GPCR CLASS (FAMILY)
GPCR SPECIES
GPCR PREFERRED CHAIN
G PROTEIN (FAMILY)
G PROTEIN SPECIES
PDB CODE
RESOLUTION
REFERENCE
PUBLICATION DATE
LIGAND INTERACTIONS
LIGANDS
rotigotine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central
PHYSIOLOGICAL LIGANDS
L-NOREPINEPHRINE, noradrenaline, (-)-noradrenaline, 5-hydroxytryptamine, dopamine
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | A | 265 | 5x78 | G.H4 | L | 336 | G.H4.16 |
Hydrophobic | TM5 | A | 269 | 5x82 | G.H4 | D | 333 | G.H4.13 |
Van-der-waals | TM5 | A | 269 | 5x82 | G.H4 | D | 333 | G.H4.13 |
Aromatic | TM3 | R | 138 | 3x50 | G.H5 | Y | 381 | G.H5.23 |
Hydrophobic | TM3 | R | 138 | 3x50 | G.H5 | Y | 381 | G.H5.23 |
Van-der-waals | TM3 | R | 138 | 3x50 | G.H5 | Y | 381 | G.H5.23 |
Van-der-waals | TM6 | T | 297 | 6x36 | G.H5 | Y | 381 | G.H5.23 |
Hydrophobic | TM5 | A | 266 | 5x79 | G.H4 | L | 336 | G.H4.16 |
Van-der-waals | TM5 | A | 266 | 5x79 | G.H4 | L | 336 | G.H4.16 |
Polar | ICL2 | K | 149 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | K | 149 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | R | 150 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | ICL2 | K | 149 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | K | 149 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | TM6 | V | 294 | 6x33 | G.H5 | L | 383 | G.H5.25 |
Van-der-waals | TM6 | V | 294 | 6x33 | G.H5 | L | 383 | G.H5.25 |
Hydrophobic | TM6 | T | 297 | 6x36 | G.H5 | L | 383 | G.H5.25 |
Van-der-waals | TM6 | T | 297 | 6x36 | G.H5 | L | 383 | G.H5.25 |
Hydrophobic | TM5 | I | 248 | 5x61 | G.H5 | L | 383 | G.H5.25 |
Van-der-waals | TM5 | I | 248 | 5x61 | G.H5 | L | 383 | G.H5.25 |
Polar | TM5 | Q | 255 | 5x68 | G.H5 | R | 375 | G.H5.17 |
Hydrophobic | TM5 | Q | 255 | 5x68 | G.H5 | R | 375 | G.H5.17 |
Van-der-waals | TM5 | Q | 255 | 5x68 | G.H5 | R | 375 | G.H5.17 |
Hydrophobic | TM6 | K | 293 | 6x32 | G.H5 | E | 382 | G.H5.24 |
Van-der-waals | TM6 | K | 293 | 6x32 | G.H5 | E | 382 | G.H5.24 |
Hydrophobic | TM5 | I | 251 | 5x64 | G.H5 | Q | 374 | G.H5.16 |
Hydrophobic | TM4 | T | 153 | 4x38 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | TM4 | T | 153 | 4x38 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | F | 146 | 34x51 | G.H5 | R | 370 | G.H5.12 |
Van-der-waals | ICL2 | F | 146 | 34x51 | G.H5 | R | 370 | G.H5.12 |
Polar | TM5 | Q | 255 | 5x68 | G.H5 | D | 371 | G.H5.13 |
Hydrophobic | TM5 | Q | 255 | 5x68 | G.H5 | D | 371 | G.H5.13 |
Van-der-waals | TM5 | Q | 255 | 5x68 | G.H5 | D | 371 | G.H5.13 |
Hydrophobic | ICL2 | F | 146 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | F | 146 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Ionic | TM5 | R | 258 | 5x71 | G.H5 | D | 371 | G.H5.13 |
Polar | TM5 | R | 258 | 5x71 | G.H5 | D | 371 | G.H5.13 |
Van-der-waals | TM5 | R | 258 | 5x71 | G.H5 | D | 371 | G.H5.13 |
Ionic | TM5 | R | 264 | 5x77 | G.hgh4 | D | 313 | G.hgh4.13 |
Polar | TM5 | R | 264 | 5x77 | G.hgh4 | D | 313 | G.hgh4.13 |
Hydrophobic | TM5 | R | 264 | 5x77 | G.hgh4 | D | 313 | G.hgh4.13 |
Van-der-waals | TM5 | R | 264 | 5x77 | G.hgh4 | D | 313 | G.hgh4.13 |
Hydrophobic | TM5 | L | 262 | 5x75 | G.H4 | L | 336 | G.H4.16 |
Van-der-waals | TM5 | L | 262 | 5x75 | G.H4 | L | 336 | G.H4.16 |
Hydrophobic | ICL2 | P | 145 | 34x50 | G.H5 | R | 370 | G.H5.12 |
Van-der-waals | ICL2 | P | 145 | 34x50 | G.H5 | R | 370 | G.H5.12 |
Hydrophobic | TM6 | K | 290 | 6x29 | G.H5 | L | 384 | G.H5.26 |
Van-der-waals | TM6 | K | 290 | 6x29 | G.H5 | L | 384 | G.H5.26 |
Polar | TM5 | Q | 270 | 5x83 | G.H4 | R | 337 | G.H4.17 |
Hydrophobic | TM5 | Q | 270 | 5x83 | G.H4 | R | 337 | G.H4.17 |
Van-der-waals | TM5 | Q | 270 | 5x83 | G.H4 | R | 337 | G.H4.17 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | H | 377 | G.H5.19 |
Polar | TM5 | Q | 255 | 5x68 | G.H5 | Q | 374 | G.H5.16 |
Van-der-waals | TM5 | Q | 255 | 5x68 | G.H5 | Q | 374 | G.H5.16 |
Hydrophobic | TM5 | A | 269 | 5x82 | G.hgh4 | Y | 308 | G.hgh4.08 |
Van-der-waals | TM5 | A | 269 | 5x82 | G.hgh4 | Y | 308 | G.hgh4.08 |
Polar | TM3 | I | 142 | 3x54 | G.H5 | Q | 374 | G.H5.16 |
Van-der-waals | TM3 | I | 142 | 3x54 | G.H5 | Q | 374 | G.H5.16 |
Hydrophobic | ICL2 | F | 146 | 34x51 | G.H5 | C | 369 | G.H5.11 |
Van-der-waals | ICL2 | F | 146 | 34x51 | G.H5 | C | 369 | G.H5.11 |
Polar | TM5 | H | 268 | 5x81 | G.hgh4 | T | 309 | G.hgh4.09 |
Hydrophobic | TM5 | H | 268 | 5x81 | G.hgh4 | T | 309 | G.hgh4.09 |
Van-der-waals | TM5 | H | 268 | 5x81 | G.hgh4 | T | 309 | G.hgh4.09 |
Aromatic | ICL2 | F | 146 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | F | 146 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | F | 146 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | TM5 | I | 259 | 5x72 | G.H5 | L | 384 | G.H5.26 |
Hydrophobic | ICL2 | Y | 148 | 34x53 | G.H5 | H | 377 | G.H5.19 |
Van-der-waals | TM5 | L | 262 | 5x75 | G.S6 | C | 349 | G.S6.01 |
Hydrophobic | TM5 | A | 252 | 5x65 | G.H5 | L | 378 | G.H5.20 |
Van-der-waals | TM5 | A | 252 | 5x65 | G.H5 | L | 378 | G.H5.20 |
Hydrophobic | TM5 | E | 263 | 5x76 | G.h4s6 | T | 340 | G.h4s6.03 |
Van-der-waals | TM5 | E | 263 | 5x76 | G.h4s6 | T | 340 | G.h4s6.03 |
Hydrophobic | ICL2 | F | 146 | 34x51 | G.H5 | I | 373 | G.H5.15 |
Van-der-waals | ICL2 | F | 146 | 34x51 | G.H5 | I | 373 | G.H5.15 |
Hydrophobic | ICL2 | K | 149 | 34x54 | G.H5 | I | 373 | G.H5.15 |
Van-der-waals | ICL2 | K | 149 | 34x54 | G.H5 | I | 373 | G.H5.15 |
Hydrophobic | ICL2 | F | 146 | 34x51 | G.S3 | F | 219 | G.S3.03 |
Polar | TM6 | T | 297 | 6x36 | G.H5 | E | 382 | G.H5.24 |
Van-der-waals | TM6 | T | 297 | 6x36 | G.H5 | E | 382 | G.H5.24 |
Hydrophobic | TM5 | L | 262 | 5x75 | G.S6 | P | 351 | G.S6.03 |
Polar | TM3 | S | 143 | 3x55 | G.H5 | R | 370 | G.H5.12 |
Van-der-waals | TM3 | S | 143 | 3x55 | G.H5 | R | 370 | G.H5.12 |
Polar | TM3 | A | 141 | 3x53 | G.H5 | H | 377 | G.H5.19 |
Hydrophobic | TM3 | A | 141 | 3x53 | G.H5 | H | 377 | G.H5.19 |
Van-der-waals | TM3 | A | 141 | 3x53 | G.H5 | H | 377 | G.H5.19 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | L | 378 | G.H5.20 |
Van-der-waals | TM3 | I | 142 | 3x54 | G.H5 | L | 378 | G.H5.20 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | Y | 381 | G.H5.23 |
Van-der-waals | TM3 | I | 142 | 3x54 | G.H5 | Y | 381 | G.H5.23 |
Polar | H8 | N | 362 | 8x47 | G.H5 | Q | 380 | G.H5.22 |
Polar | TM6 | K | 293 | 6x32 | G.H5 | L | 384 | G.H5.26 |
Hydrophobic | TM6 | K | 293 | 6x32 | G.H5 | L | 384 | G.H5.26 |
Van-der-waals | TM6 | K | 293 | 6x32 | G.H5 | L | 384 | G.H5.26 |
Hydrophobic | ICL2 | P | 145 | 34x50 | G.H5 | I | 373 | G.H5.15 |
Van-der-waals | ICL2 | P | 145 | 34x50 | G.H5 | I | 373 | G.H5.15 |
Hydrophobic | TM5 | I | 256 | 5x69 | G.H5 | L | 384 | G.H5.26 |
Van-der-waals | TM5 | I | 256 | 5x69 | G.H5 | L | 384 | G.H5.26 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | L | 383 | G.H5.25 |
Polar | ICL2 | R | 150 | 34x55 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | R | 150 | 34x55 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | TM2 | T | 76 | 2x39 | G.H5 | Y | 381 | G.H5.23 |
Hydrophobic | TM5 | I | 259 | 5x72 | G.h4s6 | Y | 348 | G.h4s6.20 |
Van-der-waals | TM5 | I | 259 | 5x72 | G.h4s6 | Y | 348 | G.h4s6.20 |
Hydrophobic | TM5 | Q | 255 | 5x68 | G.H5 | L | 378 | G.H5.20 |
Van-der-waals | TM5 | A | 265 | 5x78 | G.H4 | R | 332 | G.H4.12 |
Hydrophobic | ICL2 | P | 145 | 34x50 | G.H5 | Q | 374 | G.H5.16 |
Van-der-waals | ICL2 | P | 145 | 34x50 | G.H5 | Q | 374 | G.H5.16 |
Hydrophobic | TM5 | I | 259 | 5x72 | G.H5 | R | 375 | G.H5.17 |
Van-der-waals | TM5 | I | 259 | 5x72 | G.H5 | R | 375 | G.H5.17 |
Hydrophobic | TM5 | A | 266 | 5x79 | G.h4s6 | T | 340 | G.h4s6.03 |
Van-der-waals | TM5 | A | 266 | 5x79 | G.h4s6 | T | 340 | G.h4s6.03 |
Hydrophobic | TM6 | L | 298 | 6x37 | G.H5 | L | 383 | G.H5.25 |
Van-der-waals | TM6 | L | 298 | 6x37 | G.H5 | L | 383 | G.H5.25 |
Van-der-waals | TM5 | R | 258 | 5x71 | G.H5 | R | 375 | G.H5.17 |
Aromatic | ICL2 | F | 146 | 34x51 | G.H5 | F | 366 | G.H5.08 |
Hydrophobic | ICL2 | F | 146 | 34x51 | G.H5 | F | 366 | G.H5.08 |
Van-der-waals | ICL2 | F | 146 | 34x51 | G.H5 | F | 366 | G.H5.08 |