Refined structure (8F7X) of Gi1 - NOP receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 221 from structure (62.4%), 133 from model (37.6%)
Residue sidechains - 219 from structure (61.9%), 135 from model (38.1%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 285 from structure (82.6%), 60 from model (17.4%)
Residue sidechains - 285 from structure (82.6%), 60 from model (17.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 L - AF2 AF2
N-term 5 F - AF2 AF2
N-term 6 P - AF2 AF2
N-term 7 A - AF2 AF2
N-term 8 P - AF2 AF2
N-term 9 F - AF2 AF2
N-term 10 W - AF2 AF2
N-term 11 E - AF2 AF2
N-term 12 V - AF2 AF2
N-term 13 I - AF2 AF2
N-term 14 Y - AF2 AF2
N-term 15 G - AF2 AF2
N-term 16 S - AF2 AF2
N-term 17 H - AF2 AF2
N-term 18 L - AF2 AF2
N-term 19 Q - AF2 AF2
N-term 20 G - AF2 AF2
N-term 21 N - AF2 AF2
N-term 22 L - AF2 AF2
N-term 23 S - AF2 AF2
N-term 24 L - AF2 AF2
N-term 25 L - AF2 AF2
N-term 26 S - AF2 AF2
N-term 27 P - AF2 AF2
N-term 28 N - AF2 AF2
N-term 29 H - AF2 AF2
N-term 30 S - AF2 AF2
N-term 31 L - AF2 AF2
N-term 32 L - AF2 AF2
N-term 33 P - AF2 AF2
N-term 34 P - AF2 AF2
N-term 35 H - AF2 AF2
N-term 36 L - AF2 AF2
N-term 37 L - AF2 AF2
N-term 38 L - AF2 AF2
N-term 39 N - AF2 AF2
N-term 40 A - AF2 AF2
N-term 41 S - AF2 AF2
N-term 42 H - AF2 AF2
N-term 43 G - AF2 AF2
N-term 44 A - AF2 AF2
N-term 45 F - AF2 AF2
N-term 46 L - AF2 AF2
N-term 47 P - AF2 AF2
TM1 48 L 1.29x29 AF2 AF2
TM1 49 G 1.30x30 Structure Structure
TM1 50 L 1.31x31 Structure Structure
TM1 51 K 1.32x32 Structure Structure
TM1 52 V 1.33x33 Structure Structure
TM1 53 T 1.34x34 Structure Structure
TM1 54 I 1.35x35 Structure Structure
TM1 55 V 1.36x36 Structure Structure
TM1 56 G 1.37x37 Structure Structure
TM1 57 L 1.38x38 Structure Structure
TM1 58 Y 1.39x39 Structure Structure
TM1 59 L 1.40x40 Structure Structure
TM1 60 A 1.41x41 Structure Structure
TM1 61 V 1.42x42 Structure Structure
TM1 62 C 1.43x43 Structure Structure
TM1 63 V 1.44x44 Structure Structure
TM1 64 G 1.45x45 Structure Structure
TM1 65 G 1.46x46 Structure Structure
TM1 66 L 1.47x47 Structure Structure
TM1 67 L 1.48x48 Structure Structure
TM1 68 G 1.49x49 Structure Structure
TM1 69 N 1.50x50 Structure Structure
TM1 70 C 1.51x51 Structure Structure
TM1 71 L 1.52x52 Structure Structure
TM1 72 V 1.53x53 Structure Structure
TM1 73 M 1.54x54 Structure Structure
TM1 74 Y 1.55x55 Structure Structure
TM1 75 V 1.56x56 Structure Structure
TM1 76 I 1.57x57 Structure Structure
TM1 77 L 1.58x58 Structure Structure
TM1 78 R 1.59x59 Structure Structure
TM1 79 H 1.60x60 Structure Structure
ICL1 80 T 12.48x48 Structure Structure
ICL1 81 K 12.49x49 Structure Structure
ICL1 82 M 12.50x50 Structure Structure
ICL1 83 K 12.51x51 Structure Structure
TM2 84 T 2.37x37 Structure Structure
TM2 85 A 2.38x38 Structure Structure
TM2 86 T 2.39x39 Structure Structure
TM2 87 N 2.40x40 Structure Structure
TM2 88 I 2.41x41 Structure Structure
TM2 89 Y 2.42x42 Structure Structure
TM2 90 I 2.43x43 Structure Structure
TM2 91 F 2.44x44 Structure Structure
TM2 92 N 2.45x45 Structure Structure
TM2 93 L 2.46x46 Structure Structure
TM2 94 A 2.47x47 Structure Structure
TM2 95 L 2.48x48 Structure Structure
TM2 96 A 2.49x49 Structure Structure
TM2 97 D 2.50x50 Structure Structure
TM2 98 T 2.51x51 Structure Structure
TM2 99 L 2.52x52 Structure Structure
TM2 100 V 2.53x53 Structure Structure
TM2 101 L 2.54x54 Structure Structure
TM2 102 L 2.55x55 Structure Structure
TM2 103 T 2.56x56 Structure Structure
TM2 104 L 2.57x57 Structure Structure
TM2 105 P 2.58x58 Structure Structure
TM2 106 F 2.59x59 Structure Structure
TM2 107 Q 2.60x60 Structure Structure
TM2 108 G 2.61x61 Structure Structure
TM2 109 T 2.62x62 Structure Structure
TM2 110 D 2.63x63 Structure Structure
TM2 111 I 2.64x64 Structure Structure
TM2 112 L 2.65x65 Structure Structure
TM2 113 L 2.66x66 Structure Structure
TM2 114 G 2.67x67 Structure Structure
ECL1 115 F 23.49x49 Structure Structure
ECL1 116 W 23.50x50 Structure Structure
ECL1 117 P 23.51x51 Structure Structure
ECL1 118 F 23.52x52 Structure Structure
TM3 119 G 3.21x21 Structure Structure
TM3 120 N 3.22x22 Structure Structure
TM3 121 A 3.23x23 Structure Structure
TM3 122 L 3.24x24 Structure Structure
TM3 123 C 3.25x25 Structure Structure
TM3 124 K 3.26x26 Structure Structure
TM3 125 T 3.27x27 Structure Structure
TM3 126 V 3.28x28 Structure Structure
TM3 127 I 3.29x29 Structure Structure
TM3 128 A 3.30x30 Structure Structure
TM3 129 I 3.31x31 Structure Structure
TM3 130 D 3.32x32 Structure Structure
TM3 131 Y 3.33x33 Structure Structure
TM3 132 Y 3.34x34 Structure Structure
TM3 133 N 3.35x35 Structure Structure
TM3 134 M 3.36x36 Structure Structure
TM3 135 F 3.37x37 Structure Structure
TM3 136 T 3.38x38 Structure Structure
TM3 137 S 3.39x39 Structure Structure
TM3 138 T 3.40x40 Structure Structure
TM3 139 F 3.41x41 Structure Structure
TM3 140 T 3.42x42 Structure Structure
TM3 141 L 3.43x43 Structure Structure
TM3 142 T 3.44x44 Structure Structure
TM3 143 A 3.45x45 Structure Structure
TM3 144 M 3.46x46 Structure Structure
TM3 145 S 3.47x47 Structure Structure
TM3 146 V 3.48x48 Structure Structure
TM3 147 D 3.49x49 Structure Structure
TM3 148 R 3.50x50 Structure Structure
TM3 149 Y 3.51x51 Structure Structure
TM3 150 V 3.52x52 Structure Structure
TM3 151 A 3.53x53 Structure Structure
TM3 152 I 3.54x54 Structure Structure
TM3 153 C 3.55x55 Structure Structure
TM3 154 H 3.56x56 Structure Structure
ICL2 155 P 34.50x50 Structure Structure
ICL2 156 I 34.51x51 Structure Structure
ICL2 157 R 34.52x52 Structure Structure
ICL2 158 A 34.53x53 Structure Structure
ICL2 159 L 34.54x54 Structure Structure
ICL2 160 D 34.55x55 Structure Structure
ICL2 161 V 34.56x56 Structure Structure
ICL2 162 R 34.57x57 Structure Structure
TM4 163 T 4.38x38 Structure Structure
TM4 164 S 4.39x39 Structure Structure
TM4 165 S 4.40x40 Structure Structure
TM4 166 K 4.41x41 Structure Structure
TM4 167 A 4.42x42 Structure Structure
TM4 168 Q 4.43x43 Structure Structure
TM4 169 A 4.44x44 Structure Structure
TM4 170 V 4.45x45 Structure Structure
TM4 171 N 4.46x46 Structure Structure
TM4 172 V 4.47x47 Structure Structure
TM4 173 A 4.48x48 Structure Structure
TM4 174 I 4.49x49 Structure Structure
TM4 175 W 4.50x50 Structure Structure
TM4 176 A 4.51x51 Structure Structure
TM4 177 L 4.52x52 Structure Structure
TM4 178 A 4.53x53 Structure Structure
TM4 179 S 4.54x54 Structure Structure
TM4 180 V 4.55x55 Structure Structure
TM4 181 V 4.56x56 Structure Structure
TM4 182 G 4.57x57 Structure Structure
TM4 183 V 4.58x58 Structure Structure
TM4 184 P 4.59x59 Structure Structure
TM4 185 V 4.60x60 Structure Structure
TM4 186 A 4.61x61 Structure Structure
TM4 187 I 4.62x62 Structure Structure
TM4 188 M 4.63x63 Structure Structure
TM4 189 G 4.64x64 Structure Structure
ECL2 190 S - Structure Structure
ECL2 191 A - Structure Structure
ECL2 192 Q - Structure Structure
ECL2 193 V - Structure Structure
ECL2 194 E - Structure Structure
ECL2 195 D - Structure Structure
ECL2 196 E - Structure Structure
ECL2 197 E - Structure Structure
ECL2 198 I - Structure Structure
ECL2 199 E - Structure Structure
ECL2 200 C 45.50x50 Structure Structure
ECL2 201 L 45.51x51 Structure Structure
ECL2 202 V 45.52x52 Structure Structure
ECL2 203 E - Structure Structure
ECL2 204 I - Structure Structure
ECL2 205 P - Structure Structure
ECL2 206 T - Structure Structure
TM5 207 P 5.30x31 Structure Structure
TM5 208 Q 5.31x32 Structure Structure
TM5 209 D 5.32x33 Structure Structure
TM5 210 Y 5.33x34 Structure Structure
TM5 211 W 5.34x35 Structure Structure
TM5 212 G 5.35x36 Structure Structure
TM5 213 P 5.36x37 Structure Structure
TM5 214 V 5.37x38 Structure Structure
TM5 215 F 5.38x39 Structure Structure
TM5 216 A 5.39x40 Structure Structure
TM5 217 I 5.40x41 Structure Structure
TM5 218 C 5.41x42 Structure Structure
TM5 219 I 5.42x43 Structure Structure
TM5 220 F 5.43x44 Structure Structure
TM5 221 L 5.44x45 Structure Structure
TM5 222 F 5.45x46 Structure Structure
TM5 223 S 5.46x461 Structure Structure
TM5 224 F 5.47x47 Structure Structure
TM5 225 I 5.48x48 Structure Structure
TM5 226 V 5.49x49 Structure Structure
TM5 227 P 5.50x50 Structure Structure
TM5 228 V 5.51x51 Structure Structure
TM5 229 L 5.52x52 Structure Structure
TM5 230 V 5.53x53 Structure Structure
TM5 231 I 5.54x54 Structure Structure
TM5 232 S 5.55x55 Structure Structure
TM5 233 V 5.56x56 Structure Structure
TM5 234 C 5.57x57 Structure Structure
TM5 235 Y 5.58x58 Structure Structure
TM5 236 S 5.59x59 Structure Structure
TM5 237 L 5.60x60 Structure Structure
TM5 238 M 5.61x61 Structure Structure
TM5 239 I 5.62x62 Structure Structure
TM5 240 R 5.63x63 Structure Structure
TM5 241 R 5.64x64 Structure Structure
TM5 242 L 5.65x65 Structure Structure
TM5 243 R 5.66x66 Structure Structure
TM5 244 G 5.67x67 Structure Structure
TM5 245 V 5.68x68 Structure Structure
ICL3 246 R - Structure Structure
ICL3 247 L - Structure Structure
ICL3 248 L - Structure Structure
ICL3 249 S - Structure Structure
ICL3 250 G - Structure Structure
TM6 251 S 6.23x23 Structure Structure
TM6 252 R 6.24x24 Structure Structure
TM6 253 E 6.25x25 Structure Structure
TM6 254 K 6.26x26 Structure Structure
TM6 255 D 6.27x27 Structure Structure
TM6 256 R 6.28x28 Structure Structure
TM6 257 N 6.29x29 Structure Structure
TM6 258 L 6.30x30 Structure Structure
TM6 259 R 6.31x31 Structure Structure
TM6 260 R 6.32x32 Structure Structure
TM6 261 I 6.33x33 Structure Structure
TM6 262 T 6.34x34 Structure Structure
TM6 263 R 6.35x35 Structure Structure
TM6 264 L 6.36x36 Structure Structure
TM6 265 V 6.37x37 Structure Structure
TM6 266 L 6.38x38 Structure Structure
TM6 267 V 6.39x39 Structure Structure
TM6 268 V 6.40x40 Structure Structure
TM6 269 V 6.41x41 Structure Structure
TM6 270 A 6.42x42 Structure Structure
TM6 271 V 6.43x43 Structure Structure
TM6 272 F 6.44x44 Structure Structure
TM6 273 V 6.45x45 Structure Structure
TM6 274 G 6.46x46 Structure Structure
TM6 275 C 6.47x47 Structure Structure
TM6 276 W 6.48x48 Structure Structure
TM6 277 T 6.49x49 Structure Structure
TM6 278 P 6.50x50 Structure Structure
TM6 279 V 6.51x51 Structure Structure
TM6 280 Q 6.52x52 Structure Structure
TM6 281 V 6.53x53 Structure Structure
TM6 282 F 6.54x54 Structure Structure
TM6 283 V 6.55x55 Structure Structure
TM6 284 L 6.56x56 Structure Structure
TM6 285 A 6.57x57 Structure Structure
TM6 286 Q 6.58x58 Structure Structure
TM6 287 G 6.59x59 Structure Structure
TM6 288 L 6.60x60 Structure Structure
TM6 289 G 6.61x61 Structure Structure
ECL3 290 V - Structure Structure
ECL3 291 Q - Structure Structure
ECL3 292 P - Structure Structure
ECL3 293 S - Structure Structure
TM7 294 S 7.28x27 Structure Structure
TM7 295 E 7.29x28 Structure Structure
TM7 296 T 7.30x29 Structure Structure
TM7 297 A 7.31x30 Structure Structure
TM7 298 V 7.32x31 Structure Structure
TM7 299 A 7.33x32 Structure Structure
TM7 300 I 7.34x33 Structure Structure
TM7 301 L 7.35x34 Structure Structure
TM7 302 R 7.36x35 Structure Structure
TM7 303 F 7.37x36 Structure Structure
TM7 304 C 7.38x37 Structure Structure
TM7 305 T 7.39x38 Structure Structure
TM7 306 A 7.40x39 Structure Structure
TM7 307 L 7.41x40 Structure Structure
TM7 308 G 7.42x41 Structure Structure
TM7 309 Y 7.43x42 Structure Structure
TM7 310 V 7.44x43 Structure Structure
TM7 311 N 7.45x45 Structure Structure
TM7 312 S 7.46x46 Structure Structure
TM7 313 C 7.47x47 Structure Structure
TM7 314 L 7.48x48 Structure Structure
TM7 315 N 7.49x49 Structure Structure
TM7 316 P 7.50x50 Structure Structure
TM7 317 I 7.51x51 Structure Structure
TM7 318 L 7.52x52 Structure Structure
TM7 319 Y 7.53x53 Structure Structure
TM7 320 A 7.54x54 Structure Structure
TM7 321 F 7.55x55 Structure Structure
TM7 322 L 7.56x56 Structure Structure
H8 323 D 8.47x47 Structure Structure
H8 324 E 8.48x48 Structure Structure
H8 325 N 8.49x49 Structure Structure
H8 326 F 8.50x50 Structure Structure
H8 327 K 8.51x51 Structure Structure
H8 328 A 8.52x52 Structure Structure
H8 329 C 8.53x53 Structure Structure
H8 330 F 8.54x54 Structure Structure
H8 331 R 8.55x55 Structure Structure
H8 332 K 8.56x56 Structure Structure
H8 333 F 8.57x57 Structure Structure
H8 334 C 8.58x58 AF2 AF2
H8 335 C 8.59x59 AF2 AF2
C-term 336 A - AF2 AF2
C-term 337 S - AF2 AF2
C-term 338 A - AF2 AF2
C-term 339 L - AF2 AF2
C-term 340 R - AF2 AF2
C-term 341 R - AF2 AF2
C-term 342 D - AF2 AF2
C-term 343 V - AF2 AF2
C-term 344 Q - AF2 AF2
C-term 345 V - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 I 156 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 I 156 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM6 I 261 6x33 G.H5 F 354 G.H5.26
Van-der-waals H8 D 323 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL3 L 247 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 L 247 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 L 247 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 P 155 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 155 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 155 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL3 L 248 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 L 248 - G.H5 F 354 G.H5.26
Hydrophobic TM5 R 241 5x64 G.H5 I 344 G.H5.16
Polar ICL2 R 162 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 162 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 162 34x57 G.H5 C 351 G.H5.23
Hydrophobic TM6 N 257 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 N 257 6x29 G.H5 F 354 G.H5.26
Polar H8 N 325 8x49 G.H5 D 350 G.H5.22
Polar ICL2 R 162 34x57 G.H5 N 347 G.H5.19
Hydrophobic ICL3 R 246 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 246 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 V 245 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 155 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 155 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL3 L 247 - G.H5 K 345 G.H5.17
Hydrophobic TM5 L 242 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 L 247 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 L 247 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 I 152 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM5 M 238 5x61 G.H5 L 353 G.H5.25
Ionic TM6 K 254 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 254 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 254 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 L 159 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 152 3x54 G.H5 L 348 G.H5.20
Ionic ICL2 D 160 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 160 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 160 34x55 G.hns1 R 32 G.hns1.03
Polar TM3 A 151 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 151 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 V 265 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 261 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 261 6x33 G.H5 L 353 G.H5.25
Ionic ICL3 R 246 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 246 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 246 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 246 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 A 151 3x53 G.H5 C 351 G.H5.23