PDB
8JSR
Resolution
2.9 Å
Released
Jan. 22, 2025
Receptor
ghrelin
Class
A
Species
Homo sapiens
Ligand
anamorelin
Function
Agonist
Reference
10.1038/S41594-024-01481-6

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Ligand Amino Acid Generic Number Segment Interaction Type
anamorelin R102 2.63x63 TM2 polar (charge-assisted hydrogen bond)
anamorelin L103 2.64x64 TM2 hydrophobic
anamorelin L103 2.64x64 TM2 Van der Waals
anamorelin Q120 3.29x29 TM3 Van der Waals
anamorelin S123 3.32x32 TM3 polar (hydrogen bond)
anamorelin S123 3.32x32 TM3 Van der Waals
anamorelin E124 3.33x33 TM3 polar (charge-assisted hydrogen bond)
anamorelin L181 4.63x64 TM4 hydrophobic
anamorelin L210 5.36x36 TM5 Van der Waals
anamorelin L210 5.36x36 TM5 hydrophobic
anamorelin M213 5.39x39 TM5 Van der Waals
anamorelin M213 5.39x39 TM5 hydrophobic
anamorelin V214 5.40x40 TM5 hydrophobic
anamorelin V214 5.40x40 TM5 Van der Waals
anamorelin R283 6.55x55 TM6 Van der Waals
anamorelin F286 6.58x58 TM6 hydrophobic
anamorelin F286 6.58x58 TM6 Van der Waals
anamorelin N305 7.35x34 TM7 Van der Waals
anamorelin F309 7.39x38 TM7 aromatic (face-to-edge)
anamorelin F309 7.39x38 TM7 Van der Waals
anamorelin F312 7.42x41 TM7 hydrophobic
anamorelin F312 7.42x41 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R E L R ICL1ECL1 R P W N F ECL1ICL2 P L R A K V V V ICL2ECL2 G V E H E N G T D P W D T N E C R P T E F A V R S ECL2ICL3 A V V G A ICL3ECL3 P G S ECL3N-term M W N A T P S E E P G F N L T L A D L D W D A S P G N D S L G D E L L Q L F N-termC-term F S Q R K L S T L K D E S S R A W T E S S I N T C-term P A P L L A G V T A T C V A L F V V G I A G N L L T M L V V S R F T T T N L Y L S S M A F S D L L I F L C M P L D L V R L W Q Y G D L L C K L F Q F V S E S C T Y A T V L T I T A L S V E R Y F A I C F T K G R V K L V I F V I W A V A F C S A G P I F V L V G L L T V M V W V S S I F F F L P V F C L T V L Y S L I G R K L W R R R R G D S L R D Q N H K Q T V K M L A V V V F A F I L C W L P F H V G R Y L F S K S F E L E I A Q I S Q Y C N L V S F V L F Y L S A A I N P I L Y N I M S K K V F R E P Y R V A L L G F
Helix box plot — Download: PNG | SVG L N G A I G V V F L A V C T A T V G A L 1 S S M A F S D L L I F L C M P L D L V R 2 A T I T L V T A Y T C S E S V F Q F L K 3 V K L V I F V I W A V A F C S A G P I 4 Y L V T L C F V P L F F F I S S V W V M 5 A V V V F A F I L C W L P F H V G R Y L 6 I P N I A A S L Y F L V F S V L N C Y 7

GPCRdb(A)
GPCRdb(A)
ghrelin receptor
TM2
2x63 2.63x63 R102
2x64 2.64x64 L103
TM3
3x29 3.29x29 Q120
3x32 3.32x32 S123
3x33 3.33x33 E124
TM4
4x64 4.63x64 L181
TM5
5x36 5.36x36 L210
5x39 5.39x39 M213
5x40 5.40x40 V214
TM6
6x55 6.55x55 R283
6x58 6.58x58 F286
TM7
7x34 7.35x34 N305
7x38 7.39x38 F309
7x41 7.42x41 F312