SST3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8ZBI

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

April 30, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

61 interactions (Click to see)

LIGANDS

SOMATOSTATIN - Agonist chembl_ligand pubchem drugbank drug_central pubchem

PHYSIOLOGICAL LIGANDS

cortistatin-14 (Mouse), SRIF-14 (Human), SRIF-28 (Human), CST-17 (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 R 254 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 254 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 254 6x32 G.H5 F 354 G.H5.26
Van-der-waals ICL3 W 241 - G.S6 I 319 G.S6.01
Polar TM6 R 254 6x32 G.H5 G 352 G.H5.24
Ionic TM6 R 250 6x28 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 250 6x28 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 250 6x28 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 250 6x28 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 250 6x28 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 250 6x28 G.H5 K 345 G.H5.17
Hydrophobic TM5 V 233 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 233 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 A 236 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 A 236 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL3 V 240 - G.H5 D 337 G.H5.09
Hydrophobic TM5 I 229 5x61 G.H5 L 353 G.H5.25
Polar TM6 R 254 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 254 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 254 6x32 G.H5 L 353 G.H5.25
Hydrophobic ICL3 V 240 - G.H5 D 341 G.H5.13
Hydrophobic TM3 V 145 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 145 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 T 149 - G.hns1 A 31 G.hns1.02
Polar ICL2 A 152 - G.HN E 28 G.HN.52
Polar TM6 R 250 6x28 G.S6 Y 320 G.S6.02
Polar H8 R 319 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 R 319 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 R 319 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL3 V 240 - G.S6 Y 320 G.S6.02
Polar TM2 T 79 2x39 G.H5 D 350 G.H5.22
Hydrophobic H8 Y 318 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM5 V 233 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 145 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM6 R 250 6x28 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 250 6x28 G.H5 F 354 G.H5.26
Hydrophobic ICL3 V 240 - G.H5 A 338 G.H5.10
Hydrophobic H8 Y 318 8x48 G.H5 K 349 G.H5.21
Ionic TM6 R 250 6x28 G.H5 D 341 G.H5.13
Polar TM6 R 250 6x28 G.H5 D 341 G.H5.13
Polar TM3 A 144 3x53 G.H5 N 347 G.H5.19
Polar TM3 R 141 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 M 258 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 144 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 R 239 5x71 G.H5 D 337 G.H5.09
Aromatic ICL3 W 241 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 W 241 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 W 241 - G.S6 Y 320 G.S6.02