GPR119 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7WCN

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41467-022-34696-6

PUBLICATION DATE

Dec. 21, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

44 interactions (Click to see)

LIGANDS

AR231453 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

N-palmitoylethanolamine, anandamide, N-oleoylethanolamide, SEA



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 111 34x51 G.H5 I 383 G.H5.15
Polar TM5 H 195 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 195 5x69 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 195 5x69 G.H5 R 385 G.H5.17
Ionic TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Polar TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 H 195 5x69 G.H5 L 388 G.H5.20
Polar ICL2 K 115 34x55 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 K 115 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM5 A 209 5x83 G.H4 D 343 G.H4.13
Ionic ICL1 D 37 - G.hns1 R 38 G.hns1.02
Aromatic ICL2 F 111 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 111 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 111 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM5 M 202 5x76 G.S6 P 361 G.S6.03
Van-der-waals TM5 M 202 5x76 G.S6 P 361 G.S6.03
Hydrophobic TM5 I 191 5x65 G.H5 L 388 G.H5.20
Polar ICL2 S 118 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 S 118 - G.HN Q 35 G.HN.52
Ionic TM5 H 195 5x69 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 195 5x69 G.H5 D 381 G.H5.13
Hydrophobic TM5 G 206 5x80 G.H4 L 346 G.H4.16
Hydrophobic ICL3 K 222 - G.H5 L 394 G.H5.26
Hydrophobic TM6 A 223 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 223 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 A 192 5x66 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 111 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL3 G 210 - G.H4 R 347 G.H4.17
Hydrophobic TM5 I 199 5x73 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 199 5x73 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 199 5x73 G.H5 R 385 G.H5.17
Hydrophobic TM5 M 188 5x62 G.H5 L 393 G.H5.25
Hydrophobic TM5 A 205 5x79 G.H4 L 346 G.H4.16
Hydrophobic ICL2 K 115 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM3 I 107 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 107 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 G 206 5x80 G.H4 R 347 G.H4.17
Hydrophobic TM3 I 107 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 111 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 F 111 34x51 G.S3 F 219 G.S3.03
Polar TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM6 V 227 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 227 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM5 A 192 5x66 G.H5 L 393 G.H5.25
Aromatic ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 A 209 5x83 G.hgh4 Y 318 G.hgh4.08
Aromatic TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Polar TM6 T 226 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 226 6x36 G.H5 E 392 G.H5.24
Polar TM5 Q 198 5x72 G.H5 R 385 G.H5.17
Ionic ICL1 D 37 - G.HN K 34 G.HN.51
Hydrophobic TM5 H 195 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 M 202 5x76 G.H4 L 346 G.H4.16
Hydrophobic TM5 I 199 5x73 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 P 110 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 110 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 110 34x50 G.H5 I 383 G.H5.15
Polar TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 107 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 107 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 110 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 110 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 M 202 5x76 G.S6 C 359 G.S6.01
Van-der-waals TM5 M 202 5x76 G.S6 C 359 G.S6.01
Polar TM3 A 106 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 106 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 E 203 5x77 G.h4s6 T 350 G.h4s6.03
Ionic ICL3 K 222 - G.H5 E 392 G.H5.24
Polar ICL3 K 222 - G.H5 E 392 G.H5.24
Van-der-waals ICL3 K 222 - G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 111 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 114 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 114 34x54 G.S1 H 41 G.S1.02