ghrelin receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

Jan. 19, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Ghrelin - Agonist pubchem

PHYSIOLOGICAL LIGANDS

[des-Gln14]ghrelin, ghrelin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM6 R 254 6x26 G.S6 Y 320 G.S6.02
Hydrophobic TM5 L 239 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 148 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 L 149 - G.H5 F 336 G.H5.08
Ionic TM5 R 242 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 242 5x68 G.H5 D 341 G.H5.13
Hydrophobic H8 K 328 8x48 G.H5 R 349 G.H5.21
Hydrophobic TM6 H 258 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 253 6x25 G.h4s6 P 315 G.h4s6.09
Hydrophobic ICL2 L 149 - G.S3 L 195 G.S3.01
Polar TM3 A 144 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 144 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 144 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 145 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM5 R 242 5x68 G.H5 I 344 G.H5.16
Polar TM3 R 141 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 141 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 T 261 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM7 M 326 7x56 G.H5 Y 354 G.H5.26
Van-der-waals TM7 M 326 7x56 G.H5 Y 354 G.H5.26
Hydrophobic TM6 T 261 6x33 G.H5 L 348 G.H5.20
Polar H8 K 328 8x48 G.H5 Y 354 G.H5.26
Hydrophobic H8 K 328 8x48 G.H5 Y 354 G.H5.26
Van-der-waals H8 K 328 8x48 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 P 148 - G.H5 I 343 G.H5.15
Polar TM6 N 257 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 N 257 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 N 257 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM3 I 145 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 264 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 145 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 145 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 149 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 149 - G.H5 I 343 G.H5.15
Ionic ICL3 R 243 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 P 148 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 148 - G.H5 I 344 G.H5.16
Hydrophobic TM2 T 78 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 A 144 3x53 G.H5 C 351 G.H5.23
Ionic TM6 R 254 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM5 K 238 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM3 R 141 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 265 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 265 6x37 G.H5 L 353 G.H5.25
Ionic TM6 R 254 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic H8 S 327 8x47 G.H5 G 352 G.H5.24