Structure information

GPR119

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7WCN

SPECIES

Homo sapiens

RESOLUTION

2.870

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-34696-6

PUBLICATION DATE

Dec. 21, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
AR231453 L61 2.60x60 TM2 hydrophobic
AR231453 V85 3.32x32 TM3 polar (hydrogen bond with backbone)
AR231453 V85 3.32x32 TM3 Van der Waals
AR231453 T86 3.33x33 TM3 Van der Waals
AR231453 A89 3.36x36 TM3 hydrophobic
AR231453 A89 3.36x36 TM3 Van der Waals
AR231453 A90 3.37x37 TM3 Van der Waals
AR231453 V93 3.40x40 TM3 hydrophobic
AR231453 V93 3.40x40 TM3 Van der Waals
AR231453 S156 45.51x51 ECL2 Van der Waals
AR231453 F157 45.52x52 ECL2 aromatic (face-to-edge)
AR231453 F157 45.52x52 ECL2 Van der Waals
AR231453 F157 45.52x52 ECL2 polar (hydrogen bond with backbone)
AR231453 L169 5.43x44 TM5 Van der Waals
AR231453 G173 5.47x47 TM5 Van der Waals
AR231453 F174 5.48x48 TM5 Van der Waals
AR231453 W238 6.48x48 TM6 Van der Waals
AR231453 W238 6.48x48 TM6 hydrophobic
AR231453 F241 6.51x51 TM6 Van der Waals
AR231453 E261 7.35x34 TM7 polar (charge-assisted hydrogen bond)
AR231453 W265 7.39x38 TM7 polar (hydrogen bond)

Ligands

AR231453

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Residue Diagrams

T N T A I I L S A L V A L I V G F S F S 1 L N L A V A D T L I G V A I S G L L T D 2 L M V T L V S A A A S S T V F A M R L S 3 A G A C I A G L W L V S Y L I G F L P L 4 F F V F L L M A P F F G V C S L T L V F H 5 S V L I G S F A L S W T P F L I T G I V 6 L P N L L S N G V G L L W L Y R E L V 7
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ICL1 I H K N D ICL1ECL1 S P S ECL1ICL2 P F R Y L K I M ICL2ECL2 P M F Q Q T A Y K G Q C S F F A V ECL2ICL3 A M A G G Y ICL3ECL3 Q E C H L ECL3C-term G V K K V L T S F L L F L S A R N C G P E R P R E S S C H I V T I S S S E F D G C-term M E S S F S F G V I L A V L A S L I I A T N T L V A V A V L L L G V S L C F T L N L A V A D T L I G V A I S G L L T D Q L S R P T Q K T L C S L R M A F V T S S A A A S V L T V M L I T F D R Y L A I K Q S G F V A G A C I A G L W L V S Y L I G F L P L G I F H P H F V L T L S C V G F F P A M L L F V F F Y C D M L K I A S M H S Q Q I R K M E H A G R S P R T P S D F K A L R T V S V L I G S F A L S W T P F L I T G I V Q V A C Y L V L E R Y L W L L G V G N S L L N P L I Y A Y W Q K E L Y H V R L Q M A L
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR119
TM2
2x60 2.60x60 L61
TM3
3x32 3.32x32 V85
3x33 3.33x33 T86
3x36 3.36x36 A89
3x37 3.37x37 A90
3x40 3.40x40 V93
ECL2
45x51 45.51x51 S156
45x52 45.52x52 F157
TM5
5x44 5.43x44 L169
5x47 5.47x47 G173
5x48 5.48x48 F174
TM6
6x48 6.48x48 W238
6x51 6.51x51 F241
TM7
7x34 7.35x34 E261
7x38 7.39x38 W265