BILF1 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Epstein-Barr virus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7JHJ

RESOLUTION

3.2 Å

REFERENCE

10.1016/J.IMMUNI.2021.06.001

PUBLICATION DATE

July 7, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic ICL3 K 216 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 K 216 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 K 216 - G.S6 Y 320 G.S6.02
Aromatic H8 H 288 8x49 G.H5 F 354 G.H5.26
Hydrophobic H8 H 288 8x49 G.H5 F 354 G.H5.26
Van-der-waals H8 H 288 8x49 G.H5 F 354 G.H5.26
Hydrophobic H8 S 287 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 S 287 8x48 G.H5 F 354 G.H5.26
Van-der-waals ICL2 P 131 - G.hns1 A 31 G.hns1.02
Hydrophobic TM5 L 212 5x65 G.H5 L 348 G.H5.20
Polar TM2 H 66 2x37 G.H5 K 349 G.H5.21
Hydrophobic TM2 H 66 2x37 G.H5 K 349 G.H5.21
Van-der-waals TM2 H 66 2x37 G.H5 K 349 G.H5.21
Polar TM3 S 128 3x56 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 128 3x56 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 128 3x56 G.H5 N 347 G.H5.19
Ionic TM2 H 66 2x37 G.H5 D 350 G.H5.22
Polar TM2 H 66 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 H 66 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 H 66 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM3 L 126 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM3 K 122 3x50 G.H5 L 348 G.H5.20
Hydrophobic ICL3 F 217 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 F 217 - G.H5 K 345 G.H5.17
Polar TM3 K 122 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 K 122 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 131 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 129 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 R 129 - G.H5 I 343 G.H5.15
Hydrophobic TM2 H 66 2x37 G.H5 G 352 G.H5.24
Hydrophobic ICL2 R 133 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 133 - G.hns1 A 31 G.hns1.02
Polar TM7 S 285 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 S 285 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 227 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM2 M 68 2x39 G.H5 G 352 G.H5.24
Hydrophobic TM3 A 125 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 125 3x53 G.H5 C 351 G.H5.23
Hydrophobic H8 F 286 8x47 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 131 - G.H5 I 343 G.H5.15
Polar H8 F 286 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 F 286 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 F 286 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 131 - G.S3 L 194 G.S3.01
Hydrophobic TM6 L 223 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 223 6x33 G.H5 F 354 G.H5.26
Polar ICL3 F 217 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 F 217 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 F 217 - G.h4s6 E 318 G.h4s6.12
Van-der-waals TM7 S 285 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM6 L 223 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 K 122 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM7 S 285 7x56 G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 129 - G.H5 T 340 G.H5.12
Hydrophobic ICL3 F 217 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 K 132 - G.H5 N 347 G.H5.19
Polar ICL3 K 216 - G.S6 I 319 G.S6.01
Hydrophobic ICL3 F 217 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 F 217 - G.H5 I 344 G.H5.16
Polar TM3 E 121 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 E 121 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 E 121 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 A 125 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 126 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 126 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 N 226 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 N 226 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 T 130 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 T 130 - G.H5 I 343 G.H5.15
Polar TM6 R 222 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM3 A 125 3x53 G.H5 L 348 G.H5.20