κ receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9V6O

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41467-025-64882-1

PUBLICATION DATE

Nov. 19, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

46 interactions (Click to see)

LIGANDS

nalfurafine - Agonist pubchem gtoplig chembl_ligand drug_central drugbank

PHYSIOLOGICAL LIGANDS

[Met]enkephalin (Human), β-neoendorphin (Human), dynorphin A (Human), dynorphin A-(1-8) (Human), dynorphin A-(1-13) (Human), big dynorphin (Human), β-endorphin (Mouse), β-endorphin (Rat), dynorphin B (Human), β-endorphin (Human), α-neoendorphin (Human), [Leu]enkephalin (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 L 258 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 P 163 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM6 I 272 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 I 272 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM5 V 256 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 253 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 253 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 I 272 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 156 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 256 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 256 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM4 T 171 4x38 G.HN E 28 G.HN.52
Hydrophobic H8 E 335 8x48 G.H5 L 353 G.H5.25
Hydrophobic H8 N 336 8x49 G.H5 G 352 G.H5.24
Hydrophobic TM3 A 159 3x53 G.H5 C 351 G.H5.23
Polar H8 E 335 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 E 335 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 335 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 164 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM5 R 252 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 252 5x64 G.H5 I 344 G.H5.16
Polar TM3 A 159 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 159 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 159 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL3 L 258 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 L 258 - G.H5 K 345 G.H5.17
Hydrophobic TM6 I 272 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 272 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 167 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM3 V 160 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 163 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 163 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 L 275 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 275 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 167 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 164 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 L 167 34x54 G.S3 L 194 G.S3.01
Polar ICL2 R 170 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 170 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 170 34x57 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 94 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 94 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 M 249 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 M 249 5x61 G.H5 L 353 G.H5.25
Ionic ICL2 R 170 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 170 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 170 34x57 G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 170 34x57 G.H5 D 350 G.H5.22
Hydrophobic TM5 L 253 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 164 34x51 G.S3 L 194 G.S3.01
Hydrophobic H8 D 334 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 D 334 8x47 G.H5 G 352 G.H5.24
Polar ICL3 R 257 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 257 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 257 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 163 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 163 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 D 168 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 168 34x55 G.hns1 R 32 G.hns1.03
Polar TM3 R 156 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 156 3x50 G.H5 C 351 G.H5.23
Polar H8 E 335 8x48 G.H5 G 352 G.H5.24
Hydrophobic H8 E 335 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 E 335 8x48 G.H5 G 352 G.H5.24
Polar TM2 T 94 2x39 G.H5 D 350 G.H5.22