Structure information

ghrelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7NA8

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

R

PUBLICATION DATE

Dec. 15, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ibutamoren D99 2.60x60 TM2 polar (charge-charge)
ibutamoren R102 2.63x63 TM2 polar (charge-assisted hydrogen bond)
ibutamoren Q120 3.29x29 TM3 polar (hydrogen bond)
ibutamoren Q120 3.29x29 TM3 polar (hydrogen bond)
ibutamoren L210 5.36x36 TM5 hydrophobic
ibutamoren M213 5.39x39 TM5 hydrophobic
ibutamoren V214 5.40x40 TM5 hydrophobic
ibutamoren R283 6.55x55 TM6 polar (charge-assisted hydrogen bond)
ibutamoren R283 6.55x55 TM6 polar (charge-assisted hydrogen bond)
ibutamoren F286 6.58x58 TM6 hydrophobic
ibutamoren N305 7.35x34 TM7 polar (hydrogen bond with backbone)

Ligands

ibutamoren

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Residue Diagrams

L N G A I G V V F L A V C T A T V G A L 1 S S M A F S D L L I F L C M P L D L V R 2 A T I T L V T A Y T C S E S V F Q F L K 3 V K L V I F V I W A V A F C S A G P I 4 Y L V T L C F V P L F F F I S S V W V M 5 A V V V F A F I L C W L P F H V G R Y L 6 I P N I A A S L Y F L V F S V L N C Y 7
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ICL1 R E L R ICL1ECL1 R P W N F ECL1ICL2 P L R A K V V V ICL2ECL2 G V E H E N G T D P W D T N E C R P T E F A V R S ECL2ICL3 A V V G A ICL3ECL3 P G S ECL3N-term M W N A T P S E E P G F N L T L A D L D W D A S P G N D S L G D E L L Q L F N-termC-term F S Q R K L S T L K D E S S R A W T E S S I N T C-term P A P L L A G V T A T C V A L F V V G I A G N L L T M L V V S R F T T T N L Y L S S M A F S D L L I F L C M P L D L V R L W Q Y G D L L C K L F Q F V S E S C T Y A T V L T I T A L S V E R Y F A I C F T K G R V K L V I F V I W A V A F C S A G P I F V L V G L L T V M V W V S S I F F F L P V F C L T V L Y S L I G R K L W R R R R G D S L R D Q N H K Q T V K M L A V V V F A F I L C W L P F H V G R Y L F S K S F E L E I A Q I S Q Y C N L V S F V L F Y L S A A I N P I L Y N I M S K K V F R E P Y R V A L L G F
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Residue Table


GPCRdb(A)
GPCRdb(A)
ghrelin receptor
TM2
2x60 2.60x60 D99
2x63 2.63x63 R102
TM3
3x29 3.29x29 Q120
TM5
5x36 5.36x36 L210
5x39 5.39x39 M213
5x40 5.40x40 V214
TM6
6x55 6.55x55 R283
6x58 6.58x58 F286
TM7
7x34 7.35x34 N305