PDB
9KUG
Resolution
3.1 Å
Released
Nov. 26, 2025
Receptor
C5a1
Class
A
Species
Homo sapiens
Ligand
EP67
Function
Agonist
Reference
10.1073/PNAS.2614459123

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Ligand Amino Acid Generic Number Segment Interaction Type
EP67 L92 2.60x60 TM2 hydrophobic
EP67 W102 23.50x50 ECL1 hydrophobic
EP67 L117 3.33x33 TM3 hydrophobic
EP67 R175 ECL2 polar (charge-assisted hydrogen bond)
EP67 R178 ECL2 Van der Waals
EP67 L187 ECL2 Van der Waals
EP67 L187 ECL2 hydrophobic
EP67 C188 45.50x50 ECL2 Van der Waals
EP67 C188 45.50x50 ECL2 polar (hydrogen bond with backbone)
EP67 G189 45.51x51 ECL2 Van der Waals
EP67 V190 45.52x52 ECL2 hydrophobic
EP67 V190 45.52x52 ECL2 Van der Waals
EP67 D191 ECL2 polar (charge-assisted hydrogen bond)
EP67 Y192 ECL2 Van der Waals
EP67 E199 5.35x36 TM5 polar (charge-assisted hydrogen bond)
EP67 Y258 6.51x51 TM6 hydrophobic
EP67 Y258 6.51x51 TM6 Van der Waals
EP67 T261 6.54x54 TM6 Van der Waals
EP67 G262 6.55x55 TM6 Van der Waals
EP67 K279 7.32x31 TM7 polar (charge-assisted hydrogen bond)
EP67 D282 7.35x34 TM7 polar (charge-assisted hydrogen bond)
EP67 Y290 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 A K R ICL1ECL1 H H W P F ECL1ICL2 P I W C Q N F R ICL2ECL2 V V R E E Y F P P K V L C G V D Y S H ECL2ICL3 R A T R S ICL3ECL3 E P S ECL3N-term M D S F N Y T T P D Y G H Y D D K D T L D L N T P V D K T S N T L N-termC-term L P S L L R N V L T E E S V V R E S K S F T R S T V D T M A Q K T Q A V C-term R V P D I L A L V I F A V V F L V G V L G N A L V V W V T A F E T I N A I W F L N L A V A D F L S C L A L P I L F T S I V Q H G G A A C S I L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K G A G L A W I A C A V A W G L A L L L T I P S F L Y R D K R R E R A V A I V R L V L G F L W P L L T L T I C Y T F I L L R T W S R T K T L K V V V A V V A S F F I F W L P Y Q V T G I M M S F L S P T F L L L K K L D S L C V S F A Y I N C C I N P I I Y V V A G Q G F R K S Q G R L
Helix box plot — Download: PNG | SVG A N G L V G V L F V V A F I V L A L I D 1 L N L A V A D F L S C L A L P I L F T S 2 T A L L L I S A Y M N L L I L S P L I S 3 A W I A C A V A W G L A L L L T I P S 4 Y C I T L T L L P W L F G L V L R V I A V 5 V A V V A S F F I F W L P Y Q V T G I M 6 I P N I C C N I Y A F S V C L S D L K 7

GPCRdb(A)
GPCRdb(A)
C5a1 receptor
TM2
2x60 2.60x60 L92
ECL1
23x50 23.50x50 W102
TM3
3x33 3.33x33 L117
ECL2
45x50 45.50x50 C188
45x51 45.51x51 G189
45x52 45.52x52 V190
TM5
5x36 5.35x36 E199
TM6
6x51 6.51x51 Y258
6x54 6.54x54 T261
6x55 6.55x55 G262
TM7
7x31 7.32x31 K279
7x34 7.35x34 D282
7x42 7.43x42 Y290