TA1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8JLO

RESOLUTION

3.5 Å

REFERENCE

10.1038/S41586-023-06804-Z

PUBLICATION DATE

Nov. 15, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

22 interactions (Click to see)

LIGANDS

ulotaront - Agonist pubchem gtoplig drugbank chembl_ligand

PHYSIOLOGICAL LIGANDS

octopamine, β-phenylethylamine, CHEMBL1160703, tyramine, (+)-Octopamine, 3-iodothyronamine, dopamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 K 248 6x32 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 128 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 128 - G.H5 I 383 G.H5.15
Aromatic ICL2 Y 131 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 131 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 131 - G.H5 H 387 G.H5.19
Ionic TM6 K 248 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 248 6x32 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 129 - G.S3 F 219 G.S3.03
Hydrophobic TM5 I 213 5x61 G.H5 L 393 G.H5.25
Aromatic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Polar TM5 Q 220 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 220 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 220 5x68 G.H5 Q 384 G.H5.16
Ionic ICL2 R 130 - G.s2s3 D 215 G.s2s3.01
Polar ICL2 R 130 - G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 130 - G.s2s3 D 215 G.s2s3.01
Polar TM6 T 252 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 252 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM5 Q 220 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM3 V 125 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 125 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM4 N 136 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 Q 220 5x68 G.H5 L 394 G.H5.26
Van-der-waals TM5 Q 220 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM3 V 125 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 V 125 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 253 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 128 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 128 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 R 130 - G.S3 V 217 G.S3.01
Hydrophobic TM5 I 224 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 224 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 129 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 129 - G.H5 F 376 G.H5.08
Polar ICL2 L 129 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 129 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 129 - G.S1 H 41 G.S1.02
Hydrophobic TM3 A 124 3x53 G.H5 Y 391 G.H5.23
Polar TM3 A 124 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 129 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 129 - G.H5 I 383 G.H5.15
Hydrophobic TM5 I 216 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 129 - G.S3 V 217 G.S3.01
Hydrophobic TM5 A 217 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 224 5x72 G.h4s6 Y 358 G.h4s6.20
Polar TM6 A 249 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 249 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 249 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 231 5x79 G.h4s6 T 350 G.h4s6.03
Polar ICL2 K 132 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 K 248 6x32 G.H5 L 394 G.H5.26
Hydrophobic H8 P 309 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 P 309 8x48 G.H5 E 392 G.H5.24