NTS1 receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

June 3, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

JMV449 - Agonist pubchem gtoplig

PHYSIOLOGICAL LIGANDS

large neuromedin N (Mouse), neurotensin (Human), neuromedin N (Human), large neuromedin N (Human), large neuromedin N (Rat), large neurotensin (Human), neuromedin N (Mouse)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic ICL2 F 174 34x51 G.hns1 A 31 G.hns1.02
Hydrophobic TM2 V 101 2x39 G.H5 G 352 G.H5.24
Hydrophobic TM6 R 294 6x26 G.H5 I 344 G.H5.16
Van-der-waals TM6 R 294 6x26 G.H5 I 344 G.H5.16
Hydrophobic TM6 R 294 6x26 G.H5 D 341 G.H5.13
Hydrophobic ICL2 F 174 34x51 G.HN I 28 G.HN.52
Hydrophobic TM5 M 266 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 M 266 5x68 G.H5 I 344 G.H5.16
Polar TM3 R 166 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 166 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 166 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 R 294 6x26 G.H5 T 340 G.H5.12
Van-der-waals TM6 R 294 6x26 G.H5 T 340 G.H5.12
Hydrophobic TM6 G 301 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM2 V 101 2x39 G.H5 G 350 G.H5.22
Polar ICL1 Q 98 - G.H5 G 350 G.H5.22
Hydrophobic TM3 A 169 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 169 3x53 G.H5 C 351 G.H5.23
Polar ICL1 Q 98 - G.H5 R 349 G.H5.21
Hydrophobic ICL1 Q 98 - G.H5 R 349 G.H5.21
Van-der-waals ICL1 Q 98 - G.H5 R 349 G.H5.21
Hydrophobic TM6 A 297 6x29 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 297 6x29 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 305 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 305 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 166 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 170 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 304 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM2 V 101 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 298 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM6 A 297 6x29 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 F 174 34x51 G.HN K 24 G.HN.48
Hydrophobic TM6 A 297 6x29 G.H5 I 344 G.H5.16
Van-der-waals TM3 E 165 3x49 G.H5 G 350 G.H5.22
Hydrophobic ICL2 F 174 34x51 G.HN G 27 G.HN.51
Van-der-waals ICL2 F 174 34x51 G.HN G 27 G.HN.51