TA1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Nov. 15, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

CHEMBL1182312 - Agonist chembl_ligand chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

octopamine, β-phenylethylamine, CHEMBL1160703, tyramine, (+)-Octopamine, 3-iodothyronamine, dopamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 A 217 5x65 G.H5 L 393 G.H5.25
Van-der-waals TM5 A 217 5x65 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 128 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 128 - G.H5 I 383 G.H5.15
Aromatic ICL2 Y 131 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 131 - G.H5 H 387 G.H5.19
Ionic TM6 K 248 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 248 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 248 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 248 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM5 I 213 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 213 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 A 221 5x69 G.H5 L 394 G.H5.26
Aromatic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 224 5x72 G.H5 L 394 G.H5.26
Polar TM5 Q 220 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 220 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 129 - G.H5 R 380 G.H5.12
Polar ICL2 R 130 - G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 130 - G.s2s3 D 215 G.s2s3.01
Polar TM6 T 252 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM5 Q 220 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM3 V 125 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 125 3x54 G.H5 L 388 G.H5.20
Polar TM5 Q 220 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 220 5x68 G.H5 R 385 G.H5.17
Ionic TM5 K 230 5x78 G.hgh4 D 323 G.hgh4.13
Polar TM5 K 230 5x78 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 K 230 5x78 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 K 230 5x78 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 Q 220 5x68 G.H5 L 394 G.H5.26
Ionic TM3 D 127 3x56 G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 128 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 128 - G.H5 R 380 G.H5.12
Hydrophobic TM3 V 125 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 V 125 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 253 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 128 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 128 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 R 130 - G.S3 V 217 G.S3.01
Hydrophobic TM5 I 224 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 224 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 129 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 129 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 L 129 - G.S1 H 41 G.S1.02
Hydrophobic TM5 I 216 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM3 A 124 3x53 G.H5 Y 391 G.H5.23
Polar ICL2 Y 131 - G.H5 Y 391 G.H5.23
Polar TM3 A 124 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 129 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 129 - G.H5 I 383 G.H5.15
Hydrophobic TM5 I 216 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 I 216 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 A 217 5x65 G.H5 L 388 G.H5.20
Polar TM5 Q 220 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 I 224 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 A 249 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 231 5x79 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 L 231 5x79 G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 P 128 - G.H5 H 387 G.H5.19
Hydrophobic TM6 K 248 6x32 G.H5 L 394 G.H5.26
Hydrophobic H8 P 309 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 P 309 8x48 G.H5 E 392 G.H5.24