GPR119 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Dec. 21, 2022

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

AR231453 - Agonist pubchem gtoplig chembl_ligand

ENDOGENOUS LIGANDS

N-oleoylethanolamide, anandamide, N-palmitoylethanolamine, SEA



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 F 111 34x51 G.S3 F 219 G.S3.03
Ionic ICL1 D 37 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 F 111 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 111 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM5 E 203 5x77 G.h4s6 T 350 G.h4s6.03
Polar TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM6 V 227 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 227 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM5 A 209 5x83 G.hgh4 Y 318 G.hgh4.08
Hydrophobic TM5 M 202 5x76 G.S6 C 359 G.S6.01
Van-der-waals TM5 M 202 5x76 G.S6 C 359 G.S6.01
Hydrophobic ICL2 P 110 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 110 34x50 G.H5 Q 384 G.H5.16
Ionic TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Polar TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Ionic TM5 H 195 5x69 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 195 5x69 G.H5 D 381 G.H5.13
Polar ICL2 S 118 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 S 118 - G.HN Q 35 G.HN.52
Hydrophobic TM5 G 206 5x80 G.H4 R 347 G.H4.17
Hydrophobic TM5 M 202 5x76 G.S6 P 361 G.S6.03
Van-der-waals TM5 M 202 5x76 G.S6 P 361 G.S6.03
Ionic ICL1 D 37 - G.HN K 34 G.HN.51
Hydrophobic TM3 I 107 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 107 3x54 G.H5 Y 391 G.H5.23
Aromatic ICL2 F 111 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 111 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 111 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM5 A 205 5x79 G.H4 L 346 G.H4.16
Hydrophobic TM3 I 107 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 114 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 114 34x54 G.S1 H 41 G.S1.02
Hydrophobic TM5 H 195 5x69 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 110 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM5 A 192 5x66 G.H5 L 388 G.H5.20
Ionic ICL3 K 222 - G.H5 E 392 G.H5.24
Polar ICL3 K 222 - G.H5 E 392 G.H5.24
Van-der-waals ICL3 K 222 - G.H5 E 392 G.H5.24
Polar TM6 T 226 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 226 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM5 H 195 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 M 188 5x62 G.H5 L 393 G.H5.25
Hydrophobic TM5 A 209 5x83 G.H4 D 343 G.H4.13
Hydrophobic TM5 G 206 5x80 G.H4 L 346 G.H4.16
Hydrophobic ICL3 K 222 - G.H5 L 394 G.H5.26
Polar TM5 H 195 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 195 5x69 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 195 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 I 199 5x73 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 199 5x73 G.H5 R 385 G.H5.17
Polar TM3 A 106 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 106 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL3 G 210 - G.H4 R 347 G.H4.17
Polar TM5 Q 198 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM5 I 199 5x73 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 K 115 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 F 111 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM5 I 191 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM6 A 223 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 223 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 111 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM5 I 199 5x73 G.H5 L 394 G.H5.26
Aromatic ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 A 192 5x66 G.H5 L 393 G.H5.25
Hydrophobic TM5 M 202 5x76 G.H4 L 346 G.H4.16
Hydrophobic TM3 I 107 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 107 3x54 G.H5 L 388 G.H5.20
Polar TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Aromatic TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Polar ICL2 K 115 34x55 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 K 115 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 P 110 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 110 34x50 G.H5 I 383 G.H5.15