TAS2R14 (t2r14_human)

FAMILY

Class T2 (Taste 2) Sensory receptors Taste 2 receptors TAS2R14

GENE

TAS2R14

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Taste receptor type 2 member 14, T2R14, Taste receptor family B member 1, TRB1

SOURCE

SWISSPROT

SEQUENCE

TM1              
M
G
G
V
I
K
S
I
F
T
10
                   
F
V
L
I
V
E
F
I
I
G
20
                   
N
L
G
N
S
F
I
A
L
V
30
                   
N
C
I
D
W
V
K
G
R
K
40
ICL1 TM2      
I
S
S
V
D
R
I
L
T
A
50
                   
L
A
I
S
R
I
S
L
V
W
60
                   
L
I
F
G
S
W
C
V
S
V
70
    ECL1   TM3
F
F
P
A
L
F
A
T
E
K
80
                   
M
F
R
M
L
T
N
I
W
T
90
                   
V
I
N
H
F
S
V
W
L
A
100
                   
T
G
L
G
T
F
Y
F
L
K
110
    ICL2        
I
A
N
F
S
N
S
I
F
L
120
        TM4      
Y
L
K
W
R
V
K
K
V
V
130
                   
L
V
L
L
L
V
T
S
V
F
140
                   
L
F
L
N
I
A
L
I
N
I
150
      ECL2      
H
I
N
A
S
I
N
G
Y
R
160
                   
R
N
K
T
C
S
S
D
S
S
170
                   
N
F
T
R
F
S
S
L
I
V
180
TM5              
L
T
S
T
V
F
I
F
I
P
190
                   
F
T
L
S
L
A
M
F
L
L
200
                   
L
I
F
S
M
W
K
H
R
K
210
            ICL3
K
M
Q
H
T
V
K
I
S
G
220
            TM6  
D
A
S
T
K
A
H
R
G
V
230
                   
K
S
V
I
T
F
F
L
L
Y
240
                   
A
I
F
S
L
S
F
F
I
S
250
                   
V
W
T
S
E
R
L
E
E
N
260
TM7              
L
I
I
L
S
Q
V
M
G
M
270
                   
A
Y
P
S
C
H
S
C
V
L
280
      H8          
I
L
G
N
K
K
L
R
Q
A
290
                   
S
L
S
V
L
L
W
L
R
Y
300
        C-term
M
F
K
D
G
E
P
S
G
H
310
             
K
E
F
R
E
S
S

LINKS

DIAGRAMS

7TM

ICL1 R K I ICL1ECL1 P A L F A ECL1ICL2 N F S N S I F L Y L K W ICL2ECL2 A S I N G Y R R N K T C S S D S S N F T R F S S L ECL2ICL3 K I S G D A S T K A ICL3ECL3 E E ECL3C-term G E P S G H K E F R E S S C-term M G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A R V K K V V L V L L L V T S V F L F L N I A L I N I H I N I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V H R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L N L I I L S Q V M G M A Y P S C H S C V L I L G N K K S L S L R Y L R Q A V L L W M F K D
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

S N G L N G I I F E V I L V F T F I S K 1 T A L A I S R I S L V W L I F G S W C V 2 G T A L W V S F H N I V T W I N T L M R 3 V L V L L L V T S V F L F L N I A L I N 4 F M A L S L T F P I F I F V T S T L V I 5 V I T F F L L Y A I F S L S F F I S V W 6 C S H C S P Y A M G M V Q S L I I L N 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

STRUCTURES

Found 14 structure(s) - view all details on the Structures page

PDBs: 8VY9, 8VY7, 8XQL, 8XQN, 8XQO, 8XQP, 8XQR, 8XQS, 8XQT, 8YKY, 9IIX, 9IIW, 9IJ9, 9IJA