GPCRdb

ciforadenant

Agent/drug
Bioactivity

ciforadenant

SMILES	Cc1ccc(-c2nc(N)nc3c2nnn3Cc2cccc(CO[C@H]3CCOC3)n2)o1
InChIKey	KURQKNMKCGYWRJ-HNNXBMFYSA-N

Chemical Properties

Hydrogen bond acceptors	10
Hydrogen bond donors	1
Rotatable bonds	6
Molecular weight (Da)	407.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

A₁	AA1R	Human	Adenosine	A	pKi	6.72	6.72	6.72	ChEMBL
A_2A	AA2AR	Human	Adenosine	A	pKi	8.47	8.47	8.47	ChEMBL
A_2B	AA2BR	Human	Adenosine	A	pKi	5.40	5.40	5.40	ChEMBL
A₃	AA3R	Human	Adenosine	A	pKi	5.60	5.60	5.60	ChEMBL

Showing 1 to 4 of 4 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

A_2A	AA2AR	Human	Adenosine	A	pIC50	5.47	6.94	7.77	ChEMBL

Showing 1 to 1 of 1 entry

ciforadenant

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 4

Phase II 1

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Attention deficit hyperactivity disorder, presentation unspecified	6A05.Z		0.388	1	No
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Other specified malignant neoplasms of bronchus or lung	2C25.Y		0.120	1	No
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Parkinson disease, unspecified	8A00.0Z		0.573	1	No
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Plasma cell myeloma	2A83.1		0.038	1	No
AA2AR	A_2A receptor	Adenosine receptors	Nucleotide receptors	Class A	Renal cell carcinoma of kidney, except renal pelvis	2C90.0		0.045	2	No

Showing 1 to 5 of 5 entries