Structure information

ghrelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7NA8

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-021-26735-5

PUBLICATION DATE

Dec. 15, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ibutamoren D99 2.60x60 TM2 polar (charge-assisted hydrogen bond)
ibutamoren R102 2.63x63 TM2 polar (charge-assisted hydrogen bond)
ibutamoren L103 2.64x64 TM2 Van der Waals
ibutamoren Q120 3.29x29 TM3 Van der Waals
ibutamoren Q120 3.29x29 TM3 polar (hydrogen bond)
ibutamoren E124 3.33x33 TM3 Van der Waals
ibutamoren L210 5.36x36 TM5 hydrophobic
ibutamoren L210 5.36x36 TM5 Van der Waals
ibutamoren M213 5.39x39 TM5 hydrophobic
ibutamoren M213 5.39x39 TM5 Van der Waals
ibutamoren V214 5.40x40 TM5 hydrophobic
ibutamoren V214 5.40x40 TM5 Van der Waals
ibutamoren S217 5.43x43 TM5 Van der Waals
ibutamoren F279 6.51x51 TM6 Van der Waals
ibutamoren R283 6.55x55 TM6 polar (charge-assisted hydrogen bond)
ibutamoren F286 6.58x58 TM6 hydrophobic
ibutamoren F286 6.58x58 TM6 Van der Waals
ibutamoren Q302 7.32x31 TM7 Van der Waals
ibutamoren N305 7.35x34 TM7 polar (hydrogen bond with backbone)
ibutamoren N305 7.35x34 TM7 Van der Waals
ibutamoren L306 7.36x35 TM7 Van der Waals
ibutamoren F309 7.39x38 TM7 Van der Waals
ibutamoren F312 7.42x41 TM7 hydrophobic

Ligands

ibutamoren

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Residue Diagrams

L N G A I G V V F L A V C T A T V G A L 1 S S M A F S D L L I F L C M P L D L V R 2 A T I T L V T A Y T C S E S V F Q F L K 3 V K L V I F V I W A V A F C S A G P I 4 Y L V T L C F V P L F F F I S S V W V M 5 A V V V F A F I L C W L P F H V G R Y L 6 I P N I A A S L Y F L V F S V L N C Y 7
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ICL1 R E L R ICL1ECL1 R P W N F ECL1ICL2 P L R A K V V V ICL2ECL2 G V E H E N G T D P W D T N E C R P T E F A V R S ECL2ICL3 A V V G A ICL3ECL3 P G S ECL3N-term M W N A T P S E E P G F N L T L A D L D W D A S P G N D S L G D E L L Q L F N-termC-term F S Q R K L S T L K D E S S R A W T E S S I N T C-term P A P L L A G V T A T C V A L F V V G I A G N L L T M L V V S R F T T T N L Y L S S M A F S D L L I F L C M P L D L V R L W Q Y G D L L C K L F Q F V S E S C T Y A T V L T I T A L S V E R Y F A I C F T K G R V K L V I F V I W A V A F C S A G P I F V L V G L L T V M V W V S S I F F F L P V F C L T V L Y S L I G R K L W R R R R G D S L R D Q N H K Q T V K M L A V V V F A F I L C W L P F H V G R Y L F S K S F E L E I A Q I S Q Y C N L V S F V L F Y L S A A I N P I L Y N I M S K K V F R E P Y R V A L L G F
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Residue Table


GPCRdb(A)
GPCRdb(A)
ghrelin receptor
TM2
2x60 2.60x60 D99
2x63 2.63x63 R102
2x64 2.64x64 L103
TM3
3x29 3.29x29 Q120
3x33 3.33x33 E124
TM5
5x36 5.36x36 L210
5x39 5.39x39 M213
5x40 5.40x40 V214
5x43 5.43x43 S217
TM6
6x51 6.51x51 F279
6x55 6.55x55 R283
6x58 6.58x58 F286
TM7
7x31 7.32x31 Q302
7x34 7.35x34 N305
7x35 7.36x35 L306
7x38 7.39x38 F309
7x41 7.42x41 F312