CCK1 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7EZM

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41589-021-00841-3

PUBLICATION DATE

Aug. 25, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

73 interactions (Click to see)

LIGANDS

CCK-8 - Agonist pubchem gtoplig chembl_ligand drug_central drugbank

PHYSIOLOGICAL LIGANDS

CCK-8, desulfated cholecystokinin-8, CCK-39, CCK-58, CCK-33, CCK-4, gastrin-17



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 147 34x51 G.S3 V 199 G.S3.01
Hydrophobic TM3 R 139 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM2 T 76 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 T 76 2x39 G.H5 Y 356 G.H5.23
Polar ICL2 R 150 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 R 150 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 R 150 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 N 304 6x26 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 N 304 6x26 G.h4s6 I 323 G.h4s6.20
Hydrophobic ICL3 N 299 - G.h4s6 I 323 G.h4s6.20
Van-der-waals ICL3 N 299 - G.h4s6 I 323 G.h4s6.20
Hydrophobic ICL3 N 299 - G.H4 V 314 G.H4.16
Van-der-waals ICL3 N 299 - G.H4 V 314 G.H4.16
Hydrophobic ICL2 L 147 34x51 G.S3 F 201 G.S3.03
Polar TM3 A 142 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 142 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 142 3x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 L 147 34x51 G.S1 L 40 G.S1.02
Polar H8 R 376 8x49 G.H5 K 354 G.H5.21
Hydrophobic H8 R 376 8x49 G.H5 K 354 G.H5.21
Van-der-waals H8 R 376 8x49 G.H5 K 354 G.H5.21
Van-der-waals ICL3 N 294 - G.H5 A 342 G.H5.09
Hydrophobic TM5 E 235 5x64 G.H5 L 349 G.H5.16
Polar TM6 N 304 6x26 G.h4s6 D 321 G.h4s6.12
Van-der-waals TM6 N 304 6x26 G.h4s6 D 321 G.h4s6.12
Hydrophobic ICL3 S 298 - G.h4s6 I 323 G.h4s6.20
Van-der-waals ICL3 S 298 - G.h4s6 I 323 G.h4s6.20
Hydrophobic TM6 L 315 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM2 V 75 2x38 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 143 3x54 G.H5 L 358 G.H5.25
Hydrophobic TM3 I 143 3x54 G.H5 L 349 G.H5.16
Polar ICL2 V 151 34x55 G.hns1 R 37 G.hns1.02
Polar ICL3 N 294 - G.H5 R 338 G.H5.05
Hydrophobic ICL3 N 294 - G.H5 R 338 G.H5.05
Van-der-waals ICL3 N 294 - G.H5 R 338 G.H5.05
Polar TM2 T 76 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM6 R 310 6x32 G.H5 V 359 G.H5.26
Hydrophobic TM3 E 138 3x49 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 P 146 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 146 34x50 G.H5 I 348 G.H5.15
Hydrophobic TM2 T 76 2x39 G.H5 N 357 G.H5.24
Hydrophobic ICL2 P 146 34x50 G.H5 K 345 G.H5.12
Van-der-waals ICL2 P 146 34x50 G.H5 K 345 G.H5.12
Hydrophobic ICL2 R 150 34x54 G.S1 L 40 G.S1.02
Van-der-waals ICL2 R 150 34x54 G.S1 L 40 G.S1.02
Hydrophobic ICL2 L 147 34x51 G.H5 F 341 G.H5.08
Hydrophobic TM5 L 236 5x65 G.H5 L 349 G.H5.16
Hydrophobic TM6 V 311 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 V 311 6x33 G.H5 L 358 G.H5.25
Ionic H8 R 376 8x49 G.H5 E 355 G.H5.22
Polar H8 R 376 8x49 G.H5 E 355 G.H5.22
Hydrophobic H8 R 376 8x49 G.H5 E 355 G.H5.22
Van-der-waals H8 R 376 8x49 G.H5 E 355 G.H5.22
Polar TM3 R 139 3x50 G.H5 N 357 G.H5.24
Polar ICL2 V 151 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 V 151 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 V 151 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 L 147 34x51 G.H5 K 345 G.H5.12
Hydrophobic TM2 L 80 2x43 G.H5 N 357 G.H5.24
Van-der-waals TM2 L 80 2x43 G.H5 N 357 G.H5.24
Polar ICL2 Q 153 34x57 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 Q 153 34x57 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 Q 153 34x57 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 L 147 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 147 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM3 A 142 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 142 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 R 150 34x54 G.H5 I 348 G.H5.15
Polar H8 N 374 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 N 374 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 N 374 8x47 G.H5 N 357 G.H5.24
Polar TM2 T 74 2x37 G.H5 E 355 G.H5.22
Polar TM4 T 154 4x38 G.hns1 R 37 G.hns1.02
Van-der-waals TM4 T 154 4x38 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 I 143 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 353 G.H5.20
Hydrophobic ICL3 S 300 - G.h4s6 I 323 G.h4s6.20
Hydrophobic TM6 A 307 6x29 G.H5 V 359 G.H5.26
Hydrophobic TM6 V 311 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 V 311 6x33 G.H5 V 359 G.H5.26
Polar TM7 Y 370 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 Y 370 7x53 G.H5 N 357 G.H5.24
Polar TM3 R 139 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 Y 356 G.H5.23
Polar ICL2 P 146 34x50 G.H5 N 352 G.H5.19
Hydrophobic ICL3 I 296 - G.H5 A 342 G.H5.09
Van-der-waals ICL3 I 296 - G.H5 A 342 G.H5.09
Polar ICL3 N 299 - G.S6 I 324 G.S6.01
Hydrophobic ICL3 I 296 - G.S6 Y 325 G.S6.02
Hydrophobic ICL3 I 296 - G.H5 F 339 G.H5.06
Van-der-waals ICL3 I 296 - G.H5 F 339 G.H5.06
Hydrophobic TM3 I 143 3x54 G.H5 N 352 G.H5.19
Hydrophobic ICL3 S 298 - G.S6 Y 325 G.S6.02