Refined structure (7D7M) of Gs - EP4 receptor

RECEPTOR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-19

3D VIEW

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Structure (7D7M)
Model (AlphaFold2-Multimer)

REFINED G PROTEIN RESIDUES

Residue backbones - 228 from structure (57.9%), 166 from model (42.1%)
Residue sidechains - 180 from structure (45.7%), 214 from model (54.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 AF2 AF2
G.HN 12 Q G.HN.29 Structure AF2
G.HN 13 R G.HN.30 Structure AF2
G.HN 14 N G.HN.31 Structure AF2
G.HN 15 E G.HN.32 Structure AF2
G.HN 16 E G.HN.33 Structure AF2
G.HN 17 K G.HN.34 Structure AF2
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure AF2
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure AF2
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure AF2
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure AF2
G.HN 31 Q G.HN.48 Structure AF2
G.HN 32 K G.HN.49 Structure AF2
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure AF2
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure AF2
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure AF2
G.s1h1 50 E G.s1h1.04 Structure AF2
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure Structure
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure AF2
G.H1 59 Q G.H1.07 Structure AF2
G.H1 60 M G.H1.08 AF2 AF2
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 Structure Structure
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure AF2
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure AF2
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure AF2
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure Structure
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure AF2
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure AF2
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure AF2
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 Structure Structure
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 AF2 AF2
G.s4h3 264 N G.s4h3.15 AF2 AF2
G.H3 265 R G.H3.01 Structure AF2
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure AF2
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure AF2
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure AF2
G.s5hg 293 K G.s5hg.01 Structure AF2
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure AF2
G.HG 300 K G.HG.07 Structure AF2
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure AF2
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure AF2
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure AF2
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure AF2
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure AF2
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure AF2
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure AF2
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure AF2
G.hgh4 331 D G.hgh4.21 Structure AF2
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure AF2
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure AF2
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure AF2
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure AF2
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure AF2
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure AF2
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure AF2
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure AF2
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 AF2 AF2

REFINED GPCR RESIDUES

Residue backbones - 282 from structure (85.2%), 49 from model (14.8%)
Residue sidechains - 250 from structure (75.5%), 81 from model (24.5%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 S - AF2 AF2
N-term 3 T - AF2 AF2
N-term 4 P - AF2 AF2
N-term 5 G - AF2 AF2
N-term 6 V - AF2 AF2
N-term 7 N - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 S - AF2 AF2
N-term 10 A - AF2 AF2
N-term 11 S - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 S - AF2 AF2
N-term 14 P - AF2 AF2
N-term 15 D - AF2 AF2
N-term 16 R - AF2 AF2
N-term 17 L - AF2 AF2
TM1 18 N 1.33x33 AF2 AF2
TM1 19 S 1.34x34 AF2 AF2
TM1 20 P 1.35x35 AF2 AF2
TM1 21 V 1.36x36 AF2 AF2
TM1 22 T 1.37x37 Structure Structure
TM1 23 I 1.38x38 Structure Structure
TM1 24 P 1.39x39 Structure Structure
TM1 25 A 1.40x40 Structure Structure
TM1 26 V 1.41x41 Structure Structure
TM1 27 M 1.42x42 Structure Structure
TM1 28 F 1.43x43 Structure Structure
TM1 29 I 1.44x44 Structure Structure
TM1 30 F 1.45x45 Structure Structure
TM1 31 G 1.46x46 Structure Structure
TM1 32 V 1.47x47 Structure Structure
TM1 33 V 1.48x48 Structure Structure
TM1 34 G 1.49x49 Structure Structure
TM1 35 N 1.50x50 Structure Structure
TM1 36 L 1.51x51 Structure Structure
TM1 37 V 1.52x52 Structure Structure
TM1 38 A 1.53x53 Structure Structure
TM1 39 I 1.54x54 Structure Structure
TM1 40 V 1.55x55 Structure Structure
TM1 41 V 1.56x56 Structure Structure
TM1 42 L 1.57x57 Structure Structure
TM1 43 C 1.58x58 Structure Structure
TM1 44 K 1.59x59 Structure AF2
TM1 45 S 1.60x60 Structure Structure
ICL1 46 R - Structure AF2
ICL1 47 K - Structure AF2
ICL1 48 E - Structure AF2
ICL1 49 Q - Structure AF2
ICL1 50 K - Structure Structure
ICL1 51 E - Structure Structure
TM2 52 T 2.37x37 Structure Structure
TM2 53 T 2.38x38 Structure Structure
TM2 54 F 2.39x39 Structure Structure
TM2 55 Y 2.40x40 Structure Structure
TM2 56 T 2.41x41 Structure Structure
TM2 57 L 2.42x42 Structure Structure
TM2 58 V 2.43x43 Structure Structure
TM2 59 C 2.44x44 Structure Structure
TM2 60 G 2.45x45 Structure Structure
TM2 61 L 2.46x46 Structure Structure
TM2 62 A 2.47x47 Structure Structure
TM2 63 V 2.48x48 Structure Structure
TM2 64 T 2.49x49 Structure Structure
TM2 65 D 2.50x50 Structure Structure
TM2 66 L 2.51x51 Structure Structure
TM2 67 L 2.52x52 Structure Structure
TM2 68 G 2.53x53 Structure Structure
TM2 69 T 2.54x54 Structure Structure
TM2 70 L 2.55x55 Structure Structure
TM2 71 L 2.56x551 Structure Structure
TM2 72 V 2.57x56 Structure Structure
TM2 73 S 2.58x57 Structure Structure
TM2 74 P 2.59x58 Structure Structure
TM2 75 V 2.60x59 Structure Structure
TM2 76 T 2.61x60 Structure Structure
TM2 77 I 2.62x61 Structure Structure
TM2 78 A 2.63x62 Structure Structure
TM2 79 T 2.64x63 Structure Structure
TM2 80 Y 2.65x64 Structure Structure
TM2 81 M 2.66x65 Structure AF2
TM2 82 K 2.67x66 Structure AF2
ECL1 83 G - Structure Structure
ECL1 84 Q 23.49x49 Structure AF2
ECL1 85 W 23.50x50 Structure Structure
ECL1 86 P 23.51x51 Structure Structure
ECL1 87 G 23.52x52 Structure Structure
TM3 88 G 3.21x21 Structure Structure
TM3 89 Q 3.22x22 Structure Structure
TM3 90 P 3.23x23 Structure Structure
TM3 91 L 3.24x24 Structure Structure
TM3 92 C 3.25x25 Structure Structure
TM3 93 E 3.26x26 Structure Structure
TM3 94 Y 3.27x27 Structure Structure
TM3 95 S 3.28x28 Structure Structure
TM3 96 T 3.29x29 Structure Structure
TM3 97 F 3.30x30 Structure Structure
TM3 98 I 3.31x31 Structure Structure
TM3 99 L 3.32x32 Structure Structure
TM3 100 L 3.33x33 Structure Structure
TM3 101 F 3.34x34 Structure Structure
TM3 102 F 3.35x35 Structure Structure
TM3 103 S 3.36x36 Structure Structure
TM3 104 L 3.37x37 Structure Structure
TM3 105 S 3.38x38 Structure Structure
TM3 106 G 3.39x39 Structure Structure
TM3 107 L 3.40x40 Structure Structure
TM3 108 S 3.41x41 Structure Structure
TM3 109 I 3.42x42 Structure Structure
TM3 110 I 3.43x43 Structure Structure
TM3 111 C 3.44x44 Structure Structure
TM3 112 A 3.45x45 Structure Structure
TM3 113 M 3.46x46 Structure Structure
TM3 114 S 3.47x47 Structure Structure
TM3 115 V 3.48x48 Structure Structure
TM3 116 E 3.49x49 Structure Structure
TM3 117 R 3.50x50 Structure Structure
TM3 118 Y 3.51x51 Structure Structure
TM3 119 L 3.52x52 Structure Structure
TM3 120 A 3.53x53 Structure Structure
TM3 121 I 3.54x54 Structure Structure
TM3 122 N 3.55x55 Structure Structure
TM3 123 H 3.56x56 Structure Structure
ICL2 124 A 34.50x50 Structure Structure
ICL2 125 Y 34.51x51 Structure Structure
ICL2 126 F 34.52x52 Structure Structure
ICL2 127 Y 34.53x53 Structure Structure
ICL2 128 S 34.54x54 Structure Structure
ICL2 129 H 34.55x55 Structure Structure
ICL2 130 Y 34.56x56 Structure Structure
ICL2 131 V 34.57x57 Structure Structure
TM4 132 D 4.38x38 Structure AF2
TM4 133 K 4.39x39 Structure Structure
TM4 134 R 4.40x40 Structure Structure
TM4 135 L 4.41x41 Structure Structure
TM4 136 A 4.42x42 Structure Structure
TM4 137 G 4.43x43 Structure Structure
TM4 138 L 4.44x44 Structure Structure
TM4 139 T 4.45x45 Structure Structure
TM4 140 L 4.46x46 Structure Structure
TM4 141 F 4.47x47 Structure Structure
TM4 142 A 4.48x48 Structure Structure
TM4 143 V 4.49x49 Structure Structure
TM4 144 Y 4.50x50 Structure Structure
TM4 145 A 4.51x51 Structure Structure
TM4 146 S 4.52x52 Structure Structure
TM4 147 N 4.53x53 Structure Structure
TM4 148 V 4.54x54 Structure Structure
TM4 149 L 4.55x55 Structure Structure
TM4 150 F 4.56x56 Structure Structure
TM4 151 C 4.57x57 Structure Structure
TM4 152 A 4.58x58 Structure Structure
TM4 153 L 4.59x59 Structure Structure
TM4 154 P 4.60x60 Structure Structure
TM4 155 N 4.61x61 Structure Structure
TM4 156 M 4.62x62 Structure AF2
TM4 157 G 4.63x63 Structure Structure
ECL2 158 L - Structure AF2
ECL2 159 G - Structure Structure
ECL2 160 S - Structure Structure
ECL2 161 S - Structure Structure
ECL2 162 R - Structure AF2
ECL2 163 L - Structure Structure
ECL2 164 Q - Structure AF2
ECL2 165 Y - Structure Structure
ECL2 166 P - Structure Structure
ECL2 167 D - Structure Structure
ECL2 168 T - Structure Structure
ECL2 169 W - Structure Structure
ECL2 170 C 45.50x50 Structure Structure
ECL2 171 F 45.51x51 Structure Structure
ECL2 172 I 45.52x52 Structure Structure
ECL2 173 D - Structure AF2
ECL2 174 W - Structure Structure
ECL2 175 T - Structure Structure
ECL2 176 T - Structure Structure
ECL2 177 N - Structure AF2
TM5 178 V 5.33x33 Structure Structure
TM5 179 T 5.34x34 Structure Structure
TM5 180 A 5.35x35 Structure Structure
TM5 181 H 5.36x36 Structure Structure
TM5 182 A 5.37x37 Structure Structure
TM5 183 A 5.38x38 Structure Structure
TM5 184 Y 5.39x39 Structure Structure
TM5 185 S 5.40x40 Structure Structure
TM5 186 Y 5.41x41 Structure Structure
TM5 187 M 5.42x42 Structure AF2
TM5 188 Y 5.43x43 Structure Structure
TM5 189 A 5.44x44 Structure Structure
TM5 190 G 5.45x45 Structure Structure
TM5 191 F 5.46x46 Structure Structure
TM5 192 S 5.47x47 Structure Structure
TM5 193 S 5.48x48 Structure Structure
TM5 194 F 5.49x49 Structure Structure
TM5 195 L 5.50x50 Structure Structure
TM5 196 I 5.51x51 Structure Structure
TM5 197 L 5.52x52 Structure Structure
TM5 198 A 5.53x53 Structure Structure
TM5 199 T 5.54x54 Structure Structure
TM5 200 V 5.55x55 Structure Structure
TM5 201 L 5.56x56 Structure Structure
TM5 202 C 5.57x57 Structure Structure
TM5 203 N 5.58x58 Structure Structure
TM5 204 V 5.59x59 Structure Structure
TM5 205 L 5.60x60 Structure Structure
TM5 206 V 5.61x61 Structure Structure
TM5 207 C 5.62x62 Structure Structure
TM5 208 G 5.63x63 Structure Structure
TM5 209 A 5.64x64 Structure Structure
TM5 210 L 5.65x65 Structure Structure
TM5 211 L 5.66x66 Structure Structure
TM5 212 R 5.67x67 Structure Structure
TM5 213 M 5.68x68 Structure Structure
TM5 214 H 5.69x69 Structure Structure
TM5 215 R 5.70x70 Structure Structure
TM5 216 Q 5.71x71 Structure Structure
TM5 217 F 5.72x72 Structure Structure
TM5 218 M 5.73x73 AF2 AF2
TM5 219 R 5.74x74 AF2 AF2
TM5 220 R 5.75x75 AF2 AF2
TM5 221 T 5.76x76 AF2 AF2
ICL3 222 S - AF2 AF2
ICL3 223 L - AF2 AF2
ICL3 224 G - AF2 AF2
ICL3 225 T - AF2 AF2
ICL3 226 E - AF2 AF2
ICL3 227 Q - AF2 AF2
ICL3 228 H - AF2 AF2
ICL3 254 F - AF2 AF2
ICL3 255 R - AF2 AF2
ICL3 256 R - AF2 AF2
ICL3 257 R - AF2 AF2
ICL3 258 R - AF2 AF2
ICL3 259 S - AF2 AF2
ICL3 260 F - Structure Structure
TM6 261 R 6.24x24 Structure Structure
TM6 262 R 6.25x25 Structure Structure
TM6 263 I 6.26x26 Structure Structure
TM6 264 A 6.27x27 Structure Structure
TM6 265 G 6.28x28 Structure Structure
TM6 266 A 6.29x29 Structure Structure
TM6 267 E 6.30x30 Structure Structure
TM6 268 I 6.31x31 Structure Structure
TM6 269 Q 6.32x32 Structure Structure
TM6 270 M 6.33x33 Structure Structure
TM6 271 V 6.34x34 Structure Structure
TM6 272 I 6.35x35 Structure Structure
TM6 273 L 6.36x36 Structure Structure
TM6 274 L 6.37x37 Structure Structure
TM6 275 I 6.38x38 Structure Structure
TM6 276 A 6.39x39 Structure Structure
TM6 277 T 6.40x40 Structure Structure
TM6 278 S 6.41x41 Structure Structure
TM6 279 L 6.42x42 Structure Structure
TM6 280 V 6.43x43 Structure Structure
TM6 281 V 6.44x44 Structure Structure
TM6 282 L 6.45x45 Structure Structure
TM6 283 I 6.46x46 Structure Structure
TM6 284 C 6.47x47 Structure Structure
TM6 285 S 6.48x48 Structure Structure
TM6 286 I 6.49x49 Structure Structure
TM6 287 P 6.50x50 Structure Structure
TM6 288 L 6.51x51 Structure Structure
TM6 289 V 6.52x52 Structure Structure
TM6 290 V 6.53x53 Structure Structure
TM6 291 R 6.54x54 Structure Structure
TM6 292 V 6.55x55 Structure Structure
TM6 293 F 6.56x56 Structure Structure
TM6 294 V 6.57x57 Structure Structure
TM6 295 N 6.58x58 Structure Structure
TM6 296 Q 6.59x59 Structure AF2
TM6 297 L 6.60x60 Structure Structure
TM6 298 Y 6.61x61 Structure Structure
ECL3 299 Q - Structure AF2
ECL3 300 P - Structure Structure
ECL3 301 S - Structure Structure
ECL3 302 L - Structure Structure
ECL3 303 E - Structure AF2
ECL3 304 R - Structure AF2
ECL3 305 E - Structure AF2
ECL3 306 V - Structure Structure
ECL3 307 S - Structure Structure
ECL3 308 K - Structure AF2
TM7 309 N 7.33x32 Structure Structure
TM7 310 P 7.34x33 Structure Structure
TM7 311 D 7.35x34 Structure Structure
TM7 312 L 7.36x35 Structure Structure
TM7 313 Q 7.37x36 Structure Structure
TM7 314 A 7.38x37 Structure Structure
TM7 315 I 7.39x38 Structure Structure
TM7 316 R 7.40x39 Structure Structure
TM7 317 I 7.41x40 Structure Structure
TM7 318 A 7.42x41 Structure Structure
TM7 319 S 7.43x42 Structure Structure
TM7 320 V 7.44x43 Structure Structure
TM7 321 N 7.45x45 Structure Structure
TM7 322 P 7.46x46 Structure Structure
TM7 323 I 7.47x47 Structure Structure
TM7 324 L 7.48x48 Structure Structure
TM7 325 D 7.49x49 Structure Structure
TM7 326 P 7.50x50 Structure Structure
TM7 327 W 7.51x51 Structure Structure
TM7 328 I 7.52x52 Structure Structure
TM7 329 Y 7.53x53 Structure Structure
TM7 330 I 7.54x54 Structure Structure
TM7 331 L 7.55x55 Structure Structure
TM7 332 L 7.56x56 Structure Structure
H8 333 R 8.47x47 Structure AF2
H8 334 K 8.48x48 Structure AF2
H8 335 T 8.49x49 Structure AF2
H8 336 V 8.50x50 Structure Structure
H8 337 L 8.51x51 Structure AF2
H8 338 S 8.52x52 Structure Structure
H8 339 K 8.53x53 Structure AF2
H8 340 A 8.54x54 Structure Structure
H8 341 I 8.55x55 Structure AF2
H8 342 E 8.56x56 Structure AF2
H8 343 K 8.57x57 Structure AF2
H8 344 I 8.58x58 Structure AF2
H8 345 K 8.59x59 Structure AF2
H8 346 C 8.60x60 AF2 AF2
C-term 347 L - AF2 AF2
C-term 348 F - AF2 AF2
C-term 349 C - AF2 AF2
C-term 350 R - AF2 AF2
C-term 351 I - AF2 AF2
C-term 352 G - AF2 AF2
C-term 353 G - AF2 AF2
C-term 354 S - AF2 AF2
C-term 355 R - AF2 AF2
C-term 356 R - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

NGL is a WebGL based 3D viewer powered by MMTF.

GPCR Amino Acid GPCRdb# Segment G protein Amino Acid CGN# Interaction Type
A124 34.50x50 ICL2 I383 G.H5.15 hydrophobic
A124 34.50x50 ICL2 I383 G.H5.15 van-der-waals
G224 - ICL3 E322 G.hgh4.12 polar
G224 - ICL3 E322 G.hgh4.12 hydrophobic
G224 - ICL3 E322 G.hgh4.12 van-der-waals
G224 - ICL3 T320 G.hgh4.10 hydrophobic
Y125 34.51x51 ICL2 H41 G.S1.02 aromatic
Y125 34.51x51 ICL2 H41 G.S1.02 hydrophobic
Y125 34.51x51 ICL2 H41 G.S1.02 van-der-waals
L223 - ICL3 R342 G.H4.12 hydrophobic
L223 - ICL3 R342 G.H4.12 van-der-waals
M270 6.33x33 TM6 Y391 G.H5.23 hydrophobic
D132 4.38x38 TM4 R38 G.hns1.02 ionic
D132 4.38x38 TM4 R38 G.hns1.02 polar
D132 4.38x38 TM4 R38 G.hns1.02 hydrophobic
D132 4.38x38 TM4 R38 G.hns1.02 van-der-waals
R220 5.75x75 TM5 D381 G.H5.13 ionic
H129 34.55x55 ICL2 A39 G.hns1.03 polar
H129 34.55x55 ICL2 A39 G.hns1.03 hydrophobic
T225 - ICL3 P321 G.hgh4.11 hydrophobic
T225 - ICL3 P321 G.hgh4.11 van-der-waals
K47 - ICL1 R389 G.H5.21 polar
K47 - ICL1 R389 G.H5.21 van-der-waals
A124 34.50x50 ICL2 Q384 G.H5.16 hydrophobic
R257 - ICL3 E322 G.hgh4.12 ionic
R257 - ICL3 E322 G.hgh4.12 polar
K334 8.48x48 H8 L394 G.H5.26 polar
K334 8.48x48 H8 L394 G.H5.26 hydrophobic
K334 8.48x48 H8 L394 G.H5.26 van-der-waals
L332 7.56x56 TM7 L393 G.H5.25 hydrophobic
L332 7.56x56 TM7 L393 G.H5.25 van-der-waals
R46 - ICL1 L393 G.H5.25 polar
V41 1.56x56 TM1 L393 G.H5.25 hydrophobic
V41 1.56x56 TM1 L393 G.H5.25 van-der-waals
Y127 34.53x53 ICL2 Q390 G.H5.22 polar
M213 5.68x68 TM5 Q384 G.H5.16 hydrophobic
M213 5.68x68 TM5 Q384 G.H5.16 van-der-waals
T335 8.49x49 H8 L394 G.H5.26 hydrophobic
T335 8.49x49 H8 L394 G.H5.26 van-der-waals
Y125 34.51x51 ICL2 F219 G.S3.03 hydrophobic
Y125 34.51x51 ICL2 F219 G.S3.03 van-der-waals
Y125 34.51x51 ICL2 V217 G.S3.01 hydrophobic
S338 8.52x52 H8 L394 G.H5.26 hydrophobic
S338 8.52x52 H8 L394 G.H5.26 van-der-waals
T225 - ICL3 T320 G.hgh4.10 polar
T225 - ICL3 T320 G.hgh4.10 hydrophobic
T225 - ICL3 T320 G.hgh4.10 van-der-waals
N122 3.55x55 TM3 R380 G.H5.12 polar
N122 3.55x55 TM3 R380 G.H5.12 van-der-waals
I121 3.54x54 TM3 L388 G.H5.20 hydrophobic
I121 3.54x54 TM3 L388 G.H5.20 van-der-waals
L223 - ICL3 L346 G.H4.16 hydrophobic
F217 5.72x72 TM5 R385 G.H5.17 hydrophobic
R46 - ICL1 L394 G.H5.26 hydrophobic
R46 - ICL1 L394 G.H5.26 van-der-waals
F54 2.39x39 TM2 Y391 G.H5.23 aromatic
F54 2.39x39 TM2 Y391 G.H5.23 hydrophobic
F54 2.39x39 TM2 Y391 G.H5.23 van-der-waals
E116 3.49x49 TM3 Y391 G.H5.23 polar
E116 3.49x49 TM3 Y391 G.H5.23 hydrophobic
E116 3.49x49 TM3 Y391 G.H5.23 van-der-waals
M213 5.68x68 TM5 R385 G.H5.17 hydrophobic
M213 5.68x68 TM5 R385 G.H5.17 van-der-waals
K50 - ICL1 Q390 G.H5.22 polar
L223 - ICL3 D323 G.hgh4.13 polar
L223 - ICL3 D323 G.hgh4.13 hydrophobic
L223 - ICL3 D323 G.hgh4.13 van-der-waals
K47 - ICL1 E392 G.H5.24 polar
K47 - ICL1 E392 G.H5.24 hydrophobic
K47 - ICL1 E392 G.H5.24 van-der-waals
G224 - ICL3 P321 G.hgh4.11 hydrophobic
G224 - ICL3 P321 G.hgh4.11 van-der-waals
I121 3.54x54 TM3 Q384 G.H5.16 polar
I121 3.54x54 TM3 Q384 G.H5.16 hydrophobic
I121 3.54x54 TM3 Q384 G.H5.16 van-der-waals
T52 2.37x37 TM2 Q390 G.H5.22 polar
T52 2.37x37 TM2 Q390 G.H5.22 hydrophobic
T52 2.37x37 TM2 Q390 G.H5.22 van-der-waals
K334 8.48x48 H8 E392 G.H5.24 ionic
K334 8.48x48 H8 E392 G.H5.24 polar
K334 8.48x48 H8 E392 G.H5.24 hydrophobic
K334 8.48x48 H8 E392 G.H5.24 van-der-waals
L223 - ICL3 E322 G.hgh4.12 polar
L223 - ICL3 E322 G.hgh4.12 hydrophobic
L223 - ICL3 E322 G.hgh4.12 van-der-waals
F217 5.72x72 TM5 Y358 G.h4s6.20 hydrophobic
Y125 34.51x51 ICL2 I383 G.H5.15 hydrophobic
A120 3.53x53 TM3 H387 G.H5.19 hydrophobic
A120 3.53x53 TM3 H387 G.H5.19 van-der-waals
T225 - ICL3 T319 G.hgh4.09 hydrophobic
T225 - ICL3 T319 G.hgh4.09 van-der-waals
L332 7.56x56 TM7 E392 G.H5.24 hydrophobic
T225 - ICL3 E322 G.hgh4.12 hydrophobic
T225 - ICL3 E322 G.hgh4.12 van-der-waals
R220 5.75x75 TM5 D378 G.H5.10 ionic
R220 5.75x75 TM5 D378 G.H5.10 polar
E267 6.30x30 TM6 L388 G.H5.20 hydrophobic
E267 6.30x30 TM6 L388 G.H5.20 van-der-waals
S128 34.54x54 ICL2 H41 G.S1.02 hydrophobic
I263 6.26x26 TM6 Y358 G.h4s6.20 polar
I263 6.26x26 TM6 Y358 G.h4s6.20 hydrophobic
I263 6.26x26 TM6 Y358 G.h4s6.20 van-der-waals
R117 3.50x50 TM3 Y391 G.H5.23 polar
R117 3.50x50 TM3 Y391 G.H5.23 aromatic
R117 3.50x50 TM3 Y391 G.H5.23 hydrophobic
R117 3.50x50 TM3 Y391 G.H5.23 van-der-waals
Y125 34.51x51 ICL2 F376 G.H5.08 polar
Y125 34.51x51 ICL2 F376 G.H5.08 aromatic
Y125 34.51x51 ICL2 F376 G.H5.08 hydrophobic
Y125 34.51x51 ICL2 F376 G.H5.08 van-der-waals
Y127 34.53x53 ICL2 H387 G.H5.19 aromatic
Y127 34.53x53 ICL2 H387 G.H5.19 hydrophobic
Y127 34.53x53 ICL2 H387 G.H5.19 van-der-waals
H129 34.55x55 ICL2 H41 G.S1.02 polar
H129 34.55x55 ICL2 H41 G.S1.02 hydrophobic
A124 34.50x50 ICL2 H387 G.H5.19 polar
A124 34.50x50 ICL2 H387 G.H5.19 hydrophobic
L223 - ICL3 P321 G.hgh4.11 hydrophobic
L223 - ICL3 P321 G.hgh4.11 van-der-waals
H129 34.55x55 ICL2 Q35 G.HN.52 polar
S222 - ICL3 D323 G.hgh4.13 polar
S222 - ICL3 D323 G.hgh4.13 hydrophobic
S222 - ICL3 D323 G.hgh4.13 van-der-waals
M270 6.33x33 TM6 L388 G.H5.20 hydrophobic
T335 8.49x49 H8 L393 G.H5.25 polar
T335 8.49x49 H8 L393 G.H5.25 van-der-waals
Y125 34.51x51 ICL2 R380 G.H5.12 polar
Y125 34.51x51 ICL2 R380 G.H5.12 hydrophobic
Y125 34.51x51 ICL2 R380 G.H5.12 van-der-waals
Y125 34.51x51 ICL2 C379 G.H5.11 polar
Y125 34.51x51 ICL2 C379 G.H5.11 hydrophobic
Y125 34.51x51 ICL2 C379 G.H5.11 van-der-waals
L223 - ICL3 D343 G.H4.13 hydrophobic
L223 - ICL3 D343 G.H4.13 van-der-waals