NTS1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6OS9

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41586-019-1337-6

PUBLICATION DATE

July 10, 2019

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

53 interactions (Click to see)

LIGANDS

JMV449 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

large neuromedin N, neuromedin N, neurotensin, large neurotensin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 V 304 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 169 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 173 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM4 S 181 4x38 G.HN E 28 G.HN.52
Hydrophobic TM5 M 266 5x68 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 263 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 I 259 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 174 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 F 174 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 P 173 34x50 G.H5 I 343 G.H5.15
Polar TM4 R 182 4x39 G.HN E 28 G.HN.52
Hydrophobic TM6 A 297 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 297 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 170 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 170 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 298 6x30 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 298 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 305 6x37 G.H5 L 353 G.H5.25
Polar TM3 A 169 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 169 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 169 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 166 3x50 G.H5 L 353 G.H5.25
Polar TM3 R 166 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 166 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 166 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM4 S 181 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 S 181 4x38 G.hns1 R 32 G.hns1.03
Polar ICL2 T 178 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 178 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM2 V 101 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 Q 98 2x36 G.H5 D 350 G.H5.22
Van-der-waals TM2 Q 98 2x36 G.H5 D 350 G.H5.22
Van-der-waals ICL2 K 177 34x54 G.S1 V 34 G.S1.02
Hydrophobic ICL2 F 174 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 174 34x51 G.H5 T 340 G.H5.12
Polar ICL2 M 180 34x57 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 M 180 34x57 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 177 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 177 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 178 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 T 178 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM2 V 101 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 101 2x39 G.H5 C 351 G.H5.23
Polar TM6 G 301 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 G 301 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 K 177 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL4 S 368 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 K 177 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 K 177 34x54 G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 173 34x50 G.H5 T 340 G.H5.12
Polar TM4 S 183 4x40 G.HN E 28 G.HN.52
Hydrophobic TM5 M 266 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 170 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 170 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 T 178 34x55 G.S3 L 194 G.S3.01
Hydrophobic ICL4 S 368 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 S 368 - G.H5 G 352 G.H5.24
Hydrophobic ICL2 F 174 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 174 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 F 174 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 174 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM6 L 298 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM2 L 97 2x35 G.H5 N 347 G.H5.19
Van-der-waals TM2 L 97 2x35 G.H5 N 347 G.H5.19