ghrelin receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8JSR

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41594-024-01481-6

PUBLICATION DATE

Jan. 22, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

47 interactions (Click to see)

LIGANDS

anamorelin - Agonist pubchem gtoplig chembl_ligand drugbank pubchem

PHYSIOLOGICAL LIGANDS

[des-Gln14]ghrelin (Mouse), liver enriched antimicrobial peptide 2 (Human), ghrelin (Mouse), [des-Gln14]ghrelin (Human), ghrelin (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 148 34x50 G.H5 L 351 G.H5.16
Hydrophobic TM6 L 265 6x37 G.H5 L 360 G.H5.25
Van-der-waals TM6 L 265 6x37 G.H5 L 360 G.H5.25
Polar TM3 A 144 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 A 144 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM5 K 238 5x64 G.H5 L 351 G.H5.16
Polar ICL2 V 153 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 153 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 V 153 34x55 G.hns1 R 32 G.hns1.03
Polar TM3 R 141 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 141 3x50 G.H5 Y 358 G.H5.23
Polar TM2 T 78 2x39 G.H5 N 359 G.H5.24
Hydrophobic ICL2 P 148 34x50 G.H5 I 350 G.H5.15
Hydrophobic TM5 L 239 5x65 G.H5 L 355 G.H5.20
Polar TM6 T 261 6x33 G.H5 V 361 G.H5.26
Hydrophobic TM6 T 261 6x33 G.H5 V 361 G.H5.26
Van-der-waals TM6 T 261 6x33 G.H5 V 361 G.H5.26
Hydrophobic TM6 T 261 6x33 G.H5 L 355 G.H5.20
Hydrophobic ICL2 K 152 34x54 G.S1 L 34 G.S1.02
Van-der-waals ICL2 K 152 34x54 G.S1 L 34 G.S1.02
Polar ICL4 S 327 - G.H5 N 359 G.H5.24
Hydrophobic ICL4 S 327 - G.H5 N 359 G.H5.24
Van-der-waals ICL4 S 327 - G.H5 N 359 G.H5.24
Polar TM3 E 140 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM3 E 140 3x49 G.H5 Y 358 G.H5.23
Van-der-waals TM3 E 140 3x49 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 L 149 34x51 G.H5 F 343 G.H5.08
Van-der-waals ICL2 L 149 34x51 G.H5 F 343 G.H5.08
Hydrophobic TM4 T 156 4x38 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 T 156 4x38 G.hns1 R 31 G.hns1.02
Hydrophobic ICL4 M 326 - G.H5 V 361 G.H5.26
Van-der-waals ICL4 M 326 - G.H5 V 361 G.H5.26
Polar TM3 R 141 3x50 G.H5 N 359 G.H5.24
Hydrophobic ICL3 H 258 - G.H5 L 355 G.H5.20
Hydrophobic TM2 T 78 2x39 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 L 149 34x51 G.H5 I 350 G.H5.15
Van-der-waals ICL2 L 149 34x51 G.H5 I 350 G.H5.15
Hydrophobic TM3 I 145 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 I 145 3x54 G.H5 L 355 G.H5.20
Hydrophobic ICL2 L 149 34x51 G.S3 V 194 G.S3.01
Hydrophobic TM3 I 145 3x54 G.H5 L 360 G.H5.25
Van-der-waals TM3 I 145 3x54 G.H5 L 360 G.H5.25
Hydrophobic TM3 R 141 3x50 G.H5 L 360 G.H5.25
Ionic ICL3 R 241 - G.H5 D 348 G.H5.13
Polar ICL3 R 241 - G.H5 D 348 G.H5.13
Hydrophobic ICL2 L 149 34x51 G.H5 K 347 G.H5.12
Hydrophobic TM6 T 261 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM2 L 82 2x43 G.H5 N 359 G.H5.24
Hydrophobic ICL2 K 152 34x54 G.H5 I 350 G.H5.15
Hydrophobic TM3 A 144 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 A 144 3x53 G.H5 Y 358 G.H5.23
Hydrophobic TM3 I 145 3x54 G.H5 L 351 G.H5.16
Van-der-waals TM3 I 145 3x54 G.H5 L 351 G.H5.16
Van-der-waals ICL4 M 326 - G.H5 L 360 G.H5.25