κ receptor - Gz

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8DZS

RESOLUTION

2.7 Å

REFERENCE

10.1038/S41586-023-06030-7

PUBLICATION DATE

May 3, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

39 interactions (Click to see)

LIGANDS

CHEMBL277863 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

α-neoendorphin, big dynorphin, β-endorphin, dynorphin A, dynorphin A-(1-8), [Leu]enkephalin, dynorphin A-(1-13), β-neoendorphin, dynorphin B, [Met]enkephalin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL3 R 257 - G.h4s6 E 319 G.h4s6.12
Polar ICL3 R 257 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 R 257 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 R 257 - G.h4s6 E 319 G.h4s6.12
Polar C-term N 336 - G.H5 K 350 G.H5.21
Hydrophobic C-term N 336 - G.H5 K 350 G.H5.21
Van-der-waals C-term N 336 - G.H5 K 350 G.H5.21
Hydrophobic ICL2 L 167 - G.H5 I 344 G.H5.15
Van-der-waals ICL3 R 257 - G.H5 Q 346 G.H5.17
Hydrophobic ICL3 L 258 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 L 258 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 L 258 - G.h4s6 K 318 G.h4s6.11
Hydrophobic TM6 K 265 6x26 G.h4s6 E 316 G.h4s6.09
Polar C-term E 335 - G.H5 G 353 G.H5.24
Hydrophobic C-term E 335 - G.H5 G 353 G.H5.24
Van-der-waals C-term E 335 - G.H5 G 353 G.H5.24
Hydrophobic ICL2 V 164 - G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 V 164 - G.s2s3 E 194 G.s2s3.02
Hydrophobic TM6 I 272 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 272 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 163 - G.H5 I 345 G.H5.16
Hydrophobic ICL3 L 258 - G.h4s6 T 317 G.h4s6.10
Polar ICL2 L 167 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 L 167 - G.hns1 R 31 G.hns1.02
Hydrophobic TM3 A 159 3x53 G.H5 I 352 G.H5.23
Hydrophobic ICL3 R 257 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 R 257 - G.S6 Y 321 G.S6.02
Hydrophobic ICL2 P 163 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 163 - G.H5 I 344 G.H5.15
Hydrophobic TM3 V 160 3x54 G.H5 L 349 G.H5.20
Hydrophobic ICL2 V 164 - G.S3 L 195 G.S3.01
Ionic ICL2 D 168 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL3 L 258 - G.h4s6 E 316 G.h4s6.09
Van-der-waals ICL3 L 258 - G.h4s6 E 316 G.h4s6.09
Ionic ICL2 D 168 - G.hns1 R 32 G.hns1.03
Polar ICL2 D 168 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 168 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 168 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 R 252 5x64 G.H5 I 345 G.H5.16
Polar C-term N 336 - G.H5 Y 351 G.H5.22
Van-der-waals C-term N 336 - G.H5 Y 351 G.H5.22
Van-der-waals C-term D 334 - G.H5 I 352 G.H5.23
Hydrophobic ICL3 L 258 - G.H5 Q 346 G.H5.17
Van-der-waals ICL3 L 258 - G.H5 Q 346 G.H5.17
Hydrophobic ICL2 R 170 - G.H5 I 352 G.H5.23
Ionic TM5 R 252 5x64 G.H5 D 342 G.H5.13
Polar TM5 R 252 5x64 G.H5 D 342 G.H5.13
Ionic TM6 K 265 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 L 167 - G.S3 L 195 G.S3.01
Hydrophobic TM5 L 253 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM6 L 275 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM3 V 160 3x54 G.H5 I 345 G.H5.16
Hydrophobic ICL2 P 163 - G.H5 T 341 G.H5.12
Hydrophobic TM2 T 92 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM3 R 156 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 156 3x50 G.H5 I 352 G.H5.23
Polar TM2 T 94 2x39 G.H5 Y 351 G.H5.22
Hydrophobic ICL3 L 259 - G.H5 L 349 G.H5.20
Hydrophobic C-term N 336 - G.H5 G 353 G.H5.24
Van-der-waals C-term N 336 - G.H5 G 353 G.H5.24
Hydrophobic TM5 M 249 5x61 G.H5 L 354 G.H5.25
Hydrophobic C-term E 335 - G.H5 C 355 G.H5.26
Van-der-waals C-term E 335 - G.H5 C 355 G.H5.26
Polar TM3 A 159 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 159 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 159 3x53 G.H5 N 348 G.H5.19
Polar C-term D 334 - G.H5 G 353 G.H5.24
Hydrophobic C-term D 334 - G.H5 G 353 G.H5.24
Van-der-waals C-term D 334 - G.H5 G 353 G.H5.24
Ionic ICL3 R 257 - G.H5 D 342 G.H5.13
Polar ICL3 R 257 - G.H5 D 342 G.H5.13