Structure information

NTS1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8FMZ

SPECIES

Rattus norvegicus

RESOLUTION

2.590

PREFERRED CHAIN

A

REFERENCE

10.1021/ACS.BIOCHEM.3C00029

PUBLICATION DATE

March 29, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
neurotensin L55 N-term polar (hydrogen bond with backbone)
neurotensin L55 N-term Van der Waals
neurotensin D56 N-term polar (hydrogen bond with backbone)
neurotensin D56 N-term Van der Waals
neurotensin V57 N-term Van der Waals
neurotensin F128 2.65x64 TM2 hydrophobic
neurotensin F128 2.65x64 TM2 Van der Waals
neurotensin Y146 3.29x29 TM3 polar (hydrogen bond)
neurotensin Y146 3.29x29 TM3 Van der Waals
neurotensin M204 4.60x61 TM4 Van der Waals
neurotensin V224 ECL2 hydrophobic
neurotensin C225 45.50x50 ECL2 polar (hydrogen bond with backbone)
neurotensin C225 45.50x50 ECL2 Van der Waals
neurotensin T226 45.51x51 ECL2 Van der Waals
neurotensin R327 6.54x54 TM6 polar (charge-assisted hydrogen bond)
neurotensin R328 6.55x55 TM6 Van der Waals
neurotensin F331 6.58x58 TM6 Van der Waals
neurotensin F331 6.58x58 TM6 hydrophobic
neurotensin W339 ECL3 polar (hydrogen bond with backbone)
neurotensin W339 ECL3 Van der Waals
neurotensin F344 7.28x27 TM7 hydrophobic
neurotensin F344 7.28x27 TM7 Van der Waals
neurotensin Y347 7.31x30 TM7 polar (hydrogen bond)
neurotensin Y347 7.31x30 TM7 Van der Waals
neurotensin H348 7.32x31 TM7 Van der Waals
neurotensin Y351 7.35x34 TM7 Van der Waals

Ligands

neurotensin

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Residue Diagrams

S N G V T G V V F L A L Y I A T V L V K 1 G S L A L S D L L I L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A I P M 4 N L I S I V L M P F L F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I A S S V Y F L A N T L M Y F Y 7
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ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G L Q N R S G D G T H P G G L V C T P I V D ECL2ICL3 R V C T V G T H N G L E H S T F N M T I E ICL3ECL3 S D E Q W ECL3N-term M H L N S S V P Q G T P G E P D A Q P F S G P Q S E M E A T F L A L S L S N G S G N T S E S D T A G P N S D L D V N T D N-termC-term P G W R H R R K K R P T F S R K P N S M S S N H A F S T S A T R E T L Y C-term I Y S K V L V T A I Y L A L F V V G T V G N S V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L I L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A I P M L F T M T A T V K V V I Q V N T F M S F L F P M L V I S I L N T V I A N K L T V M V H Q A A E Q G P G R V Q A L R H G V L V L R A V V I A F V V C W L P Y H V R R L M F C Y I T T F L F D F Y H Y F Y M L T N A L F Y V S S A I N P I L Y N L V S A N F L S L C F R Q V T L A C
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Residue Table


GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM2
2x64 2.65x64 F128
TM3
3x29 3.29x29 Y146
TM4
4x61 4.60x61 M204
ECL2
45x50 45.50x50 C225
45x51 45.51x51 T226
TM6
6x54 6.54x54 R327
6x55 6.55x55 R328
6x58 6.58x58 F331
TM7
7x27 7.28x27 F344
7x30 7.31x30 Y347
7x31 7.32x31 H348
7x34 7.35x34 Y351