GPCR CLASS (FAMILY)
GPCR SPECIES
GPCR PREFERRED CHAIN
G PROTEIN (FAMILY)
G PROTEIN SPECIES
PDB CODE
RESOLUTION
REFERENCE
PUBLICATION DATE
LIGAND INTERACTIONS
LIGANDS
5-hydroxytryptamine - Agonist pubchem gtoplig chembl_ligand drugbank
ENDOGENOUS LIGANDS
5-hydroxytryptamine
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | I | 121 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | H8 | N | 315 | 8x47 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | H8 | N | 315 | 8x47 | G.H5 | Q | 390 | G.H5.22 |
Polar | TM3 | I | 121 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | I | 121 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | A | 231 | 5x78 | G.H4 | L | 346 | G.H4.16 |
Van-der-waals | TM5 | A | 231 | 5x78 | G.H4 | L | 346 | G.H4.16 |
Polar | TM6 | A | 256 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | A | 256 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | A | 256 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Polar | TM5 | A | 233 | 5x80 | G.H4 | R | 347 | G.H4.17 |
Van-der-waals | TM5 | A | 233 | 5x80 | G.H4 | R | 347 | G.H4.17 |
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Polar | TM6 | K | 255 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | K | 255 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | K | 255 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | N | 130 | 34x55 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | N | 130 | 34x55 | G.hns1 | R | 38 | G.hns1.02 |
Ionic | H8 | K | 316 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | K | 316 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | K | 316 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Ionic | TM5 | R | 230 | 5x77 | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | TM5 | R | 230 | 5x77 | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | TM5 | R | 230 | 5x77 | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | TM5 | M | 227 | 5x74 | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | TM5 | M | 227 | 5x74 | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | TM5 | I | 214 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM5 | I | 214 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Polar | H8 | K | 316 | 8x48 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | H8 | K | 316 | 8x48 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | H8 | K | 316 | 8x48 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM6 | L | 260 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | L | 126 | 34x51 | G.H5 | C | 379 | G.H5.11 |
Van-der-waals | ICL2 | L | 126 | 34x51 | G.H5 | C | 379 | G.H5.11 |
Polar | ICL2 | L | 126 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | L | 126 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | L | 126 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | TM5 | I | 225 | 5x72 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | I | 225 | 5x72 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | A | 231 | 5x78 | G.H4 | D | 343 | G.H4.13 |
Van-der-waals | TM5 | A | 231 | 5x78 | G.H4 | D | 343 | G.H4.13 |
Hydrophobic | TM5 | L | 228 | 5x75 | G.H4 | L | 346 | G.H4.16 |
Van-der-waals | TM5 | L | 228 | 5x75 | G.H4 | L | 346 | G.H4.16 |
Polar | ICL2 | N | 130 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | ICL2 | N | 130 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | ICL2 | N | 130 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | ICL2 | L | 126 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | L | 126 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | ICL2 | V | 127 | 34x52 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | I | 121 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Polar | TM6 | T | 259 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | T | 259 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM5 | A | 218 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | A | 218 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Polar | TM7 | L | 314 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM7 | L | 314 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | L | 314 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM5 | H | 221 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | H | 221 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Polar | TM5 | L | 228 | 5x75 | G.h4s6 | T | 350 | G.h4s6.03 |
Van-der-waals | TM5 | L | 228 | 5x75 | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | TM5 | G | 232 | 5x79 | G.H4 | R | 347 | G.H4.17 |
Van-der-waals | TM5 | G | 232 | 5x79 | G.H4 | R | 347 | G.H4.17 |
Hydrophobic | ICL2 | P | 125 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Aromatic | TM3 | R | 117 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 117 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | R | 117 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM5 | H | 221 | 5x68 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | T | 259 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | T | 259 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | L | 126 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | L | 126 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | TM2 | T | 54 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM5 | I | 214 | 5x61 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | L | 126 | 34x51 | G.S3 | F | 219 | G.S3.03 |
Van-der-waals | ICL2 | L | 126 | 34x51 | G.S3 | F | 219 | G.S3.03 |
Van-der-waals | TM5 | L | 228 | 5x75 | G.S6 | C | 359 | G.S6.01 |
Van-der-waals | TM7 | L | 314 | 7x56 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM5 | H | 221 | 5x68 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | H | 221 | 5x68 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | C | 122 | 3x55 | G.H5 | Q | 384 | G.H5.16 |
Polar | H8 | N | 315 | 8x47 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | H8 | N | 315 | 8x47 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | H8 | N | 315 | 8x47 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | P | 125 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | P | 125 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | TM5 | A | 222 | 5x69 | G.H5 | L | 394 | G.H5.26 |
Ionic | H8 | R | 319 | 8x51 | G.H5 | E | 392 | G.H5.24 |
Polar | TM5 | H | 221 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | H | 221 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | H | 221 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | H8 | K | 316 | 8x48 | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | H8 | K | 316 | 8x48 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | TM5 | A | 231 | 5x78 | G.H4 | R | 342 | G.H4.12 |
Van-der-waals | TM5 | A | 231 | 5x78 | G.H4 | R | 342 | G.H4.12 |
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | I | 121 | 3x54 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM5 | G | 232 | 5x79 | G.H4 | L | 346 | G.H4.16 |
Van-der-waals | TM5 | G | 232 | 5x79 | G.H4 | L | 346 | G.H4.16 |
Ionic | TM6 | K | 255 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Polar | TM6 | K | 255 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | K | 255 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | K | 255 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM5 | I | 225 | 5x72 | G.H5 | L | 394 | G.H5.26 |
Polar | ICL2 | N | 130 | 34x55 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ICL2 | N | 130 | 34x55 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM5 | I | 225 | 5x72 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM5 | Q | 229 | 5x76 | G.h4s6 | T | 350 | G.h4s6.03 |
Van-der-waals | TM5 | Q | 229 | 5x76 | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | TM5 | L | 228 | 5x75 | G.S6 | P | 361 | G.S6.03 |
Hydrophobic | ICL2 | P | 125 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | T | 217 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL2 | R | 129 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | R | 129 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | R | 129 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM5 | H | 221 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | H | 221 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | H | 221 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM3 | A | 120 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | A | 120 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Polar | TM5 | Q | 224 | 5x71 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | Q | 224 | 5x71 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | G | 232 | 5x79 | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | ICL2 | L | 126 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | L | 126 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL2 | L | 126 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | L | 126 | 34x51 | G.H5 | F | 376 | G.H5.08 |