NTS1 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Rattus norvegicus

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.6 Å

REFERENCE

PUBLICATION DATE

March 29, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

neurotensin - Agonist pubchem gtoplig chembl_ligand gtoplig gtoplig

ENDOGENOUS LIGANDS

neuromedin N, neurotensin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

GPCR AA GPCR number GPCRdb# Segment G protein AA G protein number CGN# Interaction Type
T 179 34x55 ICL2 R 32 G.HN.50 hydrophobic
I 171 3x54 TM3 L 245 G.s4h3.14 hydrophobic
K 178 34x54 ICL2 L 34 G.HN.52 hydrophobic
K 178 34x54 ICL2 L 34 G.HN.52 van-der-waals
E 166 3x49 TM3 Y 243 G.s4h3.12 hydrophobic
F 175 34x51 ICL2 F 228 G.S4.04 aromatic
F 175 34x51 ICL2 F 228 G.S4.04 hydrophobic
F 175 34x51 ICL2 F 228 G.S4.04 van-der-waals
S 373 - C-term N 244 G.s4h3.13 polar
S 373 - C-term N 244 G.s4h3.13 hydrophobic
S 373 - C-term N 244 G.s4h3.13 van-der-waals
A 170 3x53 TM3 Y 243 G.s4h3.12 hydrophobic
A 170 3x53 TM3 Y 243 G.s4h3.12 van-der-waals
I 171 3x54 TM3 N 239 G.s4h3.08 hydrophobic
A 170 3x53 TM3 N 239 G.s4h3.08 polar
A 170 3x53 TM3 N 239 G.s4h3.08 hydrophobic
A 170 3x53 TM3 N 239 G.s4h3.08 van-der-waals
R 167 3x50 TM3 L 245 G.s4h3.14 hydrophobic
R 167 3x50 TM3 L 245 G.s4h3.14 van-der-waals
F 175 34x51 ICL2 L 34 G.HN.52 hydrophobic
F 175 34x51 ICL2 L 34 G.HN.52 van-der-waals
L 303 6x30 TM6 V 246 G.s4h3.15 hydrophobic
L 303 6x30 TM6 V 246 G.s4h3.15 van-der-waals
I 171 3x54 TM3 L 240 G.s4h3.09 hydrophobic
G 306 6x33 TM6 L 245 G.s4h3.14 polar
G 306 6x33 TM6 L 245 G.s4h3.14 hydrophobic
G 306 6x33 TM6 L 245 G.s4h3.14 van-der-waals
F 175 34x51 ICL2 I 235 G.s4h3.04 hydrophobic
F 175 34x51 ICL2 I 235 G.s4h3.04 van-der-waals
L 264 5x65 TM5 L 240 G.s4h3.09 hydrophobic
V 102 2x39 TM2 E 242 G.s4h3.11 hydrophobic
V 102 2x39 TM2 E 242 G.s4h3.11 van-der-waals
F 175 34x51 ICL2 C 231 G.S4.07 hydrophobic
P 174 34x50 ICL2 I 235 G.s4h3.04 hydrophobic
P 174 34x50 ICL2 I 235 G.s4h3.04 van-der-waals
H 305 6x32 TM6 V 246 G.s4h3.15 hydrophobic
Y 369 7x53 TM7 N 244 G.s4h3.13 polar
Y 369 7x53 TM7 N 244 G.s4h3.13 van-der-waals
S 100 - ICL1 E 242 G.s4h3.11 polar
S 100 - ICL1 E 242 G.s4h3.11 van-der-waals
K 178 34x54 ICL2 R 31 G.HN.49 polar
S 373 - C-term L 245 G.s4h3.14 polar
V 102 2x39 TM2 Y 243 G.s4h3.12 hydrophobic
V 102 2x39 TM2 Y 243 G.s4h3.12 van-der-waals
G 306 6x33 TM6 V 246 G.s4h3.15 hydrophobic
L 310 6x37 TM6 L 245 G.s4h3.14 hydrophobic
F 175 34x51 ICL2 K 232 G.s4h3.01 hydrophobic
F 175 34x51 ICL2 K 232 G.s4h3.01 van-der-waals
F 175 34x51 ICL2 V 79 H.HA.11 hydrophobic
H 305 6x32 TM6 L 245 G.s4h3.14 polar
H 305 6x32 TM6 L 245 G.s4h3.14 hydrophobic
H 305 6x32 TM6 L 245 G.s4h3.14 van-der-waals
P 174 34x50 ICL2 K 232 G.s4h3.01 hydrophobic
K 178 34x54 ICL2 I 235 G.s4h3.04 hydrophobic
R 167 3x50 TM3 N 244 G.s4h3.13 polar
I 171 3x54 TM3 L 236 G.s4h3.05 hydrophobic
I 171 3x54 TM3 L 236 G.s4h3.05 van-der-waals
L 303 6x30 TM6 L 240 G.s4h3.09 hydrophobic
L 303 6x30 TM6 L 240 G.s4h3.09 van-der-waals
N 370 7x54 TM7 N 244 G.s4h3.13 polar
R 167 3x50 TM3 Y 243 G.s4h3.12 polar
R 167 3x50 TM3 Y 243 G.s4h3.12 hydrophobic
R 167 3x50 TM3 Y 243 G.s4h3.12 van-der-waals
L 106 2x43 TM2 N 244 G.s4h3.13 hydrophobic
L 106 2x43 TM2 N 244 G.s4h3.13 van-der-waals