ADGRL3 - Gi1

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Oct. 26, 2022

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
E52G.HNR03G.hns1GproteinE-S-GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.HNG.hns1GPCR segments:ICL2

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x393x503x533x545x615x625x645x655x686x40G.H5.25G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.S3.01G.hns1.03G.HN.52Res. Pos.ADGRL3 (7WYB)- (7WYB)-----------RLMLALKMHLRLMLALKMHLVDCNLLIIKELR

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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