A3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Ovis aries

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Bos taurus

PDB CODE

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

Nov. 6, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

CHEMBL383144 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic ICL2 V 116 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 I 203 5x65 G.H5 F 354 G.H5.26
Van-der-waals TM5 I 203 5x65 G.H5 F 354 G.H5.26
Polar TM3 R 111 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 111 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 207 5x69 G.H5 F 354 G.H5.26
Hydrophobic TM3 V 112 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM7 K 284 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 K 284 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM5 I 203 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 203 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 V 116 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM5 R 206 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 I 199 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 207 5x69 G.H5 K 345 G.H5.17
Van-der-waals TM5 L 207 5x69 G.H5 K 345 G.H5.17
Ionic TM5 R 206 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 206 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 206 5x68 G.H5 D 341 G.H5.13
Ionic ICL2 R 120 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 120 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM7 I 285 7x57 G.H5 G 352 G.H5.24
Van-der-waals TM7 I 285 7x57 G.H5 G 352 G.H5.24
Hydrophobic ICL2 R 120 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM7 I 285 7x57 G.H5 C 351 G.H5.23
Van-der-waals TM7 I 285 7x57 G.H5 C 351 G.H5.23
Polar TM3 R 108 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 108 3x50 G.H5 C 351 G.H5.23
Polar TM6 T 227 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 227 6x33 G.H5 L 353 G.H5.25
Ionic TM3 R 111 3x53 G.H5 D 350 G.H5.22
Polar TM3 R 111 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 231 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 231 6x37 G.H5 L 353 G.H5.25
Ionic H8 K 287 8x49 G.H5 D 350 G.H5.22
Polar H8 K 287 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 K 287 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 K 287 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 108 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 108 3x50 G.H5 L 353 G.H5.25