C5a1 receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

Nov. 26, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

EP67 - Agonist

PHYSIOLOGICAL LIGANDS

C5a des-Arg (Human), C5a (Rat), C3a (Mouse), C5a (Mouse), ribosomal protein S19 (Human), C3a (Human), C5a (Human), C3a (Rat)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic ICL2 I 142 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM3 L 137 3x53 G.H5 N 347 G.H5.19
Polar TM6 T 240 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 240 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 240 6x33 G.H5 L 353 G.H5.25
Polar ICL4 Q 305 - G.H5 R 349 G.H5.21
Van-der-waals ICL4 Q 305 - G.H5 R 349 G.H5.21
Polar TM3 R 134 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 134 3x50 G.H5 C 351 G.H5.23
Polar ICL2 N 146 34x55 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 N 146 34x55 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 P 141 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 K 239 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 243 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 142 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 Q 145 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 Q 145 34x54 G.hns1 K 32 G.hns1.03
Polar ICL2 N 146 34x55 G.hns1 K 32 G.hns1.03
Polar TM6 K 239 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 239 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 239 6x32 G.H5 Y 354 G.H5.26
Polar ICL3 S 237 - G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 141 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 138 3x54 G.H5 L 348 G.H5.20
Ionic ICL3 R 232 - G.H5 D 341 G.H5.13
Polar ICL3 R 232 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 232 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 232 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 I 142 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL3 T 235 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 S 237 - G.H5 Y 354 G.H5.26
Van-der-waals ICL3 S 237 - G.H5 Y 354 G.H5.26
Van-der-waals ICL2 Q 145 34x54 G.S3 L 195 G.S3.01
Polar ICL3 T 235 - G.H5 Y 354 G.H5.26
Hydrophobic ICL3 T 235 - G.H5 Y 354 G.H5.26
Van-der-waals ICL3 T 235 - G.H5 Y 354 G.H5.26
Hydrophobic TM5 T 229 5x65 G.H5 L 348 G.H5.20