NTS1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

June 3, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

JMV449 - Agonist pubchem gtoplig

PHYSIOLOGICAL LIGANDS

large neuromedin N (Mouse), neurotensin (Human), neuromedin N (Human), large neuromedin N (Human), large neuromedin N (Rat), large neurotensin (Human), neuromedin N (Mouse)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic TM7 V 367 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 V 367 7x56 G.H5 F 354 G.H5.26
Hydrophobic ICL2 T 178 34x55 G.HN R 24 G.HN.48
Van-der-waals ICL2 T 178 34x55 G.HN R 24 G.HN.48
Hydrophobic ICL2 K 175 34x52 G.HN E 28 G.HN.52
Hydrophobic ICL2 F 174 34x51 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 R 294 6x26 G.H5 I 344 G.H5.16
Van-der-waals TM6 R 294 6x26 G.H5 I 344 G.H5.16
Ionic TM6 R 294 6x26 G.H5 D 341 G.H5.13
Polar TM6 R 294 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 294 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 294 6x26 G.H5 D 341 G.H5.13
Hydrophobic ICL2 F 174 34x51 G.HN E 28 G.HN.52
Hydrophobic TM2 V 101 2x39 G.H5 L 353 G.H5.25
Van-der-waals TM2 V 101 2x39 G.H5 L 353 G.H5.25
Polar TM3 R 166 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 166 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 166 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM2 V 101 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 V 101 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM7 V 367 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 V 367 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 169 3x53 G.H5 C 351 G.H5.23
Hydrophobic H8 I 374 8x53 G.H5 F 354 G.H5.26
Hydrophobic TM6 A 297 6x29 G.H5 L 348 G.H5.20
Hydrophobic TM2 L 97 2x35 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 298 6x30 G.H5 I 344 G.H5.16
Hydrophobic TM2 L 97 2x35 G.H5 K 349 G.H5.21
Van-der-waals TM2 L 97 2x35 G.H5 K 349 G.H5.21
Hydrophobic TM3 I 170 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 170 3x54 G.H5 C 351 G.H5.23
Polar ICL2 T 178 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 T 178 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 T 178 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 K 177 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM2 V 101 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 298 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM2 L 105 2x43 G.H5 L 353 G.H5.25
Polar H8 N 370 8x49 G.H5 F 354 G.H5.26
Hydrophobic H8 N 370 8x49 G.H5 F 354 G.H5.26
Hydrophobic TM7 Y 364 7x53 G.H5 L 353 G.H5.25
Aromatic ICL2 F 174 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 174 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 F 174 34x51 G.hns1 R 32 G.hns1.03