TAS2R43 - Gi1

GPCR CLASS (FAMILY)

Class T2 (Taste 2)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

April 22, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

aristolochic acid - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Van-der-waals TM7 G 282 7x56 G.H5 G 352 G.H5.24
Polar H8 N 283 8x47 G.H5 F 354 G.H5.26
Hydrophobic H8 N 283 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 N 283 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 223 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 V 223 6x30 G.H5 K 345 G.H5.17
Hydrophobic TM6 K 226 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 226 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 110 3x54 G.H5 C 351 G.H5.23
Polar TM6 S 220 6x27 G.H5 D 341 G.H5.13
Van-der-waals TM6 S 220 6x27 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 110 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 T 230 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 230 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 Y 106 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 106 3x50 G.H5 C 351 G.H5.23
Polar H8 K 284 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 K 284 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 K 284 8x48 G.H5 F 354 G.H5.26
Polar H8 N 283 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 N 283 8x47 G.H5 G 352 G.H5.24
Polar TM6 H 224 6x31 G.H5 K 345 G.H5.17
Hydrophobic TM6 H 224 6x31 G.H5 K 345 G.H5.17
Van-der-waals TM6 H 224 6x31 G.H5 K 345 G.H5.17
Hydrophobic TM2 A 44 2x39 G.H5 C 351 G.H5.23
Ionic TM6 H 224 6x31 G.H5 D 341 G.H5.13
Polar TM6 H 224 6x31 G.H5 D 341 G.H5.13
Van-der-waals TM6 H 224 6x31 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 205 5x68 G.H5 T 340 G.H5.12
Ionic TM3 K 109 3x53 G.H5 D 350 G.H5.22
Polar TM3 K 109 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 K 109 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 K 109 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM5 M 209 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 M 209 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM6 H 224 6x31 G.H5 L 348 G.H5.20
Polar TM6 S 220 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 220 6x27 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 220 6x27 G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL2 R 123 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 M 209 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 M 209 5x72 G.H5 D 337 G.H5.09
Ionic ICL3 K 214 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 K 214 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 K 214 - G.h4s6 E 318 G.h4s6.12
Polar TM6 S 220 6x27 G.H5 K 345 G.H5.17
Hydrophobic TM6 S 220 6x27 G.H5 K 345 G.H5.17
Van-der-waals TM6 S 220 6x27 G.H5 K 345 G.H5.17
Polar TM3 K 109 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 109 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 109 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 H 205 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 205 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM3 Y 106 3x50 G.H5 L 353 G.H5.25
Ionic TM5 H 205 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 205 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 205 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 205 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM3 K 109 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 109 3x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 N 112 - G.H5 I 344 G.H5.16
Hydrophobic TM6 V 223 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM6 A 227 6x34 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 110 3x54 G.H5 L 353 G.H5.25
Polar TM7 G 282 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM7 G 282 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 G 282 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM7 G 282 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 G 282 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM6 H 224 6x31 G.H5 I 344 G.H5.16
Van-der-waals TM6 H 224 6x31 G.H5 I 344 G.H5.16
Hydrophobic TM6 A 227 6x34 G.H5 L 353 G.H5.25
Ionic TM5 K 208 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 K 208 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 K 208 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 L 202 5x65 G.H5 I 344 G.H5.16
Ionic TM5 H 212 5x75 G.H5 D 337 G.H5.09
Polar TM5 H 212 5x75 G.H5 D 337 G.H5.09
Hydrophobic TM5 H 212 5x75 G.H5 D 337 G.H5.09
Van-der-waals TM5 H 212 5x75 G.H5 D 337 G.H5.09
Hydrophobic TM3 I 110 3x54 G.H5 N 347 G.H5.19