ghrelin receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7NA8

RESOLUTION

2.7 Å

REFERENCE

10.1038/S41467-021-26735-5

PUBLICATION DATE

Dec. 15, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

48 interactions (Click to see)

LIGANDS

ibutamoren - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

[des-Gln14]ghrelin, ghrelin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 148 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 148 34x50 G.H5 I 343 G.H5.15
Polar ICL1 T 76 - G.H5 D 350 G.H5.22
Hydrophobic ICL1 T 76 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 T 76 - G.H5 D 350 G.H5.22
Hydrophobic TM6 N 257 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 N 257 6x29 G.H5 F 354 G.H5.26
Polar TM2 T 78 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 78 2x39 G.H5 D 350 G.H5.22
Ionic TM5 R 242 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 242 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 242 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM3 R 141 3x50 G.H5 L 353 G.H5.25
Polar ICL2 K 152 34x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 M 264 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 R 242 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 242 5x68 G.H5 I 344 G.H5.16
Polar TM3 R 141 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 141 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 T 261 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 K 152 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 152 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 A 144 3x53 G.H5 C 351 G.H5.23
Hydrophobic H8 S 327 8x47 G.H5 G 352 G.H5.24
Ionic H8 K 329 8x49 G.H5 D 350 G.H5.22
Polar H8 K 329 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 148 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL2 T 156 - G.HN E 28 G.HN.52
Van-der-waals ICL2 T 156 - G.HN E 28 G.HN.52
Hydrophobic TM3 I 145 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 145 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 149 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 149 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 K 152 34x54 G.H5 I 343 G.H5.15
Polar TM4 G 158 4x40 G.HN E 28 G.HN.52
Polar ICL2 V 153 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 153 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 148 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 148 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 K 238 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM6 H 258 6x30 G.H5 L 348 G.H5.20
Polar TM2 T 78 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 78 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 145 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 145 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 149 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 149 34x51 G.H5 I 343 G.H5.15
Polar TM3 A 144 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 144 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 144 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 149 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 149 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM6 T 261 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 261 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 149 34x51 G.H5 T 340 G.H5.12