Structure information

CCK1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7EZM

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

D

REFERENCE

PUBLICATION DATE

Aug. 25, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Cholecystokinin-8 P101 2.64x63 TM2 polar (hydrogen bond with backbone)
Cholecystokinin-8 M121 3.32x32 TM3 hydrophobic
Cholecystokinin-8 V125 3.36x36 TM3 hydrophobic
Cholecystokinin-8 Y176 4.60x61 TM4 polar (charge-assisted hydrogen bond)
Cholecystokinin-8 F185 ECL2 hydrophobic
Cholecystokinin-8 R197 45.51x51 ECL2 polar (charge-assisted hydrogen bond)
Cholecystokinin-8 R197 45.51x51 ECL2 polar (charge-charge)
Cholecystokinin-8 R197 45.51x51 ECL2 polar (charge-assisted hydrogen bond)
Cholecystokinin-8 H210 5.39x40 TM5 polar (charge-assisted hydrogen bond)
Cholecystokinin-8 H210 5.39x40 TM5 polar (charge-assisted hydrogen bond)
Cholecystokinin-8 N333 6.55x55 TM6 polar (hydrogen bond)
Cholecystokinin-8 N333 6.55x55 TM6 polar (hydrogen bond)
Cholecystokinin-8 R336 6.58x58 TM6 polar (charge-assisted hydrogen bond)
Cholecystokinin-8 R336 6.58x58 TM6 polar (charge-charge)
Cholecystokinin-8 E344 ECL3 polar (charge-assisted hydrogen bond)
Cholecystokinin-8 L347 ECL3 hydrophobic
Cholecystokinin-8 S348 ECL3 polar (hydrogen bond)
Cholecystokinin-8 I352 7.35x34 TM7 hydrophobic
Cholecystokinin-8 Y360 7.43x42 TM7 polar (hydrogen bond)

Ligands

Cholecystokinin-8

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Residue Diagrams

T N G L V S L L F I L S Y L L I Q V A P 1 L S L A V S D L M L C F L C M P F N L I P 2 A V L N F T S V S V S T G M F Y T T T K 3 A L K V I A A T W C L S F T I M T P Y 4 Y A V M M V I G P I L F L I L L L F T H W 5 I V I V V L F F L C W M P I F S A N A W 6 I P N V C S S T Y S L L L I F S I P T 7
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ICL1 K R M R ICL1ECL1 D F I F ECL1ICL2 P L Q S R V W Q ICL2ECL2 N L V P F T K N N N Q T A N M C R F L L P ECL2ICL3 Q K K S A K E R K P S T T S S G K Y E D S D G C Y L Q K T R P P R K L E L R Q L S T G S S S R A N R I R S N S ICL3ECL3 T A S A E R R L S ECL3N-term M D V V D S L L V N G S N I T P P C E L G L E N E T L F C L D Q P R P S K E N-termC-term P G P P G A R G E V G E E E E G G T T G A S L S R F S Y S H M S A S V P P Q C-term W Q P A V Q I L L Y S L I F L L S V L G N T L V I T V L I R N T V T N I F L L S L A V S D L M L C L F C M P F N L I P N L L K G S A V C K T T T Y F M G T S V S V S T F N L V A I S L E R Y G A I C K T K S H A L K V I A A T W C L S F T I M T P Y P I Y S N D V M Q Q S W H T F L L L I L F L I P G I V M M V A Y G L I S L E L Y Q G I K F E A S S A A N L M A K K R V I R M L I V I V V L F F L C W M P I F S A N A W R A Y D G T P I S F I L L L S Y T S S C V N P I I Y C F M N K R F M A C P N F R L G T F P C
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCK1 receptor
TM2
2x63 2.64x63 P101
TM3
3x32 3.32x32 M121
3x36 3.36x36 V125
TM4
4x61 4.60x61 Y176
ECL2
45x51 45.51x51 R197
TM5
5x40 5.39x40 H210
TM6
6x55 6.55x55 N333
6x58 6.58x58 R336
TM7
7x34 7.35x34 I352
7x42 7.43x42 Y360