 I 3.43x43 Structure Structure
TM3 123 V 3.44x44 Structure Structure
TM3 124 V 3.45x45 Structure Structure
TM3 125 V 3.46x46 Structure Structure
TM3 126 S 3.47x47 Structure Structure
TM3 127 V 3.48x48 Structure Structure
TM3 128 D 3.49x49 Structure Structure
TM3 129 R 3.50x50 Structure Structure
TM3 130 Y 3.51x51 Structure Structure
TM3 131 L 3.52x52 Structure Structure
TM3 132 S 3.53x53 Structure Structure
TM3 133 I 3.54x54 Structure Structure
TM3 134 I 3.55x55 Structure Structure
TM3 135 H 3.56x56 Structure Structure
ICL2 136 P 34.50x50 Structure Structure
ICL2 137 L 34.51x51 Structure Structure
ICL2 138 S 34.52x52 Structure Structure
ICL2 139 Y 34.53x53 Structure Structure
ICL2 140 P 34.54x54 Structure Structure
ICL2 141 S 34.55x55 Structure Structure
ICL2 142 K 34.56x56 Structure Structure
ICL2 143 M 34.57x57 Structure Structure
TM4 144 T 4.38x38 Structure Structure
TM4 145 Q 4.39x39 Structure Structure
TM4 146 R 4.40x40 Structure Structure
TM4 147 R 4.41x41 Structure Structure
TM4 148 G 4.42x42 Structure Structure
TM4 149 Y 4.43x43 Structure Structure
TM4 150 L 4.44x44 Structure Structure
TM4 151 L 4.45x45 Structure Structure
TM4 152 L 4.46x46 Structure Structure
TM4 153 Y 4.47x47 Structure Structure
TM4 154 G 4.48x48 Structure Structure
TM4 155 T 4.49x49 Structure Structure
TM4 156 W 4.50x50 Structure Structure
TM4 157 I 4.51x51 Structure Structure
TM4 158 V 4.52x52 Structure Structure
TM4 159 A 4.53x53 Structure Structure
TM4 160 I 4.54x54 Structure Structure
TM4 161 L 4.55x55 Structure Structure
TM4 162 Q 4.56x56 Structure Structure
TM4 163 S 4.57x57 Structure Structure
TM4 164 T 4.58x58 Structure Structure
TM4 165 P 4.59x59 Structure Structure
TM4 166 P 4.60x60 Structure Structure
TM4 167 L 4.61x61 Structure Structure
TM4 168 Y 4.62x62 Structure Structure
TM4 169 G 4.63x63 Structure Structure
ECL2 170 W - Structure Structure
ECL2 171 G - Structure Structure
ECL2 172 Q - Structure Structure
ECL2 173 A - Structure Structure
ECL2 174 A - Structure Structure
ECL2 175 F - Structure Structure
ECL2 176 D - Structure Structure
ECL2 177 E - Structure Structure
ECL2 178 R - Structure Structure
ECL2 179 N - Structure Structure
ECL2 180 A - Structure Structure
ECL2 181 L - Structure Structure
ECL2 182 C 45.50x50 Structure Structure
ECL2 183 S 45.51x51 Structure Structure
ECL2 184 M 45.52x52 Structure Structure
ECL2 185 I - Structure Structure
ECL2 186 W - Structure Structure
ECL2 187 G - Structure Structure
ECL2 188 A - Structure Structure
TM5 189 S 5.35x36 Structure Structure
TM5 190 P 5.36x37 Structure Structure
TM5 191 S 5.37x38 Structure Structure
TM5 192 Y 5.38x39 Structure Structure
TM5 193 T 5.39x40 Structure Structure
TM5 194 I 5.40x41 Structure Structure
TM5 195 L 5.41x42 Structure Structure
TM5 196 S 5.42x43 Structure Structure
TM5 197 V 5.43x44 Structure Structure
TM5 198 V 5.44x45 Structure Structure
TM5 199 S 5.45x46 Structure Structure
TM5 200 F 5.46x461 Structure Structure
TM5 201 I 5.47x47 Structure Structure
TM5 202 V 5.48x48 Structure Structure
TM5 203 I 5.49x49 Structure Structure
TM5 204 P 5.50x50 Structure Structure
TM5 205 L 5.51x51 Structure Structure
TM5 206 I 5.52x52 Structure Structure
TM5 207 V 5.53x53 Structure Structure
TM5 208 M 5.54x54 Structure Structure
TM5 209 I 5.55x55 Structure Structure
TM5 210 A 5.56x56 Structure Structure
TM5 211 C 5.57x57 Structure Structure
TM5 212 Y 5.58x58 Structure Structure
TM5 213 S 5.59x59 Structure Structure
TM5 214 V 5.60x60 Structure Structure
TM5 215 V 5.61x61 Structure Structure
TM5 216 F 5.62x62 Structure Structure
TM5 217 C 5.63x63 Structure Structure
TM5 218 A 5.64x64 Structure Structure
TM5 219 A 5.65x65 Structure Structure
TM5 220 R 5.66x66 Structure Structure
TM5 221 R 5.67x67 Structure Structure
TM5 222 Q 5.68x68 Structure Structure
TM5 223 H 5.69x69 Structure Structure
TM5 224 A 5.70x70 Structure Structure
TM5 225 L 5.71x71 Structure Structure
TM5 226 L 5.72x72 Structure Structure
TM5 227 Y 5.73x73 Structure Structure
TM5 228 N 5.74x74 Structure Structure
TM5 229 V 5.75x75 AF2 AF2
ICL3 230 K - AF2 AF2
ICL3 231 R - AF2 AF2
ICL3 232 H - AF2 AF2
ICL3 233 S - AF2 AF2
ICL3 234 L - AF2 AF2
ICL3 235 E - AF2 AF2
ICL3 236 V - AF2 AF2
ICL3 381 R - AF2 AF2
ICL3 382 N - AF2 AF2
ICL3 383 S - AF2 AF2
ICL3 384 N - AF2 AF2
ICL3 385 S - AF2 AF2
ICL3 386 N - AF2 AF2
ICL3 387 P - AF2 AF2
TM6 388 P 6.24x24 AF2 AF2
TM6 389 L 6.25x25 AF2 AF2
TM6 390 P 6.26x26 AF2 AF2
TM6 391 R 6.27x27 Structure Structure
TM6 392 C 6.28x28 Structure Structure
TM6 393 Y 6.29x29 Structure AF2
TM6 394 Q 6.30x30 Structure Structure
TM6 395 C 6.31x31 Structure Structure
TM6 396 K 6.32x32 Structure Structure
TM6 397 A 6.33x33 Structure Structure
TM6 398 A 6.34x34 Structure Structure
TM6 399 K 6.35x35 Structure Structure
TM6 400 V 6.36x36 Structure Structure
TM6 401 I 6.37x37 Structure Structure
TM6 402 F 6.38x38 Structure Structure
TM6 403 I 6.39x39 Structure Structure
TM6 404 I 6.40x40 Structure Structure
TM6 405 I 6.41x41 Structure Structure
TM6 406 F 6.42x42 Structure Structure
TM6 407 S 6.43x43 Structure Structure
TM6 408 Y 6.44x44 Structure Structure
TM6 409 V 6.45x45 Structure Structure
TM6 410 L 6.46x46 Structure Structure
TM6 411 S 6.47x47 Structure Structure
TM6 412 L 6.48x48 Structure Structure
TM6 413 G 6.49x49 Structure Structure
TM6 414 P 6.50x50 Structure Structure
TM6 415 Y 6.51x51 Structure Structure
TM6 416 C 6.52x52 Structure Structure
TM6 417 F 6.53x53 Structure Structure
TM6 418 L 6.54x54 Structure Structure
TM6 419 A 6.55x55 Structure Structure
TM6 420 V 6.56x56 Structure Structure
TM6 421 L 6.57x57 Structure Structure
TM6 422 A 6.58x58 Structure Structure
TM6 423 V 6.59x59 Structure Structure
TM6 424 W 6.60x60 Structure Structure
TM6 425 V 6.61x61 Structure Structure
ECL3 426 D - Structure AF2
ECL3 427 V - Structure Structure
ECL3 428 E - Structure Structure
ECL3 429 T - Structure Structure
ECL3 430 Q - Structure Structure
ECL3 431 V - Structure Structure
TM7 432 P 7.31x30 Structure Structure
TM7 433 Q 7.32x31 Structure Structure
TM7 434 W 7.33x32 Structure Structure
TM7 435 V 7.34x33 Structure Structure
TM7 436 I 7.35x34 Structure Structure
TM7 437 T 7.36x35 Structure Structure
TM7 438 I 7.37x36 Structure Structure
TM7 439 I 7.38x37 Structure Structure
TM7 440 I 7.39x38 Structure Structure
TM7 441 W 7.40x39 Structure Structure
TM7 442 L 7.41x40 Structure Structure
TM7 443 F 7.42x41 Structure Structure
TM7 444 F 7.43x42 Structure Structure
TM7 445 L 7.44x43 Structure Structure
TM7 446 Q 7.45x45 Structure Structure
TM7 447 C 7.46x46 Structure Structure
TM7 448 C 7.47x47 Structure Structure
TM7 449 I 7.48x48 Structure Structure
TM7 450 H 7.49x49 Structure Structure
TM7 451 P 7.50x50 Structure Structure
TM7 452 Y 7.51x51 Structure Structure
TM7 453 V 7.52x52 Structure Structure
TM7 454 Y 7.53x53 Structure Structure
TM7 455 G 7.54x54 Structure Structure
TM7 456 Y 7.55x55 Structure Structure
TM7 457 M 7.56x56 Structure Structure
H8 458 H 8.47x47 Structure Structure
H8 459 K 8.48x48 Structure Structure
H8 460 T 8.49x49 Structure Structure
H8 461 I 8.50x50 Structure Structure
H8 462 K 8.51x51 Structure Structure
H8 463 K 8.52x52 Structure Structure
H8 464 E 8.53x53 Structure Structure
H8 465 I 8.54x54 Structure Structure
H8 466 Q 8.55x55 Structure Structure
H8 467 D 8.56x56 Structure Structure
H8 468 M 8.57x57 Structure Structure
H8 469 L 8.58x58 Structure Structure
H8 470 K 8.59x59 Structure Structure
H8 471 K 8.60x60 Structure Structure
H8 472 F 8.61x61 Structure Structure
H8 473 F 8.62x62 Structure Structure
C-term 474 C - AF2 AF2
C-term 475 K - AF2 AF2
C-term 476 E - AF2 AF2
C-term 477 K - AF2 AF2
C-term 478 P - AF2 AF2
C-term 479 P - AF2 AF2
C-term 480 K - AF2 AF2
C-term 481 E - AF2 AF2
C-term 482 D - AF2 AF2
C-term 483 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 V 215 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 V 215 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 226 5x72 G.H5 L 394 G.H5.26
Van-der-waals TM7 M 457 7x56 G.H5 E 392 G.H5.24
Polar H8 K 459 8x48 G.H5 Q 390 G.H5.22
Hydrophobic H8 K 459 8x48 G.H5 Q 390 G.H5.22
Van-der-waals H8 K 459 8x48 G.H5 Q 390 G.H5.22
Ionic TM5 R 221 5x67 G.H5 D 381 G.H5.13
Polar TM5 R 221 5x67 G.H5 D 381 G.H5.13
Hydrophobic ICL3 H 232 - G.hgh4 P 321 G.hgh4.11
Van-der-waals ICL3 H 232 - G.hgh4 P 321 G.hgh4.11
Polar ICL2 L 137 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 137 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM6 V 400 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 V 400 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 400 6x36 G.H5 L 393 G.H5.25
Ionic ICL3 H 232 - G.H4 D 343 G.H4.13
Polar ICL3 H 232 - G.H4 D 343 G.H4.13
Hydrophobic ICL3 H 232 - G.H4 D 343 G.H4.13
Hydrophobic ICL3 V 236 - G.hgh4 Y 318 G.hgh4.08
Polar ICL2 M 143 34x57 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 M 143 34x57 G.hns1 R 38 G.hns1.02
Aromatic TM3 R 129 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 129 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 129 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM6 I 401 6x37 G.H5 L 393 G.H5.25
Polar ICL3 H 232 - G.H4 R 342 G.H4.12
Aromatic ICL3 H 232 - G.H4 R 342 G.H4.12
Hydrophobic ICL3 H 232 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 H 232 - G.H4 R 342 G.H4.12
Hydrophobic ICL2 L 137 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 137 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM3 I 133 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 Q 222 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 222 5x68 G.H5 R 385 G.H5.17
Hydrophobic H8 K 459 8x48 G.H5 R 389 G.H5.21
Hydrophobic ICL3 H 232 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 A 218 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 A 218 5x64 G.H5 Q 384 G.H5.16
Aromatic H8 H 458 8x47 G.H5 Y 391 G.H5.23
Hydrophobic H8 H 458 8x47 G.H5 Y 391 G.H5.23
Van-der-waals H8 H 458 8x47 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 140 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic TM5 H 223 5x69 G.H5 L 394 G.H5.26
Ionic H8 K 462 8x51 G.H5 E 392 G.H5.24
Polar ICL1 Q 61 12x49 G.HN K 34 G.HN.51
Hydrophobic ICL1 Q 61 12x49 G.HN K 34 G.HN.51
Hydrophobic C-term S 483 - G.H3 W 281 G.H3.17
Van-der-waals C-term S 483 - G.H3 W 281 G.H3.17
Hydrophobic ICL2 P 136 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 133 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 137 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL2 L 137 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM3 I 133 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 133 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 136 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 136 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 L 226 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 L 226 5x72 G.h4s6 Y 358 G.h4s6.20
Polar TM3 I 133 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 133 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 133 3x54 G.H5 Q 384 G.H5.16
Van-der-waals C-term D 482 - G.H3 W 281 G.H3.17
Hydrophobic C-term D 482 - G.H3 W 281 G.H3.17
Hydrophobic H8 K 459 8x48 G.H5 E 392 G.H5.24
Polar ICL2 P 140 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 P 140 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 P 140 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 L 226 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 L 226 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL3 V 236 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 V 236 - G.H4 D 343 G.H4.13
Hydrophobic TM2 V 65 2x38 G.hns1 R 38 G.hns1.02
Ionic TM6 K 396 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 396 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 396 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 A 397 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 396 6x32 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 396 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 137 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 L 137 34x51 G.H5 R 380 G.H5.12
Van-der-waals TM4 T 144 4x38 G.hns1 R 38 G.hns1.02
Polar TM2 Q 64 2x37 G.hns1 R 38 G.hns1.02
Hydrophobic TM2 Q 64 2x37 G.hns1 R 38 G.hns1.02
Van-der-waals TM2 Q 64 2x37 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 Q 222 5x68 G.H5 L 388 G.H5.20
Polar H8 H 458 8x47 G.H5 Q 390 G.H5.22
Hydrophobic H8 H 458 8x47 G.H5 Q 390 G.H5.22
Polar ICL2 P 140 34x54 G.HN Q 35 G.HN.52
Hydrophobic TM3 I 133 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 Q 222 5x68 G.H5 L 394 G.H5.26
Polar TM3 S 132 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 S 132 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 132 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM4 T 144 4x38 G.HN Q 35 G.HN.52
Hydrophobic ICL2 L 137 34x51 G.S3 F 219 G.S3.03
Van-der-waals ICL2 L 137 34x51 G.S3 F 219 G.S3.03
Hydrophobic TM5 A 219 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 137 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 137 34x51 G.H5 F 376 G.H5.08
Polar TM3 I 134 3x55 G.H5 R 380 G.H5.12
Hydrophobic H8 T 460 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 T 460 8x49 G.H5 Q 390 G.H5.22