PTH1 receptor - Gq

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

Oct. 16, 2024

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Parathyroid hormone - Agonist pubchem

PHYSIOLOGICAL LIGANDS

PTHrP-(1-36), PTHrP, PTH, TIP39



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 F 314 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 F 314 - G.S1 L 34 G.S1.02
Aromatic TM2 R 219 2x46 G.H5 Y 243 G.H5.23
Hydrophobic TM2 R 219 2x46 G.H5 Y 243 G.H5.23
Van-der-waals TM2 R 219 2x46 G.H5 Y 243 G.H5.23
Polar TM3 L 309 3x57 G.H5 N 239 G.H5.19
Hydrophobic TM3 L 309 3x57 G.H5 N 239 G.H5.19
Van-der-waals TM3 L 309 3x57 G.H5 N 239 G.H5.19
Polar H8 N 463 8x47 G.H5 E 242 G.H5.22
Van-der-waals H8 N 463 8x47 G.H5 E 242 G.H5.22
Hydrophobic TM5 I 381 5x57 G.H5 L 245 G.H5.25
Hydrophobic ICL2 F 314 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 F 314 - G.H5 F 228 G.H5.08
Polar TM6 S 409 6x41 G.H5 L 245 G.H5.25
Hydrophobic TM6 S 409 6x41 G.H5 L 245 G.H5.25
Van-der-waals TM6 S 409 6x41 G.H5 L 245 G.H5.25
Hydrophobic TM3 I 310 3x58 G.H5 L 240 G.H5.20
Van-der-waals TM3 I 310 3x58 G.H5 L 240 G.H5.20
Hydrophobic TM6 V 412 6x44 G.H5 L 245 G.H5.25
Ionic TM2 R 219 2x46 G.H5 E 242 G.H5.22
Polar TM2 R 219 2x46 G.H5 E 242 G.H5.22
Hydrophobic TM2 R 219 2x46 G.H5 E 242 G.H5.22
Van-der-waals TM2 R 219 2x46 G.H5 E 242 G.H5.22
Hydrophobic TM4 K 318 4x40 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 K 318 4x40 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 I 310 3x58 G.H5 L 245 G.H5.25
Hydrophobic ICL2 F 314 - G.S3 V 79 G.S3.01
Polar TM7 I 458 7x56 G.H5 N 244 G.H5.24
Hydrophobic TM7 Y 459 7x57 G.H5 Y 243 G.H5.23
Van-der-waals TM7 Y 459 7x57 G.H5 Y 243 G.H5.23
Polar TM7 C 462 7x60 G.H5 N 244 G.H5.24
Hydrophobic ICL2 A 313 - G.H5 K 232 G.H5.12
Van-der-waals ICL2 A 313 - G.H5 K 232 G.H5.12
Hydrophobic ICL2 F 314 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 F 314 - G.H5 I 235 G.H5.15
Hydrophobic TM5 L 385 5x61 G.H5 L 245 G.H5.25
Van-der-waals TM3 Y 305 3x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 F 314 - G.H5 C 231 G.H5.11
Hydrophobic TM3 L 306 3x54 G.H5 L 245 G.H5.25
Hydrophobic TM3 L 306 3x54 G.H5 Y 243 G.H5.23
Hydrophobic TM5 L 385 5x61 G.H5 L 240 G.H5.20
Hydrophobic ICL2 F 314 - G.H5 K 232 G.H5.12
Van-der-waals ICL2 F 314 - G.H5 K 232 G.H5.12
Hydrophobic TM6 L 413 6x45 G.H5 L 245 G.H5.25
Hydrophobic TM3 L 309 3x57 G.H5 Y 243 G.H5.23
Van-der-waals TM3 L 309 3x57 G.H5 Y 243 G.H5.23